This cross-sectional study assessed the global health needs of children aged 2 to 6 years and examined how socio-demographic characteristics influenced children's health needs observed following the COVID-19 pandemic. Cross-sectional study conducted between January and March 2021 in three regions of northern Spain with similar household incomes. Participants were selected through one-stage cluster sampling. A self-reported questionnaire, Necesidades de salud de la Población Infantil, was used to assess children's health needs across seven dimensions and 125 items. A total of 301 parents or caregivers completed the questionnaire. The dimensions parental self-efficacy, professional advice, child socio-emotional aspects, and situational influence were the most frequently reported as significant, while parent socio-emotional aspects, lifestyle, promotion of healthy lifestyles, and influence of significant people were the least emphasized. Life-style-related needs were particularly affected by the limited access to healthcare professionals and were more pronounced when children had a disability. The findings of this study provide valuable insights for the development of strategies, programs, and interventions aimed at promoting children's health by addressing the identified needs.