An efficient, environmentally benign isocyanide-based domino protocol is presented for synthesizing spiroheterocycles with 2-amino benzothiazole/1,3,4-thiadiazole, cyclohexyl/tert-butyl isocyanides and isatines/cyclic carbonyls, catalyzed by recyclable nanocrystalline TiO2.
13 July 2016 in Journal of Applied Polymer Science
An efficient and environmentally sustainable domino protocol has been presented for the synthesis of structurally diverse spiroannulated pyrimidophenazines using erbium doped TiO 2 nanoparticles as a recyclable and reusable heterogeneous acid catalyst.