Dr. Ewy Mathe is the director of informatics in NCATS' Division of Preclinical Innovation, where she leads a diverse team of experts in bioinformatics, cheminformatics, data science, and software development. Prior to joining NCATS in 2020, she was a faculty member in the Department of Biomedical Informatics at the Ohio State University, where she developed analytical approaches for the analysis and interpretation of metabolomics data, including integration of metabolomics with gene expression, microbiome, and epigenomics data. She received a bachelor’s degree in biochemistry (minor in sociology) from Mount St. Mary’s University in Emmitsburg, Maryland, in 2000, and a doctorate in bioinformatics from George Mason University in Fairfax, Virginia, in 2006. During her postdoctoral training at the National Cancer Institute with Curtis C. Harris, M.D., she discovered putative esophageal and lung cancer biomarkers using microRNA microarrays and metabolomics. She then joined the laboratory of Rafael C. Casellas, Ph.D., at the National Institute of Arthritis and Musculoskeletal and Skin Diseases, where she used next-generation sequencing techniques to better understand the modalities of transcriptional regulation in B lymphocytes.