Surajit Das

Dr. Surajit Das

orcid

Research Focus & Metrics

Academic Career Length

17Years (2010-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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21 December 2010 in AAPS PharmSciTech
Verified
Journal Article
Closed access
PDF file
SDSurajit Das
Surajit Das
ACAnumita Chaudhury
Anumita Chaudhury

1 August 2012 in European Journal of Pharmaceutical Sciences
Verified
Journal Article
Closed access
SDSurajit Das
Surajit Das
WNWai Kiong Ng
Wai Kiong Ng
RTReginald B.H. Tan
Reginald B.H. Tan

1 November 2011 in Colloids and Surfaces B: Biointerfaces
Verified
Journal Article
Closed access
SDSurajit Das
Surajit Das
WNWai Kiong Ng
Wai Kiong Ng
PKParijat Kanaujia
Parijat Kanaujia
SKSanggu Kim
Sanggu Kim
RTReginald B.H. Tan
Reginald B.H. Tan


23 July 2020 in Scientific Reports
Verified
Journal Article
Open access
PDF file
SDSurajit Das
Surajit Das
AWAnnie B. H. Wong
Annie B. H. Wong
Ferulic acid is a potent anti-oxidant with scientifically proven skin care efficacies. However, instability of this active in the skin care products restricted its wide application in beauty and skin care industries. This study aimed to stabilize ferulic acid in topical hydrogel formulation via nanoencapsulation technique. Ferulic acid loaded nanocapsules were prepared via high pressure homogenization method and physicochemically characterized. Mean particle size of ferulic acid loaded nanocapsules was < 300 nm. TEM and SEM images exhibited spherical particles with smooth surface. DSC and XRD results indicated that ferulic acid was completely dissolved in the lipid matrix of the nanocapsules and remained in amorphous form. Two types of hydrogel formulations containing ferulic acid loaded nanocapsules were prepared: Gel A with pH higher and Gel B with pH lower than pKa of ferulic acid. Cross-polarized microscopic image of the gel formulations did not show presence of any un-encapsulated and un-dissolved crystal. Gel B showed slower and controlled release of ferulic acid than Gel A. Ferulic acid permeation through skin mimic from the gel formulation demonstrated controlled permeation. Color stability of the gel and chemical stability of ferulic acid were very good in Gel B, while poor in Gel A (although significantly better than the gel with un-encapsulated ferulic acid). The result clearly indicates that together with nanoencapsulation, low pH (less than pKa of ferulic acid) of the hydrogel was crucial for both product appearance and chemical stability of ferulic acid. In fact, it has been proved that skin care product with low pH is good for skin as it can maintain skin homeostasis and microbiome. Furthermore, the permeation result suggests that ferulic acid may penetrate into deep skin layers and at the same time avoid systemic circulation. Overall, this low pH hydrogel formulation containing nanoencapsulated ferulic acid demonstrates great promise for commercialization.

1 May 2020 in Colloids and Surfaces B: Biointerfaces
Verified
Journal Article
Closed access
SDSurajit Das
Surajit Das
SLSie Huey Lee
Sie Huey Lee
VCVernissa Dilys Chia
Vernissa Dilys Chia
PCPui Shan Chow
Pui Shan Chow
CMCalum Macbeath
Calum Macbeath
GSGeorge Shlieout
George Shlieout