Background/Objective: The rising global incidence of skin cancer emphasizes the urgent need for reliable and accurate diagnostic tools to aid early intervention. This study introduces YOLOSAMIC (YOLO and SAM in Cancer Imaging), a fully automated segmentation framework that integrates YOLOv8 for lesion detection, and the Segment Anything Model (SAM)-Box for precise segmentation. The objective is to develop a reliable segmentation system that handles complex skin lesion characteristics without requiring manual intervention. Methods: A hybrid database comprising 3463 public and 765 private dermoscopy images was built to enhance model generalizability. YOLOv8 was employed to localize lesions through bounding box detection, while SAM-Box refined the segmentation process. The model was trained and evaluated under four scenarios to assess its robustness. Additionally, an ablation study examined the impact of grayscale conversion, image blur, and model pruning on segmentation performance. Results: YOLOSAMIC demonstrated high segmentation accuracy, achieving Dice and Jaccard scores of 0.9399 and 0.9112 on the public database and 0.8990 and 0.8445 on the hybrid dataset. Conclusions: The proposed YOLOSAMIC framework provides a robust, fully automated solution for skin lesion segmentation, eliminating the need for manual annotation. Integrating YOLOv8 and SAM-Box enhances segmentation precision, making it a valuable decision-support tool for dermatologists.