It was purposed to evaluate the biological potential of ethanol and isopropanol crude extracts of ripe Physalis peruviana fruits. Cytotoxic and immunomodulatory effects of the expression of interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 (MCP-1) were evaluated on human cervical cancer (HeLa) and murine fibroblast (L929) cells. The composition was evaluated by high-performance liquid chromatography diode-array detection and high-performance liquid chromatography ultraviolet/visible detection. The presence of ursolic acid and rosmarinic acid was found in both solvents. However, gallic acid, quercetin, and epicatechin were higher in isopropanol extracts ( P < .05). The results indicated a relationship among the total polyphenol content, antioxidant activity, and cytotoxic activity that was dependent on the solvent used. Isopropanol extracts presented a half-maximal inhibition concentration value (IC₅₀) of 60.48 ± 3.8 μg/mL for HeLa cells and 66.62 ± 2.67 μg/mL for L929 fibroblasts. The extracts reduced the release of interleukin-6, interleukin-8, and MCP-1 in a dose-dependent manner. Extracts showed anticancer and immunomodulatory potential for new complementary pharmaceutical products development.

Background: Older people are at risk of malnutrition, especially when they suffer from cognitive impairment. Guidelines that orient nursing care in this regard need to be updated. The aim of this review is to address the best available evidence on interventions that can benefit nutritional nursing care for institutionalized older adults with dementia. Methods: Integrative review using the Dimensions and Eureka search engines, and the PubMed, Embase, Scielo, CINAHL, and ScienceDirect databases. We searched from the year 2015 through to 2021. We employed the MMAT guidelines for mixed, qualitative, and quantitative studies, and the PRISMA, CASP, and JBI guidelines to value the reviews. Results: A total of 55 studies met the inclusion criteria. The best available evidence to support nutritional nursing care for institutionalized older adults with dementia highlights several aspects related to the assessment and caring interventions that are focused on people with dementia, their caregivers, and their context. Conclusions: Both the assessment and nutritional care interventions for older people with dementia should consider the patient–caregiver dyad as the subject of care and understand the context as a fundamental part of it. The analysis of the context should look further than the immediate environment.

The improvement in the nutritional status of older adults with swallowing limitations, as could happen in Alzheimer’s, has prompted modified-texture food design, including thick liquids that reduce the risk of aspiration. National Dysphagia Diet and the International Dysphagia Diet Standardization Initiative classified food accordingly with dysphagia severity level by literature sources without considering preparation and service conditions. The rheological and mechanical behavior of 34 liquid, 35 semisolid, and solid food commonly included in elderly menus was categorized by dysphagia severity level, considering preparation conditions and evaluation at service temperature. Data were fitted to the Power Law and Herschel-Bulkley models. Rheological behavior found thixotropic and pseudoplastic fluids in the range of 0.13 < n < 0.69; 0.48 < K < 62081, without elastic limit. Solid and semisolid food were classified by hardness as 4-pureed (H ≤ 15000), 5-Minced & moist, and 6-Soft & bite-sized (15000 ≤ H ≤ 40000), 7-Regular-Easy to chew (H > 40000). Analyzing the rheological and mechanical behavior attributes allowed the categorization by type of dysphagia. Outcomes for food with individualized attributes are useful for older adult caregivers at home and in professional clinical care, emphasizing people with cognitive impairment, including Alzheimer’s.

Background/Objective: Although the context, personal conditions, and caregivers’ abilities influence the nutrition of older people with dementia, adequate parameters are not always applied to identify these conditions. The aim of this study was to characterize the nutritional care needs of older people with dementia and their caregivers. Method: This descriptive exploratory study was conducted in Colombia. An intentional sample included 73 elderly individuals with dementia and 73 caregivers. This study described the participants’ characteristics with the GCPC-UN-D survey. Their nutritional conditions include medical history, objective tests, and interviews. We used the Edinburgh Scale to evaluate elderly feeding behavior and the QUALID tool to evaluate their quality of life. This study measured caregiver competence using the CUIDAR tool. Results: Adults of 78.8 years on average, with low to middle socio-economic status, low education levels, and multiple comorbidities, have adverse well-being and support conditions, except for the spiritual component. These adults have visible nutritional issues including low muscle mass indices (47.9%), muscle mass levels (arm 61.6%; calf 58.9%), and vitamin D levels (50.7%), with high cholesterol levels (57.9%) and altered hematocrit and red blood cell counts (46.4%). These adults required supervision (41%) or help (23%) for their nutrition. Caregivers were predominantly women with an average age of 32.4 years, with moderate caregiving competences (70.43%), experienced high caregiver burden (83.6%), and had low orientation in nutritional management (30.1%). Conclusions: Elderly individuals with dementia had significant nutritional and feeding problems. Their caregivers lacked adequate conditions to ensure quality care. These dyads need a strategy to improve their healthcare experience.