This article addresses the problem of joint optimisation of production, setup and maintenance activities of unreliable manufacturing system producing two products. Given the complexity of the problem in a dynamic and stochastic environment, the literature has treated the problem separately by considering each axis individually (setup, production and maintenance) or by combining two axes simultaneously (production-setup, production-maintenance). Following the trend of scientific research advances that supports the fact that an integrated control leads to best performances, the main objective of this paper is to provide a control policy that will simultaneously combine the production, the setup and the preventive maintenance activities. To tackle the problem, an experimental resolution approach using combined continuous/discrete event simulation models is considered. The aim is to accurately imitate the production system behaviour, and to optimise the control policy parameters which minimise the total cost incurred. An in-depth study of the effects of the system parameter variation on the performance of the studied policies is performed in order to draw meaningful conclusions and to illustrate the robustness of the proposed resolution approach.