The Eighth Mount Hood Challenge (held in St. Gallen, Switzerland, in September 2016) evaluated the transparency of model input documentation from two published health economics studies and developed guidelines for improving transparency in the reporting of input data underlying model-based economic analyses in diabetes. Participating modeling groups were asked to reproduce the results of two published studies using the input data described in those articles. Gaps in input data were filled with assumptions reported by the modeling groups. Goodness of fit between the results reported in the target studies and the groups' replicated outputs was evaluated using the slope of linear regression line and the coefficient of determination (R2). After a general discussion of the results, a diabetes-specific checklist for the transparency of model input was developed. Seven groups participated in the transparency challenge. The reporting of key model input parameters in the two studies, including the baseline characteristics of simulated patients, treatment effect and treatment intensification threshold assumptions, treatment effect evolution, prediction of complications and costs data, was inadequately transparent (and often missing altogether). Not surprisingly, goodness of fit was better for the study that reported its input data with more transparency. To improve the transparency in diabetes modeling, the Diabetes Modeling Input Checklist listing the minimal input data required for reproducibility in most diabetes modeling applications was developed. Transparency of diabetes model inputs is important to the reproducibility and credibility of simulation results. In the Eighth Mount Hood Challenge, the Diabetes Modeling Input Checklist was developed with the goal of improving the transparency of input data reporting and reproducibility of diabetes simulation model results.

The objectives of the present study were to determine, for Nile tilapia of different body weights and fed to satiation, (1) the incipient dissolved oxygen (DO) concentration at which feed intake starts to level off and (2) the effect of DO on nitrogen and energy balances. Two successive experiments were conducted with two weight classes of male Nile tilapia (>200 g, Experiment 1, and <100 g, Experiment 2). Twelve aquaria were assigned to four DO levels in each experiment. Fish were fed to apparent satiation for 16 and 20 days in Experiments 1 and 2 respectively. The DO-feed intake curve of fish200 g continued to increase as DO increased from 2.6 to 6.0 mg L⁻¹. The latter curve suggests that the incipient DO for fish>200 g is about 5.5 mg L⁻¹. Fish tended to reduce the energy requirement for maintenance as DO declined. A DO reduction caused an increase in the apparent digestibility coefficient (ADC), but further declines in DO to levels below a critical level decreased ADC. The DO did not have a considerable effect on the metabolizable energy: digestible energy ratio of the diet.