Metal–organic frameworks (MOFs) are porous coordination materials composed of multidentate organic ligands and metal ions or metal clusters. MOFs have the great potential to be utilized in antibacterial materials for biological, environmental, and food antimicrobial fields. In recent years, MOFs have been applied to various antibacterial fields due to their sustained release capability, porosity, and structural flexibility in combination with many chemicals and/or materials (such as nanoparticles, antibiotics, phytochemicals, and polymers). This review offers a detailed summary of the antibacterial applications of MOFs and their composites, focusing on the combination types of MOFs composites and the antibacterial effect in different applications. These applications are illustrated by the examples discussed in this review.