Background: We present a detailed description and the preliminary results of our original technique for non-invasive three-dimensional tumor localization in the breast, which was created as an alternative to standard invasive tumor marking before neoadjuvant systemic therapy (NAST), aiming to enable adequate surgery after complete tumor regression. Methods: A detailed description of the technique is provided in the main text. The technique’s feasibility and precision were assessed in a single-arm, prospective study based on the histological parameters of the adequacy and rationality of the excision of completely regressed tumor beds. Results: Out of 94 recruited patients, 15 (16%) were deemed unsuitable, mainly due to the tumors’ inadequate ultrasound visibility. Among the 79 processed patients, 31 (39%) had complete clinical regression after NAST and were operated on using our technique. The histological parameters of surgical precision (signs of tumor regression: 24/31; microscopic cancer residues: 7/31) were verified in all excised specimens (100% precision). There were no positive margins in seven cases with microscopic residues, indicating our technique’s capacity to enable oncologically safe post-NAST surgery. Conclusions: The proposed technique is feasible and satisfactorily accurate in determining the location of regressed tumors, thus representing an alternative to invasive tumor marking, especially in surgical centers lacking trained staff and equipment for invasive marking. The technique’s limitations are mainly related to the inadequate ultrasound visibility of the tumor.

Background/Objectives: Predicting sentinel lymph node (SLN) involvement in breast cancer can reduce unnecessary axillary lymph node dissections (ALND) and facilitate clinical decision-making. This study aimed to: (i) identify independent predictors for SLN metastasis, and (ii) assess the predictive performance of the MSKCC nomogram for SLN positivity in early-stage breast cancer patients. Methods: A retrospective cohort study spanning a six-year period was conducted at a tertiary care oncology department in Belgrade, Serbia. The study included 684 consecutive patients with histologically confirmed primary breast carcinoma, without distant metastasis, who underwent surgical treatment with sentinel lymph node biopsy (SLNB). Results: Out of 684 patients, 198 (29%) were SLN-positive. Among the positive cases, 178 (89.9%) had one positive SLN, 19 (9.6%) had two, and 1 (0.5%) had three. Multivariate logistic regression revealed that lymphovascular invasion and tumor sizes >20 mm significantly increased the risk for SLN involvement. Patients with SLN metastasis had significantly higher MSKCC-predicted probabilities compared to SLN-negative patients (52.1 ± 18.5% vs. 33.1 ± 16.9%, p < 0.001). The area under the receiver operating characteristic curve (AUC) for the nomogram was 0.778 (95% CI: 0.738–0.818; p < 0.001). The nomogram demonstrated acceptable discrimination, with an AUC of 0.778 (95% CI: 0.738–0.818). However, calibration-in-the-large was −0.526 (95% CI: −0.709 to −0.342), indicating systematic overestimation of absolute risk. The calibration slope was 1.152 (95% CI: 0.921–1.383), and the Brier score was 0.174. Conclusions: Lymphovascular invasion and primary tumor size >20 mm are the only independent predictors of SLN metastasis. Furthermore, The MSKCC nomogram demonstrated acceptable discrimination but systematically overestimated absolute SLN-metastasis risk. Recalibration and further validation are required before clinical application in this population.

Introduction: Breast cancer is the most common form of malignancy in women. It affects about one million women worldwide every year and the incidence continues to rise. As a result of the introduction of screening procedures into everyday practice, advanced diagnostic procedures, and modern surgical and oncological treatment, breast cancer is nowadays a well-controlled disease, often completely curable. However, in clinical practice, we do still encounter locally advanced forms of breast cancer with bleeding as a frequent complication of ulcerated tumours. This is a life-threatening emergency that in most cases must be corrected with palliative surgical procedures. The objective: To present the complication of haemorrhage in breast cancer patients to emergency medicine specialists and other doctors, to help them recognise and treat such patients appropriately. Methodology: The PubMed database and Google Scholar were searched for relevant articles based on specific keywords. Conclusion: Recognising haemorrhage as a complication of breast cancer and providing adequate and timely surgical treatment significantly improves the rate of survival and quality of life even in patients with terminal cancer.

Cardiovascular diseases, malignancy, and diabetes mellitus are the most common chronic non-communicable diseases affecting the population in Serbia. According to The Cancer Registry of the Republic of Serbia, breast cancer is the most common cancer affecting women in Serbia. Every year, 4600 women get diagnosed with BC, and 1600 women die from this disease. Every eighth woman in Serbia is diagnosed with BC. This review aims to summarize clinical and theoretical information about breast cancer, metabolic syndrome and cardiovascular risk connection. The literature search was conducted through PubMed, Google Scholar and cross-references in January 2024. We concluded that although there is a well-established connection between cardiovascular risk, metabolic syndrome, inflammation, dyslipidemia, obesity, diabetes mellitus and breast cancer, more multicenter prospective clinical studies are needed to establish the precise association and pathophysiological mechanisms.