Recent worldwide outbreak of SARS-COV-2 pandemic has increased the thirst to discover and introduce antiviral drugs to combat it. The bioactive compounds from plant sources, especially terpenoid have protease inhibition activities so these may be much effective for the control of viral epidemics and may reduce the burden on health care system worldwide. Present study aims the use of terpenoid from selected plant source through bioinformatics tools for the inhibition of SARS-COV-2. This study is based on descriptive analysis. The Protein Data Bank and PubChem database were used for the analysis of SARS-COV-2 protease and plant source terpenoids. Molecular docking by using molegro virtual docker (MVD) software was carried out. The findings of study are based on the inhibitory actions of different plant sourced terpenoid against SARS-COV-2. As per the available resources and complementary analysis these phytochemicals have capacity to inhibit 3CL^pro protease. The study reports that (3,3-dimethylally) isoflavone (Glycine max), licoleafol (Glycyrrhiza uralensis), myricitrin (Myrica cerifera), thymoquinone (Nigella sativa), bilobalide, ginkgolide A (Ginkgo biloba), Salvinorin A (Salvia divinorum), citral (Backhousia citriodora) and prephenazine (drug) showed high activity against SARS-COV-2 protease 3CL^pro. The drug like and ADMET properties revealed that these compounds can safely be used as drugs. Cross structural analysis by using bioinformatics study concludes that these plant source terpenoid compounds can be effectively used as antiprotease drugs for SARS-COV-2 in future.

A novel wood rotting species of genus Vanderbylia occurring at the base of Zanthoxylum armatum is described from mixed vegetation of District Bhimber, Azad Jammu & Kashmir, based on phylogenetic analyses of ITS and LSU sequences. Further, distinct morpho-anatomical characters confirmed the novelty of the species as Vanderbylia kashmiriana. The taxon is characterized by pileate and corky basidiomata, a dimitic hyphal system with peculiar, extensively branched arboriform hyphae, globose to sub-globose to ellipsoid, hyaline, apiculate, strongly dextrinoid basidiospores, sub-clavate to obovoid basidia with the variable number of sterigmata (1–4), clavate to obclavate to ventricose to tubular, apically encrusted, granular, clamped cystidia. This is the first described species of the genus Vanderbylia from Pakistan.