Khouloud Rouzi

Dr. Khouloud Rouzi


Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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5 September 2023 in Reactions
Verified
Journal Article
Open access
PDF file
IHIssam AMEZIANE EL HASSANI
Issam AMEZIANE EL HASSANI
KRKhouloud Rouzi
Khouloud Rouzi
HAHamza ASSILA
Hamza ASSILA
KKKhalid Karrouchi
Khalid Karrouchi
MAM’hammed Ansar
M’hammed Ansar
Pyrazole, characterized by a five-membered heterocyclic structure featuring two neighboring nitrogen atoms, serves as a core element. Pyrazoles hold a privileged status as versatile frameworks in various sectors of the chemical industry, including medicine and agriculture. Previous reviews have extensively highlighted the significance of pyrazoles and their diverse biological activities, encompassing roles such as antituberculosis, antimicrobial, antifungal, anti-inflammatory, anticancer, and antidiabetic agents. Consequently, they have garnered substantial interest from researchers. The aim of this review is to offer a comprehensive overview of the published research related to the synthesis of pyrazole derivatives, encompassing a discussion of diverse methods for accessing the pyrazole moiety. These methods span from utilizing transition-metal catalysts and photoredox reactions to employing one-pot multicomponent processes, novel reactants, and innovative reaction types. It encompasses studies conducted by numerous scientists worldwide, showcasing collective efforts in advancing the methodologies and applications of pyrazole derivatives.

24 October 2024 in Organics
Verified
Journal Article
Open access
PDF file
IHIssam AMEZIANE EL HASSANI
Issam AMEZIANE EL HASSANI
KRKhouloud Rouzi
Khouloud Rouzi
AHAnouar Ameziane El Hassani
Anouar Ameziane El Hassani
KKKhalid Karrouchi
Khalid Karrouchi
MAM’hammed Ansar
M’hammed Ansar
The triazole scaffold is a crucial component of heterocyclic chemistry, serving as a basic building block in organic synthesis, materials science, and medicinal chemistry. Triazole is a five-membered ring composed of three nitrogen atoms and two carbon atoms, and it exists in two isomeric forms: 1,2,3-triazole and 1,2,4-triazole. Compounds featuring the triazole ring are important heterocycles known for their diverse biological activities, including antimicrobial, antiproliferative, antimalarial, anticonvulsant, anti-inflammatory, antineoplastic, antiviral, analgesic, and anticancer properties. As a result, triazole derivatives have attracted significant attention from researchers. This review aims to provide a thorough overview of the published studies on the synthesis of triazole derivatives, highlighting various methods for obtaining the triazole moiety. These methods include classical approaches as well as microwave and ultrasound-assisted techniques.