Near‐infrared‐II (NIR‐II) ferroptosis activators offer promising potentials in in vivo theranostics of deep tumors, such as glioma. However, most cases are nonvisual iron‐based systems that are blind for in vivo precise theranostic study. Additionally, the iron species and their associated nonspecific activations might trigger undesired detrimental effects on normal cells. Considering gold (Au) is an essential cofactor for life and it can specifically bind to tumor cells, Au(I)‐based NIR‐II ferroptosis nanoparticles (TBTP‐Au NPs) for brain‐targeted orthotopic glioblastoma theranostics are innovatively constructed. It achieves the real‐time visual monitoring of both the BBB penetration and the glioblastoma targeting processes. Moreover, it is first validated that the released TBTP‐Au specifically activates the effective heme oxygenase‐1‐regulated ferroptosis of glioma cells to greatly extend the survival time of glioma‐bearing mice. This new ferroptosis mechanism based on Au(I) may open a new way for the fabrication of advanced and high‐specificity visual anticancer drugs for clinical trials.

A pH-responsive and hydrophilic Al(OH)₃mediating layer makes possible the promising integration of photothermal therapy and fluorescence imaging based on upconversion nanoparticles (UCNPs).

Near-infrared (NIR) fluorescence probes featuring ultralarge Stokes shifts and efficient aggregate-state luminescence are highly desirable for bioimaging yet remain scarce due to formidable synthetic challenges and intricate photophysical modulation. We report a facile one-step click reaction to synthesize a tetracyanoquinodimethane-derived NIR probe (TNQ2) that overcomes the long-standing nonfluorescence limitation while achieving an unprecedented 445-nanometer Stokes shift. TNQ2 self-assembles into the smallest-sized two-dimensional J -aggregates (sub-160 nanometers) with a red-shift absorption from 545 to 725 nanometers and aggregation-enhanced emission around 1000 nanometers. The radiative/nonradiative modulation balances the fluorescence/photothermal/photodynamic effect to support high-sensitivity NIR-II fluorescence imaging-guided precise glioma resection and postoperative phototherapy to substantially extend survival in orthotopic glioma models. Our molecule/nanoengineering strategy establishes a transformative paradigm for developing advanced NIR phototheranostics for brain diseases.

Surface plasmon resonance (SPR) photocatalysts have attracted considerable attention because of their strong absorption capacity of visible light and enhanced photogenic carrier separation efficiency. However, the separate production of metal nanoparticles (NPs) and semiconductors limits the photogenic charge transfer. As one of the most promising organic photocatalysts, porphyrin self-assemblies with a long-range ordered structure-enhance electron transfer. In this study, plasmonic noble metal-based porphyrin hexagonal submicrowires composites (M-HW) loaded with platinum (Pt), silver (Ag), gold (Au), and palladium (Pd) NPs were synthesized through a simple in situ photocatalytic method. Homogeneous and uniformly distributed metal particles on the M-HW composites enhanced the catalytic or chemical properties of the organic functional nanostructures. Under the same loading of metal NPs, the methyl orange photocatalytic degradation efficiency of Ag-HW [k_Ag-HW (0.043 min⁻¹)] composite was three times higher than that of HW, followed by Pt-HW [k_Pt-HW (0.0417 min⁻¹)], Au-HW [k_Au-HW (0.0312 min⁻¹)], and Pd-HW [k_Pd-HW (0.0198 min⁻¹)]. However, the rhodamine B (RhB) and eosin B photocatalytic degradations of Pt-HW were 4 times and 2.6 times those of HW, respectively. Finally, the SPR-induced electron injection, trapping, and recombination processes of the M-HW system were investigated. These results showed that M-HW plasmonic photocatalysts exhibited excellent photocatalytic performances, making them promising materials for photodegrading organic pollutants.

Photoactive artificial nanocatalysts that mimic natural photoenergy systems can yield clean and renewable energy. However, their poor photoabsorption capability and disfavored photogenic electron–hole recombination hinder their production. Herein, we designed two nanocatalysts with various microstructures by combining the tailored self-assembly of the meso-tetra(p-hydroxyphenyl) porphine photosensitizer with the growth of titanium dioxide (TiO₂). The porphyrin photoabsorption antenna efficiently extended the absorption range of TiO₂ in the visible region, while anatase TiO₂ promoted the efficient electron–hole separation of porphyrin. The photo-induced electrons were transferred to the surface of the Pt co-catalyst for the generation of hydrogen via water splitting, and the hole was utilized for the decomposition of methyl orange dye. The hybrid structure showed greatly increased photocatalytic performance compared to the core@shell structure due to massive active sites and increased photo-generated electron output. This controlled assembly regulation provides a new approach for the fabrication of advanced, structure-dependent photocatalysts.