Nitrogen is an essential nutrient for plants life cycle. However, the excessive use of this element causes serious problems in agriculture. This can disrupt the development of many important plants.Sesamum indicumor sesame represents one of the most economically important and ancient oil crops in the world. In fact, its seeds are used for many biological activities. The aim of the present study is to evaluate the effect of high levels of nitrogen on some primary and secondary metabolites and the antioxidant activity under different levels of N supply. Results analysis of our investigation showed that the excessive nitrogen supply had a serious effect on the quality of sesame seeds. In fact, N fertilizer promoted the accumulation of proteins until 57.16%, in detriment of oil and sugars that decreased with 49.43% and 16.27%, respectively. Also, total phenolic, flavonoids content, and antioxidant activity showed a significant decrease.

Chronic Kidney Disease of Unknown Etiology (CKDu) is a worldwide hidden health threat that is associated with progressive loss of kidney functions without showing any initial symptoms until reaching end-stage renal failure, eventually leading to death. It is a growing health problem in Asia, Central America, Africa, and the Middle East, with identified hotspots. CKDu disease mainly affects young men in rural farming communities, while its etiology is not related to hypertension, kidney stones, diabetes, or other known causes. The main suspected causal factors are heat-stress, dehydration, exposure to agrochemicals, heavy metals and use of hard water, infections, mycotoxins, nephrotoxic agents, altitude, and genetic factors. This review gives an overview of CKDu and sheds light on its medical history, geographic distribution, and worldwide prevalence. It also summarizes the suspected causal factors, their proposed mechanisms of action, as well as the main methods used in the CKDu prior detection and surveillance. In addition, mitigation measures to reduce the burden of CKDu are also discussed. Further investigation utilizing more robust study designs would provide a better understanding of the risk factors linked to CKDu and their comparison between affected regions.

This work aims to evaluate the polyphenol and flavonoid composition, antioxidant and antibacterial activity of leaf, fruit and pulp extracts of Chamaerops humilis L. Dry extracts of leaves, fruits and pulp were prepared by ultrasonic extraction and examined as potential sources of phenolic...

Experimental studies have shown that various pesticides can damage kidney function, but epidemiological information on the effects of long-term low-level pesticide exposure is lacking. A study in Fez Meknes, Morocco, examined the link between 31 pesticides and end-stage renal disease (ESRD). This study involved 12 hemodialysis centers in various areas. Duration and frequency of use determined lifetime pesticide use, which was adjusted by an intensity factor to account for differences in pesticide application practices. The STROBE guideline was applied in the present work. Multivariate logistic regression was used to assess the correlations between end-stage renal disease, and the ordinal categories of lifetime pesticide use, weighted by intensity, for 31 pesticides. The study included 82 cases and 161 controls, and exposure to Glyphosate, paraquat, 2-4 D, 2-4 D+2-4 MCPA, azoxystrobin and difenoconazole demonstrated positive exposure-response trends. End-stage renal disease was significantly associated with the intensity-weighted exposure to the herbicides 2,4 D (OR = 1.005, CI: 1.003-1.007, p < 0.0001) and 2,4 D + 2,4 MCPA (OR = 1.009, CI: 1.004-1.013, p < 0.0001), and the fungicide difenoconazole (OR = 1.017, CI: 1.001-1.033, p = 0.033). These findings suggest a potential link between exposure to these pesticides and ESRD, warranting further investigation into the underlying mechanisms and the generalizability of these results to other rural populations.

The present study has been undertaken in order to highlight the healing effect of Zizyphus lotus vegetable oil. The seeds of this plant contain an oil rate of 30. The obtained results on the main elements composing the vegetable oil have shown that Zizyphus lotus vegetable oil has a low value of acidity index and it presents a not negligible degree of unsaturation. The value of the peroxide index of Zizyphus lotus vegetable oil is less than 10 which characterizes the most of conventional oils. Furthermore, the spectral analysis by gas chromatography has shown the presence of 53 majority and minority molecules. Thus, the evaluation of the healing activity of Z. lotus seed vegetable oil has demonstrated a highly significant effect against the negative control and silver sulfadiazine was used as conventional treatment for burns. Based on the obtained results, we can suggest that the oil extracted from the seeds of the studied plant could be used to cure wounds.