With the rapid development of deepfake technology, it is finding applications in virtual movie production and entertainment. However, its potential for malicious use, such as generating false information, fake news, or synthetic pornography, poses significant threats to national and social security. Various research disciplines are actively engaged in developing deepfake video detection technologies to mitigate the risks associated with malicious deepfake content. Therefore, the importance of deepfake video detection technology cannot be overemphasized. This study addresses the challenge posed by images in nonexistent datasets by analyzing deepfake video detection methods. Using temporal and spatial detection techniques and employing 68 facial landmarks for alignment and feature extraction, this research integrates the attention-guided data augmentation (AGDA) strategy to enhance generalization capabilities. The detection performance is evaluated on four datasets: UADFV, FaceForensics++, Celeb-DF, and DFDC, with superior results compared to alternative approaches. To evaluate the study’s ability to accurately discriminate authenticity, detection experiments are conducted on both genuine and deepfake videos synthesized using the DeepFaceLab and FakeApp frameworks. The experimental results show better performance in detecting deepfake videos than other methods compared.