In the present scenario, obesity is a challenging health problem and its prevalence along with comorbidities are on the rise around the world. According to world health organization and organisation for economic co-operation and development epidemiology reports, overweight and obesity are the fifth foremost causes of deaths globally. The increasing rate of obesity is becoming a mammoth problem which enormously affects an individual's quality of life. The conventional therapy of obesity mainly involves synthetic moieties and surgical procedures, which has many harmful side effects and chances of recurrence with severity. Hence, the Present review is a metanalysis of all the available data on the use of the plants with their biological source, active phytochemical constituents and a probable mechanism of action as natural anti-obesity agents. The metanalysis of data during the period of 2000-2018 was performed with the help of scientific data search engine National Center for Biotechnology Information (NCBI/PubMed). This data reveals the need and scope of further research in the development of new natural phytoconstituents for the management of obesity.

In every developed and developing country, the major facing problem is heavy metals toxicity. Due to there is an increase in the heavy metals anthropogenic in day to day life by various factors, which are causing serious issues or harmful health hazardous for all types of living organisms. Moreover, they are present everywhere in the universe it causes the contamination of the food, dietary, and processed materials. Accordingly, the present review article further summarizes the studies related to the determination of lead as a toxic impurity with a total of 134 references in the period 2000 to 2018. In this write-up, emphasize the one of the highly toxic heavy metal element Lead (Pb) and it’s toxicity in the animals, humans, plants, and aquatic systems. In addition, the purpose of this article is to evaluate the effectiveness of established analytical techniques and trends in analytical methods like AAS; ICP-OES; ICP-MS; ASV; X-ray fluorescence spectrometry, these techniques significantly applicable for the quantitative analysis of Pb in various sources. The various regulatory authorities for Pb throughout the globe like IOSH, EPA, EMA, and CDCSO. This reveals the need and scope of further research in the field of heavy metal toxicity and development of new analytical techniques in meeting the needs of the life scientists. The present comprehensive review is an attempt to transform the state of knowledge into the findings that may act as a guideline for all the interested groups at different levels.

Background: Urolithiasis is the most common renal system pathology; it affects the health of a many people. Because urolithiasis leads to severe pain, it influences the patient in many aspects. The management of urolithiasis is essential. Herein, we discuss the limitations of the management of urolithiasis with conventional drugs and the possibilities of using natural or herbal pharmacologically active agents beyond conventional drugs. Purpose: The drugs presently used for the treatment of urolithiasis have many adverse side effects; therefore, alternatives are needed. Traditional literature suggests that many herbal or natural medicines can be easily made available for the management of urolithiasis and its consequences. Method: The data used for this study were collected from various research /review articles, Internet sources, and text books. Literature regarding epidemiology and pharmacological studies performed by various researchers were taken into consideration in this review. The data from the last few decades, reported in different formats, were analyzed. Conclusion: The present review reveals the severity of the progression of the occurrence of urolithiasis worldwide. The epidemiology gave in this review clearly indicates that stress-related factors and dietary complications, the key factors in the development of urolithiasis. are increasing. In this review, we acknowledge the limitations of conventional therapy. Many natural drug options are abundantly available throughout the world and can be useful for the management of urolithiasis. Future Perspectives: The development of a suitable formulation of bioactive components obtained from natural sources is being widely researched. However, traditional remedies that are very helpful in the management of urolithiasis and its related complications require scientific support and appropriate standardization for the assessment of their quality and dosage.