Ecotourism is becoming more and more significant because it aids in environmental protection and maintaining the sustainable growth of a region. Mizoram is known for its potentially varied landscapes, which draw visitors from many nations and territories. The Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) approach was used in this study to evaluate land suitability for ecotourism initiatives in Mizoram spatially. The study also focused on role weighting (subjective, objective, and intergraded) on the decision-making process. In this regard, the weightage of twelve ecotourism influencing factors was determined to integrate with the TOPSIS model and the Geographical Information System (GIS) environment. As a result, five hierarchical ecotourism zones, including very high to very low, have been classified using Jenks’s natural breaking classification. The model’s accuracy based on the area under the curve (AUC) and receiver operating characteristic (ROC) curve revealed that all models successfully predict potential ecotourism in the marginal hilly region. As a result, the intergrade weighting combined TOPSIS model showed that 25.18% of the study region has very highly suitable for ecotourism. The results of this study may be used as a foundation for assessing the feasibility of resources suitable for ecotourism development by government officials and planners.