Cedric Hameni Nkwayep

Cedric Hameni Nkwayep


Research Focus & Metrics

Academic Career Length

3Years (2024-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 September 2024 in Infectious Disease Modelling
Verified
Journal Article
Open access
CNCedric Hameni Nkwayep
Cedric Hameni Nkwayep
Romain Lucas Glèlè KakaïRomain Lucas Glèlè Kakaï
Romain Lucas Glèlè Kakaï
SBS. Bowong
S. Bowong
This paper deals with the problem of the prediction and control of cholera outbreak using real data of Cameroon. We first develop and analyze a deterministic model with seasonality for the cholera, the novelty of which lies in the incorporation of undetected cases. We present the basic properties of the model and compute two explicit threshold parameters R¯0 and R_0 that bound the effective reproduction number R0, from below and above, that is R_0≤R0≤R¯0. We prove that cholera tends to disappear when R¯0≤1, while when R_0>1, cholera persists uniformly within the population. After, assuming that the cholera transmission rates and the proportions of newly symptomatic are unknown, we develop the EnKf approach to estimate unmeasurable state variables and these unknown parameters using real data of cholera from 2014 to 2022 in Cameroon. We use this result to estimate the upper and lower bound of the effective reproduction number and reconstructed active asymptomatic and symptomatic cholera cases in Cameroon, and give a short-term forecasts of cholera in Cameroon until 2024. Numerical simulations show that (i) the transmission rate from free Vibrio cholerae in the environment is more important than the human transmission and begin to be high few week after May and in October, (ii) 90% of newly cholera infected cases that present the symptoms of cholera are not diagnosed and (iii) 60.36% of asymptomatic are detected at 14% and 86% of them recover naturally. The future trends reveals that an outbreak appeared from July to November 2023 with the number of cases reported monthly peaked in October 2023. An impulsive control strategy is incorporated in the model with the aim to avoid or prevent the cholera outbreak. In the first year of monitoring, we observed a reduction of more than 75% of incidences and the disappearance of the peaks when no control are available in Cameroon. A second monitoring of control led to a further reduction of around 60% of incidences the following year, showing how impulse control could be an effective means of eradicating cholera.

4 June 2024 in Mathematics
Verified
Journal Article
Open access
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YAYannick Sèna AYIHOU
Yannick Sèna AYIHOU
Jonas DoumateJonas Doumate
Jonas Doumate
CNCedric Hameni Nkwayep
Cedric Hameni Nkwayep
STSamuel Bowong Tsakou
Samuel Bowong Tsakou
Romain Lucas Glèlè KakaïRomain Lucas Glèlè Kakaï
Romain Lucas Glèlè Kakaï
African swine fever (ASF) is endemic in many African countries, and its control is challenging because no vaccine or treatment is available to date. Nowadays, mathematical modeling is a key tool in infectious disease studies, complementing traditional biological investigations. In this study, we propose and analyze a mathematical model for the transmission dynamics of African swine fever (ASF) in Benin that considers the free-living virus in the environment. We provide the theoretical results of the model. The study of the model is conducted by first proving that the model is well posed by showing the positivity and the boundedness of solutions as well as the existence and uniqueness of the solution. We compute the control reproduction number Rc as well as the basic reproduction number R0, which helps to analyze the extinction or the persistence of the disease in the pig population. We provide the global attractivity of the disease-free equilibrium and the endemic equilibrium and study their stabilities. After, we estimate some unknown parameters from the proposed model, and the sensitivity analysis is carried out to determine the parameters that influence the control reproduction number. Finally, through numerical simulations, in the current situation, we find that R0=2.78, which implies that the disease will not die out without any control measures and Rc=1.55 showing that the eradication of the disease highly depends on the control measures taken to reduce disease transmission.