A senescence-associated secretory phenotype (SASP) and a mild inflammatory response characteristic of senescent cells (inflammaging) form the conditions for the development of cardiovascular diseases: atherosclerosis, coronary heart disease, and myocardial infarction. The purpose of the review is to analyze the pool of signaling molecules that form SASP and inflammaging in cells of the cardiovascular system and to search for targets for the action of vasoprotective peptides. The SASP of cells of the cardiovascular system is characterized by a change in the synthesis of anti-proliferative proteins (p16, p19, p21, p38, p53), cytokines characteristic of inflammaging (IL-1α,β, IL-4, IL-6, IL-8, IL-18, TNFα, TGFβ1, NF-κB, MCP), matrix metalloproteinases, adhesion molecules, and sirtuins. It has been established that peptides are physiological regulators of body functions. Vasoprotective polypeptides (liraglutide, atrial natriuretic peptide, mimetics of relaxin, Ucn1, and adropin), KED tripeptide, and AEDR tetrapeptide regulate the synthesis of molecules involved in inflammaging and SASP-forming cells of the cardiovascular system. This indicates the prospects for the development of drugs based on peptides for the treatment of age-associated cardiovascular pathology.

This article presents data on primary disability at working and retirement ages obtained from a survey of citizens by the General Bureau of Medical and Social Expertise of St. Petersburg during the...

Верификация диагноза ревматической полимиалгии на приеме терапевта, врача общей практики или гериатра представляет значительные трудности из-за отсутствия патогномоничных признаков заболевания. Визитной карточкой заболевания является сочетание выраженных болей в проксимальных группах мышц в сочетании с высоким острофазовым воспалительным ответом. Verification of the diagnosis of rheumatic polymyalgia at the reception of a general practitioner, geriatrician presents significant difficulties due to the lack of pathognomonic signs of the disease. The «calling card» of the disease is a combination of severe pain in the proximal muscle groups in combination with a high acute inflammatory response.

Проведена оценка барьеров у лиц старше трудоспособного возраста с нарушением зрительных функций с использованием Международной классификации функционирования, ограничений жизнедеятельности и здоровья (МКФ) для обоснования перечня необходимых вспомогательных услуг. Повышение числа лиц старших возрастных групп объективно ведет к увеличению числа граждан, испытывающих трудности с решением медицинских, социальных и психологических проблем. Анализ полученных результатов исследования показал, что значительная часть лиц вследствие нарушения зрительных функций испытывают ограничения и барьеры в физическом окружении, эмоциональной сфере, во взаимоотношениях в семье с близкими и дальними родственниками. При оценке барьеров окружающей среды, мешающих полноценной жизнедеятельности лиц с нарушениями зрительных функций, выявлено наличие ограничений в разделах D4 «Мобильность», D5 «Самообслуживание», D6 «Бытовая жизнь». Наличие барьеров и ограничений свидетельствует о необходимости осуществления мер социальной защиты, включая реабилитацию, потребности корректировки перечня вспомогательных услуг. Использование МКФ позволит определить те барьеры, с которыми сталкивается инвалид вследствие нарушения зрительных функций в различных сферах жизнедеятельности, и адресно оказать поддержку и помощь, обеспечить объективность и достаточность мер социальной защиты для каждого инвалида на научной основе. The assessment of barriers in persons older than working age with visual impairment was carried out using the International Classification of Functioning, Disabilities and Health to substantiate the list of necessary support services. An increase in the absolute number of people in older age groups objectively leads to an increase in the number of citizens experiencing difficulties in solving medical, social and psychological problems. Analysis of the results of the study showed that a significant part of people, due to impaired visual functions, experience limitations and barriers in physical environment, emotional sphere, family relationships with close and distant relatives. When assessing environmental barriers that interfere with the full-fledged life of persons with visual impairments, the presence of restrictions in sections D4 «Mobility», D5 «Self-service», D6 «Household life» was revealed. The presence of barriers and restrictions indicates the need to implement social protection measures, including rehabilitation, the need to adjust the list of support services. The use of the International Classification of Functioning, Disability and Health will determine the barriers faced by a disabled person due to visual impairment in various spheres of life and provide targeted assistance, support and assistance, to ensure the objectivity and sufficiency of social protection measures for each disabled person, on a scientific basis.

The majority of patients with amputation defect of the lower extremities are elderly citizens with high co- and polymorbidity, the presence of several geriatric syndromes, which adversely affects the prognosis, reduces the rehabilitation potential, in some cases leads to the development of cardiovascular complications, amputation of the second limb, severe disability and high postoperative mortality. The key link in the rehabilitation process of disabled people with a lower limb stump is to provide them with a functional prosthesis. The article provides an analysis of morbidity, primary disability in the period from 2015 to 2019, gender, age and clinical characteristics of patients living in St. Petersburg who underwent amputation of the lower limb due to obliterating artery diseases is presented. It was found that there is no information on the survival rate of patients after amputation at various times of the post-hospital period in St. Petersburg. We have identified a pronounced imbalance between the number of lower limb amputations performed and the number of applications of disabled people to the bureau of medical and social expertise for providing technical means of rehabilitation and referral to primary prosthetics.