Traditional drainage methods for marine reclamation typically consume large amounts of energy and have a negative environmental impact. The siphon-vacuum drainage method (SVD) automatically forms a vacuum and drains using less energy. It has significant potential for research and application. In this study, a theoretical model is used to calculate the vacuum formation process and drainage rate. Qualitative analysis and global sensitivity analysis were conducted to investigate the effect of various factors in the SVD on vacuum formation and drainage. The qualitative analysis suggests that modifying the length and diameter of the siphon pipe and the thickness of the sealing soil column to increase the siphon rate can improve the vacuum degree and drainage efficiency. Sobol global sensitivity analysis reveals that the sealing soil column thickness is the main factor affecting the vacuum, with a first-order sensitivity index accounting for up to 79.48%. The impact of cylinder diameter and the local resistance coefficient (0.43%) can be almost neglected. A fitting equation for estimating the maximum achievable vacuum is provided. Calculations show that the vacuum formed by the SVD can reach over 80 kPa. This work can help optimize SVD design and advance environmentally friendly marine reclamation projects.