C-glycosylflavonoids represent a group of oxygen heterocyclic compounds found widespread in a variety of plants. Synthetic organic chemists are now progressively utilizing C-glycosylflavonoid scaffolds due to their high biological potential. The present review deals with advances in C-glycosylflavonoids research, namely establishing a new updated database of the natural occurrence of Cglycosylflavonoids - one hundred and nine new structures have been reported up to 2011. The structural characterization of some novel C-glycosylflavonoids from various plant species is also discussed. The reported organic synthetic routes along with the biosynthetic aspects of C-glycosylflavonoids are also reviewed. Finally the paper underlines the wide range of C-glycosylflavonoid biological activity. The mentioned topics are detailed in particular chapters and are supported in 187 references.

Chronic cannabinoid exposure during adolescence in male rats induces chronic cognitive and emotional impairments. However, the impact of this form of exposure on offspring vulnerability to stress is unknown.The aim of this study was to evaluate the behavioural and epigenetic effects of stress in the offspring of male rats whose fathers were exposed to cannabinoids during adolescence. Male adolescent offspring of Win55,212‐2 (1.2 mg/kg) treated rats were exposed during one week to variable stressors and subjected to behavioural tests of anxiety and episodic‐like memory, followed by an assessment of global DNA methylation and expression of DNA methyltransferases enzymes DNMT1 and DNMT3a mRNA in the prefrontal cortex.Stress exposure induced a significant anxiogenic‐like effect but did not affect the episodic‐like memory in the offspring of Win55,212‐2 exposed fathers in comparison to the offspring of non‐exposed fathers. These behavioural changes were subsequent to a significant increase in global DNA methylation and DNMT1 and DNMTa3 transcription in the prefrontal cortex.These data suggest that the deleterious effect of chronic exposure to cannabinoids during adolescence are not limited to the exposed individuals but may increase the vulnerability to stress‐induced anxiety in the offspring and alter their epigenetic programming.