Guoxiong Peng

Prof. Dr. Guoxiong Peng

orcid

Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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13 July 2023 in Journal of Fungi
Verified
Journal Article
Open access
PDF file
YQYujie Qin
Yujie Qin
XLXiaoyu Liu
Xiaoyu Liu
Guoxiong PengGuoxiong Peng
Guoxiong Peng
YXYuxian Xia
Yuxian Xia
YCYueqing Cao
Yueqing Cao
Fungal diseases are widespread among insects and play a crucial role in naturally regulating insect populations. Mosquitoes, known as vectors for numerous infectious diseases, pose a significant threat to human health. Entomopathogenic fungi (EPF) have emerged as highly promising alternative agents to chemical mosquitocides for controlling mosquitoes at all stages of their life cycle due to their unique infection pathway through direct contact with the insect’s cuticle. In recent years, significant advancements have been made in understanding the infection pathways and pathogenic mechanisms of EPF against mosquitoes. Various strategies involving the use of EPF alone or combinations with other approaches have been employed to target mosquitoes at various developmental stages. Moreover, the application of genetic technologies in fungi has opened up new avenues for enhancing the mosquitocidal efficacy of EPF. This review presents a comprehensive summary of recent advancements in our understanding the pathogenic mechanisms of EPF, their applications in mosquito management, and the combination of EPF with other approaches and employment of transgenic technologies. The biosafety concerns associated with their use and the corresponding approaches are also discussed. The recent progress suggests that EPF have the potential to serve as a future biorational tool for controlling mosquito vectors.


10 February 2011 in BMC Microbiology
Verified
Journal Article
Open access
PDF file
YLYajun Leng
Yajun Leng
Guoxiong PengGuoxiong Peng
Guoxiong Peng
YCYueqing Cao
Yueqing Cao
YXYuxian Xia
Yuxian Xia
Background: The entomopathogenic fungus Metarhizium acridum has been used as an important biocontrol agent instead of insecticides for controlling crop pests throughout the world. However, its virulence varies with environmental factors, especially temperature. Neutral trehalase (Ntl) hydrolyzes trehalose, which plays a role in environmental stress response in many organisms, including M. acridum. Demonstration of a relationship between Ntl and thermotolerance or virulence may offer a new strategy for enhancing conidiospore thermotolerance of entomopathogenic fungi through genetic engineering. Results: We selected four Ntl over-expression and four Ntl RNA interference (RNAi) transformations in which Ntl expression is different. Compared to the wild-type, Ntl mRNA expression was reduced to 35-66% in the RNAi mutants and increased by 2.5-3.5-fold in the over-expression mutants. The RNAi conidiospores exhibited less trehalase activity, accumulated more trehalose, and were much more tolerant of heat stress than the wild-type. The opposite effects were found in conidiospores of over-expression mutants compared to RNAi mutants. Furthermore, virulence was not altered in the two types of mutants compared to the wild type. Conclusions: Ntl controlled trehalose accumulation in M. acridum by degrading trehalose, and thus affected conidiospore thermotolerance. These results offer a new strategy for enhancing conidiospore thermotolerance of entomopathogenic fungi without affecting virulence.


30 April 2020 in Journal of Pest Science
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Journal Article
Closed access
PDF file
JLJun Li
Jun Li
Jiaqin XieJiaqin Xie
Jiaqin Xie
DZDeyu Zeng
Deyu Zeng
YXYuxian Xia
Yuxian Xia
Guoxiong PengGuoxiong Peng
Guoxiong Peng

24 February 2020 in Pest Management Science
Verified
Journal Article
Closed access
PDF file
Guoxiong PengGuoxiong Peng
Guoxiong Peng
STSen‐Miao Tong
Sen‐Miao Tong
DZDeyu Zeng
Deyu Zeng
YXYuxian Xia
Yuxian Xia
Ming-guang FengMing-guang Feng
Ming-guang Feng