Mechanical ventilation (MV) can provide effective breathing support; however, ventilatior-induced lung injury (VILI) has also been widely recognized in clinical practice, including in the healthy lung. Unfortunately, the morbidity and mortality of VILI remain unacceptably high, and no satisfactory therapeutic effect can be achieved. The current study aimed to examine the effects of iron chelator preconditioning on the mitochondrial reactive oxygen species (ROS) in alveolar macrophages and pathological lung injury in VILI. Twenty four healthy male Sprague–Dawley (SD) rats (250–300 g in weight) were randomly divided into 3 groups, including the control group (NC group, n = 8), the high-volume mechanical ventilation group (HV group, n = 8), and the deferoxamine treatment group (HV + DFO group, n = 8). Rats in the HV and HV + DFO groups were subjected to high-volume MV at a dose of 40 ml/kg. DFO was administered at a dose of 200 mg/kg 15 min prior to over-ventilation. Spontaneously breathing anesthetized rats were used as the controls. The animals were sacrificed after 4 h of high-volume ventilation or under control conditions, the animals were sacrificed. Purified alveolar macrophages from bronchoalveolar lavage fluid (BALF) and lung tissue were collected for further analysis through light microscopy and flow cytometry. Compared with the controls, the high-volume-ventilated rats had exhibited typical lung edema and histological lung injury, and ROS were markedly increased in alveolar macrophages and mitochondria. Moreover, all indices of VILI were remarkably different in rats treated with DFO preconditioning. DFO could ameliorate lung injury in the mechanically ventilated SD rat model. DFO preconditioning contributes to mitigating the histological lung damage while reducing ROS levels in alveolar macrophages and mitochondria, suggesting that iron metabolism in alveolar macrophages may participate in VILI.

The Qiantang Sag, as one of the East China Sea Shelf Basin’s sags with thick residual Mesozoic strata, has long lacked comprehensive foundational sedimentary research, significantly impeding the understanding of the region’s resource potential and geological history. This study focuses on the Cretaceous strata of the Qiantang Sag, proposing a multi-phase sedimentary model for the Cretaceous Period. Through detailed analysis of the regional geological structure and sedimentary strata, this study unveils the complex sedimentary processes experienced by the Qiantang Sag during the Cretaceous. Utilizing drilling and core data combined with seismic geological interpretation, this study identifies that the western part of the Qiantang Sag predominantly developed alluvial fan and braided river deposits in an arid to semi-arid environment during the Cretaceous. Detrital zircon U-Pb dating analysis provides key information on the provenance areas and sedimentation ages, indicating that the Zhe-Min Uplift was the primary source region for the Qiantang Sag during the Cretaceous. Integrating vertical sedimentary sequences with provenance analysis, this study proposes sedimentary models and reconstructs the paleo-depositional evolution of the Qiantang Sag across different geological periods. During the Early Cretaceous Yushan Period, the region was influenced by intense volcanic activity, while also developing alluvial fan deposits in an arid environment. The Late Cretaceous Minjiang Period was characterized by semi-arid alluvial fan and braided river deposits. In contrast, the subsequent Shimentan Period saw the development of similar deposits, with the possible addition of seasonal lake deposits.

The Cenozoic sediments in marginal basins of East Asia ultimately reflected coupling between the tectonics, landscape evolution, and drainage reorganization. Recently, the provenance of Miocene sediments in the East China Sea Basin (ECSB) and Taiwan has been in hot debate, and several models were proposed to interpret the provenance changes. Most of them are related to river reorganization in East Asia and highly relied on detrital zircon U-Pb dating. In this study, a large number of detrital zircon U-Pb ages of Miocene sediments from the ECSB, Taiwan region, and the potential source areas have been compiled for quantitative provenance analysis. The results suggested that all the early–middle Miocene sediments in Taiwan and the ECSB were closely linked to North China and the Korean Peninsula. Over 80% sediments in Taiwan were delivered from the ECSB whose sediments were predominantly contributed by North China and the Korean Peninsula (70%). However, for the late Miocene to Quaternary sediments in the ECSB, the contribution of the Yangtze River system was 72%, which indicates distinct reorganization of river networks and initial formation of the Yangtze River in the late Miocene. The quantitative provenance analysis together with southward environmental changes from dominantly fluvial sediments in the northern and middle ECSB to shallow marine sediments in Taiwan region suggested that the early–middle Miocene sediments of Taiwan were mainly sourced from the North China and the Korean Peninsula by passing the ECSB. Thus, these sediments in Taiwan region would experience the river–delta–shallow marine route from the ECSB to Taiwan region.

The West Java Basin is a typical back-arc basin in Southeast Asia and one of Indonesia's main petroleum provinces. In the past ten years, it has been found that the new hydrocarbon reserves are on the rise, and a amount of resources to be discovered is significant. The distribution of hydrocarbon resources and the tectonic evolution characteristics of the basin are systematically explored, and the differences in hydrocarbon distribution and its main controlling factors in the back-arc basin of West Java are analyzed. The uneven distribution pattern of hydrocarbon is mainly controlled by the differential distribution of source rocks in the subsidence period. The distribution of the main source rocks is influenced by the "three-stage" tectonic development process that governs the distribution of sedimentary facies in various sedimentary environments throughout the tectonic subsidence period. Second, the weakening of the crust and magmatism facilitates the production of high heat flow values in the shallow strata of the back-arc area, thereby accelerating the pyrolysis and hydrocarbon generation of source rocks. The study delineates the formation and distribution of various types of oil and gas across various blocks. Prospective basin exploration sites include the shallow-deep water zones in the basin's south-central sector, as well as underexplored terrestrial regions. The exploration history and hydrocarbon resources identified within the West Java back-arc basin support these findings.