Iron (Fe) is considered to be one of the most significant elements due to its wide applications. Recent years have witnessed a burgeoning interest in Fe catalysis as a sustainable and cost-effective alternative to noble metal catalysis in organic synthesis. The abundance and low toxicity of Fe, coupled with its competitive reactivity and selectivity, underscore its appeal for sustainable synthesis. A lot of catalytic reactions have been performed using heterogeneous catalysts of Fe oxide hybridized with support systems like aluminosilicates, clays, carbonized materials, metal oxides or polymeric matrices. This review provides a comprehensive overview of the latest advancements in Fe-catalyzed organic transformation reactions. Highlighted areas include cross-coupling reactions, C–H activation, asymmetric catalysis, and cascade processes, showcasing the versatility of Fe across a spectrum of synthetic methodologies. Emphasis is placed on mechanistic insights, elucidating the underlying principles governing iron-catalyzed reactions. Challenges and opportunities in the field are discussed, providing a roadmap for future research endeavors. Overall, this review illuminates the transformative potential of Fe catalysis in driving innovation and sustainability in organic chemistry, with implications for drug discovery, materials science, and beyond.

Background: The present study investigates the potential bioactivity of twelve experimentally designed C-2 quaternary indolinones against Providencia spp., a bacterial group of the Enterobacteriaceae family known to cause urinary tract infections. The study aims to provide insights into the bioactive properties of the investigated compounds and their potential use in developing novel treatments against Providencia spp. The experimental design of indolinones, combined with their unique chemical structure, makes them attractive candidates for further investigation. The results of this research may contribute to the development of novel therapeutic agents to combat Providencia spp. infections. Methods: The synthesized indolinones (moL1-moL12) are evaluated to identify any superior activity, particularly focusing on moL12, which possesses aza functionality. The antimicrobial activities of all twelve compounds are tested in triplicates against six different Gram-positive and Gram-negative organisms, including P. vermicola (P< 0.05). Computational methods have been employed to assess the pharmacokinetic properties of the compounds. Results: Among the synthesized indolinones, moL12 exhibits superior activity compared to the other compounds with similar skeleton but different functional moieties. All six strains tested, including P. vermicola, demonstrated sensitivity to moL12. Computational studies support the pharmacokinetic properties of moL12, indicating acceptable absorption, distribution, metabolism, excretion, and toxicity characteristics. Conclusion: Utilizing the PPI approach, we have identified a promising target, FabD, in Gram-negative bacteria. Our analysis has shown that moL12 exhibits significant potential in binding with FabD, thereby, might inhibit cell wall formation, and display superior antimicrobial activity compared to other compounds. Consequently, moL12 may be a potential therapeutic agent that could be used to combat urinary tract infections caused by Providencia spp. The findings of this research hold significant promise for the development of new and effective treatments for bacterial infections.

Herein we report the first successful synthesis of ethanol-assisted in situ generated reduced graphene oxide as a support for CuO/NiO nanoparticles.

The present study broadly explores the synthesis, structural characteristics, and catalytic performance of a nanoporous Ni(OH) ₂ /Co ₃ O ₄ heterojunction engineered for efficient enzymatic sensing of hexavalent chromium Cr( vi ).