Makoto Ito

Prof. Dr. Makoto Ito

orcid

Research Focus & Metrics

Academic Career Length

13Years (2014-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 October 2017 in Auris Nasus Larynx
Verified
Journal Article
Closed access
MIMakoto Ito
Makoto Ito
HTHaruo Takahashi
Haruo Takahashi
YIYukiko Iino
Yukiko Iino
HKHiromi Kojima
Hiromi Kojima
SHSho Hashimoto
Sho Hashimoto
TNTakeo Nakayama
Takeo Nakayama

28 March 2024 in JMIR Medical Education
Verified
Journal Article
Open access
MNMasao Noda
Masao Noda
TUTakayoshi Ueno
Takayoshi Ueno
RKRyota Koshu
Ryota Koshu
YTYuji Takaso
Yuji Takaso
MSMari Dias Shimada
Mari Dias Shimada
TYTomokazu Yoshizaki
Tomokazu Yoshizaki
Background: Artificial intelligence models can learn from medical literature and clinical cases and generate answers that rival human experts. However, challenges remain in the analysis of complex data containing images and diagrams. Objective: This study aims to assess the answering capabilities and accuracy of ChatGPT-4 Vision (GPT-4V) for a set of 100 questions, including image-based questions, from the 2023 otolaryngology board certification examination. Methods: Answers to 100 questions from the 2023 otolaryngology board certification examination, including image-based questions, were generated using GPT-4V. The accuracy rate was evaluated using different prompts, and the presence of images, clinical area of the questions, and variations in the answer content were examined. Results: The accuracy rate for text-only input was, on average, 24.7% but improved to 47.3% with the addition of English translation and prompts (P<.001). The average nonresponse rate for text-only input was 46.3%; this decreased to 2.7% with the addition of English translation and prompts (P<.001). The accuracy rate was lower for image-based questions than for text-only questions across all types of input, with a relatively high nonresponse rate. General questions and questions from the fields of head and neck allergies and nasal allergies had relatively high accuracy rates, which increased with the addition of translation and prompts. In terms of content, questions related to anatomy had the highest accuracy rate. For all content types, the addition of translation and prompts increased the accuracy rate. As for the performance based on image-based questions, the average of correct answer rate with text-only input was 30.4%, and that with text-plus-image input was 41.3% (P=.02). Conclusions: Examination of artificial intelligence’s answering capabilities for the otolaryngology board certification examination improves our understanding of its potential and limitations in this field. Although the improvement was noted with the addition of translation and prompts, the accuracy rate for image-based questions was lower than that for text-based questions, suggesting room for improvement in GPT-4V at this stage. Furthermore, text-plus-image input answers a higher rate in image-based questions. Our findings imply the usefulness and potential of GPT-4V in medicine; however, future consideration of safe use methods is needed.

31 May 2024 in JMIR AI
Verified
Journal Article
Open access
MNMasao Noda
Masao Noda
HYHidekane Yoshimura
Hidekane Yoshimura
TOTakuya Okubo
Takuya Okubo
RKRyota Koshu
Ryota Koshu
Yuki UchiyamaYuki Uchiyama
Yuki Uchiyama
YTYutaka Takumi
Yutaka Takumi
Background: The integration of artificial intelligence (AI), particularly deep learning models, has transformed the landscape of medical technology, especially in the field of diagnosis using imaging and physiological data. In otolaryngology, AI has shown promise in image classification for middle ear diseases. However, existing models often lack patient-specific data and clinical context, limiting their universal applicability. The emergence of GPT-4 Vision (GPT-4V) has enabled a multimodal diagnostic approach, integrating language processing with image analysis. Objective: In this study, we investigated the effectiveness of GPT-4V in diagnosing middle ear diseases by integrating patient-specific data with otoscopic images of the tympanic membrane. Methods: The design of this study was divided into two phases: (1) establishing a model with appropriate prompts and (2) validating the ability of the optimal prompt model to classify images. In total, 305 otoscopic images of 4 middle ear diseases (acute otitis media, middle ear cholesteatoma, chronic otitis media, and otitis media with effusion) were obtained from patients who visited Shinshu University or Jichi Medical University between April 2010 and December 2023. The optimized GPT-4V settings were established using prompts and patients’ data, and the model created with the optimal prompt was used to verify the diagnostic accuracy of GPT-4V on 190 images. To compare the diagnostic accuracy of GPT-4V with that of physicians, 30 clinicians completed a web-based questionnaire consisting of 190 images. Results: The multimodal AI approach achieved an accuracy of 82.1%, which is superior to that of certified pediatricians at 70.6%, but trailing behind that of otolaryngologists at more than 95%. The model’s disease-specific accuracy rates were 89.2% for acute otitis media, 76.5% for chronic otitis media, 79.3% for middle ear cholesteatoma, and 85.7% for otitis media with effusion, which highlights the need for disease-specific optimization. Comparisons with physicians revealed promising results, suggesting the potential of GPT-4V to augment clinical decision-making. Conclusions: Despite its advantages, challenges such as data privacy and ethical considerations must be addressed. Overall, this study underscores the potential of multimodal AI for enhancing diagnostic accuracy and improving patient care in otolaryngology. Further research is warranted to optimize and validate this approach in diverse clinical settings.

11 September 2023 in JMIR mHealth and uHealth
Verified
Journal Article
Open access
MNMasao Noda
Masao Noda
TKTatsuaki Kuroda
Tatsuaki Kuroda
ANAkihiro Nomura
Akihiro Nomura
MIMakoto Ito
Makoto Ito
TYTomokazu Yoshizaki
Tomokazu Yoshizaki
HFHiroaki Fushiki
Hiroaki Fushiki
Background: Dizziness and vertigo can be caused by various factors, such as peripheral vestibular and central disorders. Although consultations with specialists are advisable when necessary, patients with severe vertigo symptoms may have limited mobility, which may interfere with hospital visits. The spread of COVID-19 has further limited the number of hospital visits for patients with dizziness; therefore, a method of medical care that enables more accurate treatment under time and geographical constraints is needed. Telemedicine has become widespread, owing to the popularity of smartphone and tablet devices in recent years, and the use of devices and systems has made it possible to provide efficient medical care. However, no previous scoping review has mapped existing studies on telemedicine for vertigo and dizziness, and no recommendations have been made regarding which devices and systems should be used for specific diseases.Objective: The aim of this review was to map and assess previous studies on the use of information communications technology, smartphones, and apps for treating patients with vertigo and discuss the added value of introducing telemedicine to improve the quality of medical care and create an environment that builds security and trust among patients.Methods: A scoping review was conducted with the methodological framework of Arksey and O’Malley and in accordance with the of the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews) guidelines. The PubMed, MEDLINE, and Cochrane Library databases were searched to retrieve previous reports on smartphone-assisted telemedicine treatment for vertigo published between January 2000 and May 2023. Two authors independently assessed eligibility and extracted data.Results: This review included 20 papers that reported devices or systems for telemedicine for vestibular dysfunction. Among studies that reported the use of a device or app, 2 were related to anamnesis and subjective symptoms, 12 were related to objective examination, 7 were related to remote diagnosis, and 7 were related to treatment and rehabilitation.Conclusions: With the advancement of technology, the use of telemedicine in patients with dizziness may be feasible. In the future, it will be necessary to consider how telemedicine can be used in dizziness treatment and develop an effective treatment system combining in-person medical care and the effective use of devices for the management of severe vertigo and related diseases. The smooth introduction of telemedicine in vertigo treatment is expected to improve the quality of treatment, increase opportunities for patients to receive medical care, and reduce time and travel costs, leading to a sense of security and trust among patients.

1 December 2014 in Auris Nasus Larynx
Verified
Journal Article
Closed access
HSHisashi Sugimoto
Hisashi Sugimoto
MIMakoto Ito
Makoto Ito
MHMiyako Hatano
Miyako Hatano
TYTomokazu Yoshizaki
Tomokazu Yoshizaki

6 June 2025 in JMIR Formative Research
Verified
Journal Article
Open access
MNMasao Noda
Masao Noda
RKRyota Koshu
Ryota Koshu
RTReiko Tsunoda
Reiko Tsunoda
HOHirofumi Ogihara
Hirofumi Ogihara
TKTomohiko Kamo
Tomohiko Kamo
HFHiroaki Fushiki
Hiroaki Fushiki
Background: Conventional nystagmus classification methods often rely on subjective observation by specialists, which is time-consuming and variable among clinicians. Recently, deep learning techniques have been used to automate nystagmus classification using convolutional and recurrent neural networks. These networks can accurately classify nystagmus patterns using video data. However, associated challenges including the need for large datasets when creating models, limited applicability to address specific image conditions, and the complexity associated with using these models. Objective: This study aimed to evaluate a novel approach for nystagmus classification that used the Generative Pre-trained Transformer 4 Vision (GPT-4V) model, which is a state-of-the-art large-scale language model with powerful image recognition capabilities. Methods: We developed a pupil-tracking process using a nystagmus-recording video and verified the optimization model’s accuracy using GPT-4V classification and nystagmus recording. We tested whether the created optimization model could be evaluated in six categories of nystagmus: right horizontal, left horizontal, upward, downward, right torsional, and left torsional. The traced trajectory was input as two-dimensional coordinate data or an image, and multiple in-context learning methods were evaluated. Results: The developed model showed an overall classification accuracy of 37% when using pupil-traced images and a maximum accuracy of 24.6% when pupil coordinates were used as input. Regarding orientation, we achieved a maximum accuracy of 69% for the classification of horizontal nystagmus patterns but a lower accuracy for the vertical and torsional components. Conclusions: We demonstrated the potential of versatile vertigo management in a generative artificial intelligence model that improves the accuracy and efficiency of nystagmus classification. We also highlighted areas for further improvement, such as expanding the dataset size and enhancing input modalities, to improve classification performance across all nystagmus types. The GPT-4V model validated only for recognizing still images can be linked to video classification and proposed as a novel method.