Alpsoy E, et al. Ann Dermatol. 2020 Jun;32(3):181-188. https://doi.org/10.5021/ad.2020.32.3.181

BACKGROUND:I meticulously inspected trunks of 488 patients aged 40 years or older who had at least 1 truncal cherry angioma. MATERIAL AND METHODS:The median number of truncal cherry angiomas was 4. Their median size was 3 millimeters. A pale halo aro...

Background: The frequencies of comorbidities in patients with psoriasis have been compared to that in the general population in many studies. Moreover, several studies have investigated the risk factors influencing the number of comorbidities in patients with psoriasis. However, a few studies have examined clusters of patients with psoriasis according to their comorbidities. In this study, we aimed to explore the multicomorbidities of psoriasis vulgaris in terms of risk factors and clusters. Methods: All diagnoses of 452 patients with psoriasis vulgaris were extracted from electronic medical records of a tertiary hospital. Binary association coefficients were calculated for all pairs of comorbidities. Subsequently, a hierarchical cluster analysis was performed. Results: Among the patients, 30.5% had no comorbidities, 28.8% had a single comorbidity, and 40.7% had multiple comorbidities. The number of comorbidities was positively associated with age and follow-up duration but not with sex. The most striking cluster of comorbidities was composed of diabetes, hepatosteatosis, hyperlipidemia, hypertension, cancer, and cardiovascular disease. Conclusion: This cluster could be explained by cardiometabolic multimorbidity. Exploring such clusters may provide a more forward-looking perspective for the management of psoriasis patients.

Amaç: Herpetik infeksiyonların tanısında Tzanck yayması için en uygun lezyonların 1-3 günlük olduğu bildirilmiştir. Bu çalışmada, daha uzun süreli lezyonlardan yayma yapmanın ek yarar sağlayıp sağlamayacağını değerlendirmek amaçlanmıştır.Gereç ve Yöntem: Hasta kayıtları geriye dönük olarak incelendi. Hasta dosyasında "Tzanck" sözcüğü geçen ve bu işlemin herpetik infeksiyon tanısı için yapıldığı hastalar seçildi. Lezyonların kaçıncı gününde yayma yapıldığı belirtilen hastalar çalışmaya dahil edildi. Bulgular: Yüzs eksen hastanın 65'inde bu işlem, herpetik infeksiyon tanısı için yapılmıştı. Ön tanı, hastaların 31 (%47.7)'inde herpes simpleks, 26 (%26.0)'sında herpes zoster ve 8 (%12.3)'inde varisella idi. Kesin tanı ise 16 (%34.8)'sında herpes simpleks, 26 (%56.5)'sında herpes zoster ve 4 (%8.7)'ünde varisella idi. Toplam 33 (10’u herpes simpleks, 20’si herpes zoster ve 3’ü varisella) hastada Tzanck yayma sonucu pozitif olarak kaydedilmişti. Yalnız kesin tanısı da herpetik infeksiyon olan 46 hasta ele alınacak olursa, 1-3 günlük lezyonlarda %75 (15/20), 4-6 günlük lezyonlarda %67 (10/15) ve 7-25 günlük lezyonlarda %73 (8/11) oranında pozitiflik elde edilmişti. Sonuç: Tzanck yaymasında pozitifliğin en çok veziküllerden elde edildiği, ancak püstül ve erozyon gibi öteki lezyonlardan elde edilen pozitifliğin de azımsanamayacağı, üstelik bir vezikülün üç günden uzun sürebileceği görüldü. Bu verilerin ışığında, Tzanck yaymasının daha eski lezyonlarda da yapılmasının tanıya katkı sağlayabileceği gösterilmiştir.

Purpose: This study aimed to identify the clinical and behavioral risk factors associated with secondary bacterial skin infections in children with scabies. Materials and Methods: We retrospectively reviewed records of 200 children (0–18 years) diagnosed with scabies between January 2022 and December 2024. All received a two-dose permethrin regimen and were followed for 30 days. Collected data included age, sex, pruritus severity, symptom-to-diagnosis interval, treatment adherence, and household contact treatment.. Results: Secondary skin infection occurred in 35% of children at a median of 9 days (Interquartile range (IQR) 6–12) after treatment. The median interval from symptom onset to scabies diagnosis was 11 days (IQR 8–15). In bivariate analyses, infected children were younger ( median age 7.5 vs. 8.5 years) and had higher pruritus scores (7.0 vs. 5.0). Multivariable analysis identified five independent predictors. Younger age (adjusted odds ratio (aOR) 0.92 per year; 95% confidence interval (CI) 0.85–0.99), higher pruritus score (aOR 1.18 per point; 95% CI 1.06–1.31), longer symptom-to-diagnosis interval (aOR 1.10 per day; 95% CI 1.02–1.19), incomplete topical application (aOR 2.9; 95% CI 1.3–6.4) and failure to treat household contacts (aOR 3.7; 95% CI 1.6–8.5). Impetigo (48.5%) and cellulitis (24.6%) were the most frequent manifestations. Conclusion: Early diagnosis, complete topical application, household treatment, and monitoring pruritus severity are key to reducing secondary infections in pediatric scabies.