Background: Suicidal behavior presents a significant dilemma in the context of Alzheimer’s disease. Numerous ethical discussions have emerged regarding euthanasia for patients suffering from neurodegenerative conditions, and research indicates an elevated incidence of suicide in the early stages of dementia. However, there remains a gap in knowledge concerning the historical prevalence of suicidal ideations or attempts among individuals diagnosed with Alzheimer’s disease. This study aims to investigate the historical patterns of suicidal behavior and the associated factors across the lifespan in patients with Alzheimer’s disease. Methods: This study is an excerpt from a case–control research study, where the sample size was calculated at 150 participants, with 75 in the case group and 75 in the control group. Here, the descriptive statistics for the first third of the sample, 50 participants, are discussed. Results: Among the participants in the case group, 12.5% reported having suicidal ideation throughout life, compared to 24% in the control group (OR for suicidal ideation = 0.432 [0.095–1.966]). Additionally, among the participants in the case group, 4% reported having attempted suicide at some point in their life, compared to 8% in the control group (OR for suicide attempts = 0.479 [0.41–5.652]). People with Alzheimer’s disease tended to have a worse quality of life but less suicidality. Conclusions: It appears that suicidal behavior is inversely related to the risk of developing suicidal intentions. The odds ratio data demonstrate the need for a larger sample size to determine whether there is a difference in the history of suicide throughout the lives of people with Alzheimer’s disease and among the general population.

Background: There have been reports of numerous risk factors for Alzheimer's disease. Although widely investigated, some points during the evolution of the disease have been obscure. One of them is a great frustration with therapeutic expectations. Why has there been an increase in suicidal behavior in treatments with anti-beta-amyloid drugs? Interpersonal stress is one of the factors that may be connecting Alzheimer's disease to suicide. Method: To observe possible associations between Alzheimer's disease and suicide, two validated questionnaires were selected. We recruited 20 elderly patients over 65 years old to observe the feasibility of further research using these instruments. The study was considered viable if all participants showed no difficulty in understanding the questions and completed both questionnaires in less than 30 minutes with a tendency to homogeneity. A description of the statistical data obtained was made. Results: All participants adequately understood the questions and completed the questionnaires in less than 30 minutes. In 10% of the sample, suicide attempts occurred throughout their lives. The average age of respondents was 75 years old. The QoSL Pareto diagram demonstrated a large concentration. The data demonstrated homogeneity. Conclusions: The application of the questionnaires in a sample suitable for carrying out analytical statistics was demonstrated. We have two great tools to try to understand the possible association between Alzheimer's disease and suicide.

Contrary to what has been happening in most countries in the world, suicide mortality in Brazil has been increasing since 2016. To identify the epidemiological profile that may be associated with this increase in suicidal behavior in the population, we looked for a city with low rates of suicide mortality until 2016 and in which had a detectable growing epidemic wave in recent years to better elucidate the issue. This study aims to identify factors associated with suicidal ideation, suicidal planning, suicide attempts, and suicide.A validated questionnaire was used - Kaiser-Meyer-Olkin index (KMO) = .86 (acceptable greater than .7) and intraclass correlated coefficient (ICC) = .98 (acceptable greater than .9). Data collected was obtained by sampling for the convenience of the online questionnaire with a minimum sample of 400 respondents. The general population of Marília’s city, a medium-sized city in São Paulo state of Brazil, voluntarily responded to the questionnaire. Prevalence data was described in ratios and incidence was described in tables. The association was measured by factor analysis. The state government's data information platform (DataSUS) was consulted to verify the incidence of suicides from 2016 to 2023. The prevalence ratio of suicide attempts in people with mental disorders was 8.09%. There was a 600% increase in the incidence of suicide from 2016 to 2023 among young adults. Interpersonal problems were highly prevalent in people with suicidal ideation, suicidal planning, and suicide attempts. Heroism appears to be a suicidal equivalent and may be associated with most young deaths. Heroic behavior demonstrated a prevalence of 66.1% for committing tragic suicide. We get c² of 31.4 for 18 degrees of freedom (p=0.026) of 10 representative variables in factor analysis with eight of the 10 variables demonstrating an association for one component. The young population has demonstrated epidemically growing suicide rates. Social segregation can affect young people's social lives and increase suicidal behavior.

Ao longo dos últimos anos, temos observado um processo de transição demográfica, que tem evidenciado o aumento do número de idosos e a diminuição do número da população jovem. Tal transição demográfica vem acompanhada de uma transição epidemiológica, caracterizada por uma mudança no perfil de morbimortalidade, com a prevalência aumentada de doenças crônico-degenerativas, como as síndromes demenciais. O acometimento das habilidades cognitivas pode representar um impacto importante na autonomia e independência das pessoas idosas, podendo culminar em processos demenciais. Neste contexto, torna-se importante o desenvolvimento de estudos que objetivem desenvolver estratégias que favoreçam a saúde cognitiva dos idosos. Neste sentido, o objetivo deste trabalho foi avaliar como a prática de atividades físicas pode contribuir na saúde cognitiva da população idosa. Este trabalho foi constituído por uma revisão sistemática a partir da plataforma PubMed, com os descritores “sports and cognition and elderly”. A amostra final que constituiu este estudo foi composta por 11 artigos. A prática de atividades físicas diversificadas apresenta uma associação com a melhora no desempenho cognitivo em idosos saudáveis. Todavia, não há uma definição sobre qual tipo de atividade física contribui mais para o desempenho cognitivo ou qual a frequência e intensidade necessárias para que haja ganho nas habilidades cognitivas de pessoas idosas.

Objectives: The tau protein is essential for stabilizing microtubules. Changes in its phosphorylation are identified in many neurodegenerative diseases, such as frontotemporal dementia and Alzheimer's disease. The hyperphosphorylation of the tau protein is linked to various factors, including stress, which has a substantial impact on depressive illness. The present study aimed to systematically review studies that describe the association between tau protein and depression.Design: The present study used the PRISMA statement 2020 as the inclusion criterion for articles describing tau protein in individuals with depression. The exclusion criterion was the lack of comparison of tau protein levels with individuals without depression.Results: A total of 138 papers were identified, of which 21 were ultimately included. One out of every three articles included demonstrated the statistical significance of the tau protein values between the depression group and controls. Only one had an adequate sample but demonstrated results without any major significance.Conclusions: The association between tau protein and depression remains unclear. Studies with adequate sampling are necessary to answer this question.

Background: Suicidal behavior presents a significant dilemma in the context of Alzheimer's disease. Numerous ethical discussions have emerged regarding euthanasia for patients suffering from neurodegenerative conditions, and research indicates an elevated incidence of suicide in the early stages of dementia. However, there remains a gap in knowledge concerning the historical prevalence of suicidal ideations or attempts among individuals diagnosed with Alzheimer's disease. This study aims to investigate the historical patterns of suicidal behavior and the associated factors across the lifespan in patients with Alzheimer's disease. Methods: This study is an excerpt from case-control research, where the sample was calculated at 150 participants, 75 for the case group and 75 for the control group. Here, the descriptive statistics of the first third of the sample, 50 participants, were made. Results: 12,5% of cases participants had suicidal ideation throughout life and 24% of the control group (OR for suicidal ideation = 0.432 [0.095-1.966]). 4% of cases participants attempted suicide throughout life and 8% of the control group (OR for suicide attempts = 0.479 [0.41-5.652]). Persons with Alzheimer's disease were associated with a worse quality of life and tended to have less suicidality. Conclusions: It appears that suicidal behavior is inversely related to the risk of developing suicide. The odds ratio data demonstrate the need for a larger sample size to determine whether there is a difference in the history of suicide throughout the lives of people with Alzheimer's disease and the general population.