The introduction of pulse oximetry in the 1970s provided a new vital sign to physicians for monitoring patient care.
1, 2, 3 While easy to use and relatively inexpensive, pulse oximetry only monitors arterial oxygenation. More recent advances in modeling and instrumentation have led to the development of quantitative spectroscopic probes capable of measuring total tissue oxygenation (arterial & venous).
4, 5, 6, 7, 8, 9 However, these devices typically provide local measurements and require
a priori knowledge of the location of a potential oxygenation defect. Thus, an imaging system that offers truly passive monitoring by measuring large areas of tissue oxygenation without
a priori knowledge would aid patient management in many surgical and critical care applications.