Altered tryptophan metabolism and indoleamine 2,3-dioxygenase activity are linked to cancer development and progression. In addition, these biological factors have been associated with the development and severity of neuropsychiatric syndromes, including major depressive disorder. However, this biological mechanism associated with both poor disease outcomes and adverse neuropsychiatric symptoms has received little attention in women with breast cancer. Therefore, a pilot study was undertaken to compare levels of tryptophan and other proteins involved in tryptophan degradation in women with breast cancer to women without cancer, and secondarily, to examine levels in women with breast caner over the course of chemotherapy.

The United States Air Force currently relies on schedule-based inspections using nondestructive evaluation methods for ensuring airframe integrity. The sensitivity of a nondestructive evaluation method is quantified statistically using a probability of detection process. The purpose of the probability of detection process is to generate a $a_{90|95}$ metric for a given nondestructive evaluation technique and corresponding defect (e.g. crack). This process could be conducted under various inspection conditions and defect sizes. The set of factors varied in the process is controlled to allow each nondestructive evaluation inspection to be treated as statistically independent. Current United States Air Force structural inspections are performed at time intervals that adhere to the independence assumption. However, the United States Air Force plans to service airframes based on their actual condition instead of the current schedule-based approach. Accordingly, there is emphasis on developing advanced health management technologies, such as structural health monitoring systems, which provide an automated and real-time assessment of a structure’s ability to serve its intended purpose. Therefore, structural health monitoring is considered to be equivalent to an in situ nondestructive evaluation structural inspection device. With a structural health monitoring system, the time interval between inspections will be much smaller than the time intervals between nondestructive evaluation inspections. Since structural health monitoring measurements are from the same sensors, in the same location, the independent measurement assumption used to analyze nondestructive evaluation methods is invalid. In this article, we present a statistical method consistent with current probability of detection process, yet designed to appropriately analyze dependent data. We demonstrate this method first with simulated data and then with experimental data from three test specimens of a representative aircraft structural component. This method leverages the advantages of a structural health monitoring system through its frequent measurements while maintaining its usefulness through appropriately computed probability of detection values. Furthermore, we present a numerical method for estimating the number of test specimens needed to achieve a desired $a_{90|95}$ value.

Internalizing symptoms are prevalent in students as they enter and complete college. Considering research suggesting mental health benefits of pet ownership, this study explores the relationship between pet ownership, social support (SS), and internalizing symptoms (IS) in a cohort of students across their 4-year college experience. With no differences at college entry, students growing up with pets had greater IS through the fourth year, and greater SS through the third year, than those without pets. Currently living with a pet, gender, SS and personality predicted IS in the fourth year. Females experiencing higher IS in their first year are more likely to live with pets in their fourth year, and fourth year females living with pets or greatly missing absent pets have higher IS than females without pets or missing pets less. Findings suggest a unique relationship between IS in female students and their pet relationships not seen in males.

The validation of structural health monitoring (SHM) systems for aircraft is complicated by the extent and number of factors that the SHM system must demonstrate for robust performance. Therefore, a time- and cost-efficient method for examining all of the sensitive factors must be conducted. In this paper, we demonstrate the utility of using the simulation modeling environment to determine the SHM sensitive factors that must be considered for subsequent experiments, in order to enable the SHM validation. We demonstrate this concept by examining the effect of SHM system configuration and flaw characteristics on the response of a signal from a known piezoelectric wafer active sensor (PWAS) in an aluminum plate, using simulation models of a particular hot spot. We derive the signal responses mathematically and through the statistical design of experiments, we determine the significant factors that affect the damage indices that are computed from the signal, using only half the number of runs that are normally required. We determine that the transmitter angle is the largest source of variation for the damage indices that are considered, followed by signal frequency and transmitter distance to the hot spot. These results demonstrate that the use of efficient statistical design and simulation may enable a cost- and time-efficient sequential approach to quantifying sensitive SHM factors and system validation.