Caroline de Farias Charamba Leal

Ms. Caroline de Farias Charamba Leal


Research Focus & Metrics

Academic Career Length

3Years (2024-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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30 July 2024 in Polymers
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Journal Article
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CLCaroline de Farias Charamba Leal
Caroline de Farias Charamba Leal
SMSamille Biasi Miranda
Samille Biasi Miranda
ENEverardo Lucena de Alves Neto
Everardo Lucena de Alves Neto
KFKeitry Freitas
Keitry Freitas
WSWesley Viana de Sousa
Wesley Viana de Sousa
Marcos Antonio Japiassú R. MontesMarcos Antonio Japiassú R. Montes
Marcos Antonio Japiassú R. Montes
The objective was to compare the color match and color stability behavior of single- and multi-shade resin-based composites (RBCs) used for direct restorations. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Randomized clinical trials evaluating the shade performance of single-shade RBCs in direct restorations were included. A search of the scientific literature was performed in five databases (April 2024). The meta-analysis was performed using RevMan 5.4, calculating the risk difference (RD) and 95% confidence interval (CI) of the dichotomous outcome using a random effects model. Bias was assessed using the RoB 2.0 tool, and certainty of evidence was assessed using the GRADEpro tool. Four studies were selected, with 263 restorations analyzed. The results showed comparable performance between single-shade RBCs and multi-shade RBCs in terms of color match and color stability over 12 months. Three studies had a low risk of bias with all expected results, and one study had some concerns. The certainty of evidence for color stability was considered low for all follow-up periods due to the small number of events and sample size. According to the United States Public Health Service Evaluation (USPHS) and the World Dental Federation (FDI), there is comparable clinical color performance between single-shade and multi-shade RBCs over 12 months.

Verified
Journal Article
Open access
PDF file
SMSamille Biasi Miranda
Samille Biasi Miranda
CLCaroline de Farias Charamba Leal
Caroline de Farias Charamba Leal
Rodrigo LinsRodrigo Lins
Rodrigo Lins
Marcos Antonio Japiassú R. MontesMarcos Antonio Japiassú R. Montes
Marcos Antonio Japiassú R. Montes
Background: Tooth bleaching can compromise the color match between dental tissues and restorations. Single-shade resin-based composites (RBCs) have been developed to simplify shade matching; however, their performance after dental bleaching remains uncertain. Objectives: This study aimed to evaluate the ability of single-shade RBCs to adapt to the color of the dental substrate after dental bleaching. Methods: A systematic review was conducted according to the PRISMA guidelines and registered in PROSPERO. Searches were performed in PubMed, Embase, Web of Science, and Scopus (December 2024). In vitro studies were selected based on the PICOS criteria (P: human or bovine teeth; I: teeth restored with single-shade RBCs and bleached; C: bleached dental tissue; O: color match; S: in vitro studies). Two reviewers (kappa = 0.90) applied eligibility criteria, extracted the data, and assessed the risk of bias using the RoBDEMAT tool. Results: Eight studies involving 362 restorations were included. Most studies indicated that single-shade RBCs achieved an acceptable color match after tooth bleaching. Study quality was generally moderate to low, with most evaluations rated as “sufficiently reported or adequate”. Conclusions: Single-shade RBCs demonstrated the ability to match bleached dental tissue in vitro, although effectiveness may vary depending on bleaching duration and storage conditions.

10 September 2024 in Polymers
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Journal Article
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CLCaroline de Farias Charamba Leal
Caroline de Farias Charamba Leal
BVBeatriz Barros Viana
Beatriz Barros Viana
SMSamille Biasi Miranda
Samille Biasi Miranda
RLRenally Bezerra Wanderley e Lima
Renally Bezerra Wanderley e Lima
CSCleyton Cézar Souto Silva
Cleyton Cézar Souto Silva
Marcos Antonio Japiassú R. MontesMarcos Antonio Japiassú R. Montes
Marcos Antonio Japiassú R. Montes
This in vitro study aimed to analyze the surface roughness (Ra) and color stability (ΔEab, ΔE00) following simulated mechanical brushing and to evaluate the microtensile (μTBS) of self-adhering resin flowable (SARF) to dentin. The selected materials were Constic, Yflow AS, and Tetric N flow (TNF/control). Thirty composite resin cylinders were fabricated for surface property evaluation. Ra and color were assessed both before and after simulated brushing. The thresholds of 50:50% perceptibility and acceptability of color differences in the evaluated resins were assessed. For μTBS analysis, fifteen molars were selected, sectioned to expose flat dentin surfaces, and restored according to the manufacturers’ instructions for microtensile testing. There were statistically significant differences in Ra among the groups, with Constic exhibiting the highest Ra value (0.702 µm; p < 0.05), whereas Yflow AS presented the lowest Ra value (0.184 µm). No statistically significant difference in color was observed among the groups (p > 0.05). The 50:50% perceptibility and acceptability thresholds were set at 1.2 and 2.7 for ΔEab and 0.8 and 1.8 for ΔE 00. All the results fell within the acceptable limits. The mean μTBS values of Constic, Yflow AS, and TNF were 10.649 MPa, 8.170 MPa, and 33.669 MPa, respectively. This study revealed increased Ra and comparable color stability among all the tested composite resins after abrasion. However, the SARF exhibited lower μTBS compared to conventional using an adhesive system.

19 August 2025 in Journal of Clinical Medicine
Verified
Journal Article
Open access
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SMSamille Biasi Miranda
Samille Biasi Miranda
CLCaroline de Farias Charamba Leal
Caroline de Farias Charamba Leal
GMGiovana Lordsleem de Mendonça
Giovana Lordsleem de Mendonça
RLRenally Bezerra Wanderley e Lima
Renally Bezerra Wanderley e Lima
AAAna Karina Maciel de Andrade
Ana Karina Maciel de Andrade
Marcos Antonio Japiassú R. MontesMarcos Antonio Japiassú R. Montes
Marcos Antonio Japiassú R. Montes
Background/Objectives: Self-adhesive flowable resins (SAFR) entered the market, eliminating the adhesive system application due to their self-adhesive technology. Guided by the PICO framework (Population, Intervention, Comparison, Outcome), the aim was to conduct a systematic review of clinical studies to compare the clinical performance of Self Adhesive Flowable Resin (SAFRs) with conventional flowable resins used for direct restorations. Methods: The protocol of this systematic review was registered in the International Prospective Register of Systematic Reviews (CRD42023394297) and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. Five databases (PubMed, Embase, Web of Science, Scopus, and Cochrane Library) were searched from inception to July 2025. Nine randomized clinical trials were included, totaling 493 restorations in 232 patients. Clinical performance was assessed using USPHS or FDI criteria, with follow-up periods ranging from 6 months to 5 years. Data were pooled using a random-effects meta-analysis to calculate risk differences (RD) and 95% confidence intervals (CI) for marginal adaptation, retention, marginal staining, post-operative sensitivity, color stability, surface roughness, secondary caries, and anatomical form. Results: Meta-analysis showed no significant differences between SAFRs and CFRCs for in terms of: marginal adaptation (RD = 0.01; 95% CI: −0.02 to 0.04; p = 0.53; I2 = 0%), retention (RD = 0.00; 95% CI: −0.02 to 0.03; p = 0.81; I2 = 0%), marginal staining (RD = 0.01; 95% CI: −0.01 to 0.02; p = 0.51; I2 = 0%), and post-operative sensitivity (RD = −0.01; 95% CI: −0.03 to 0.02; p = 0.62; I2 = 0%). The certainty of the evidence for all outcomes was rated as moderate to high according to the GRADE assessment. Conclusions: SAFR restorations demonstrated comparable clinical performance to conventional resins; however, heterogeneity in follow-up duration and the scarcity of long-term data (>5 years) warrant caution.

14 June 2024 in Preprints.org
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Preprint
Open access
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CLCaroline de Farias Charamba Leal
Caroline de Farias Charamba Leal
SMSamille Biasi Miranda
Samille Biasi Miranda
EMEverardo Lucena de Alves Melo
Everardo Lucena de Alves Melo
KFKeitry Freitas
Keitry Freitas
WSWesley Viana de Sousa
Wesley Viana de Sousa
Marcos Antonio Japiassú R. MontesMarcos Antonio Japiassú R. Montes
Marcos Antonio Japiassú R. Montes
The objective was to compare the color match and color stability behavior of single and multishade resin-based composites (RBCs) used for direct restorations. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Randomized clinical trials evaluating the shade performance of single-shade RBCs in direct restorations were included. A search of the scientific literature was performed in 5 databases (April 2024). The meta-analysis was performed using RevMan 5.4, calculating the risk difference (RD) and 95% confidence interval (CI) of the dichotomous outcome using a random effects model. Bias was assessed using the RoB 2.0 tool, and certainty of evidence was assessed using the GRADE tool. Four studies with 263 restorations analyzed were selected. The results showed comparable performance between single-shade RBCs and multishade RBCs in terms of color match and color stability over 12 months. Three studies had a low risk of bias with all expected results, and one study had some concerns. The certainty of evidence for color stability was considered low for all follow-up periods due to the small number of events and sample size. According to the United States Public Health Service Evaluation (USPHS) and the World Dental Federation (FDI), there is comparable clinical color performance between single-shade and multishade RBCs over 12 months.

6 February 2026 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
SMSamille Biasi Miranda
Samille Biasi Miranda
Rodrigo LinsRodrigo Lins
Rodrigo Lins
JSJulia Almeida Maciel da Silveira
Julia Almeida Maciel da Silveira
CLCaroline de Farias Charamba Leal
Caroline de Farias Charamba Leal
CMCaroline Mathias
Caroline Mathias
Marcos Antonio Japiassú R. MontesMarcos Antonio Japiassú R. Montes
Marcos Antonio Japiassú R. Montes
Objectives: To evaluate the efficacy of resin infiltrants (RIs) in controlling non-cavitated occlusal carious lesions (NCOCLs) in primary and permanent teeth. Methods: This systematic review followed PRISMA guidelines. Randomized clinical trials (RCTs) and in vitro/ex vivo studies comparing RI with placebo or other materials were included. Searches were conducted in five databases and gray literature up to December 2025. Risk of bias was assessed using the RoB 2.0 tool for RCT and an adapted instrument for in vitro/ex vivo studies. Certainty of evidence was evaluated using the GRADE tool, and data were synthesized qualitatively. Results: Eight studies were included, of which only two were RCTs, and six were in vitro and ex vivo studies. RCTs showed reduced caries progression in infiltrant-treated groups compared with controls, with efficacy comparable to conventional sealants. In vitro studies demonstrated improved resin penetration and sealing ability with optimized protocols. Risk of bias ranged from low to moderate. Certainty of clinical evidence was low, primarily due to the limited number of RCTs and methodological limitations. Conclusions: RIs may be effective in managing NCOCLs, with performance comparable to conventional preventive approaches. However, the limited number of clinical trials and short follow-up periods reduce the strength of the evidence. Long-term clinical studies are needed to confirm the sustained effectiveness and durability of RIs.