The free-radical-induced syntheses of indolizines were reviewed by type of catalyst.

A highly enantio- and diastereoselective domino thia-Michael/aldol reaction applying 5H-dibenzo[a,c][7]annulen-5-one as a Michael acceptor, catalyzed by a chiral phosphoric acid (CPA), has been developed. The bridged biaryl adduct contains multiple stereogenic centers in the bridging linkage as well as a thermodynamically controlled stereogenic axis. The energy difference between the two atropodiastereomers is about 9.1 kcal mol⁻¹, which accounts for the observed excellent diastereoselectivity (>20 : 1).

The original version of this article unfortunately contained error in Figure 2, 6, 7, 8. During the recent process of organizing samples and data, we discovered that the images of the kidney in CCI + IBU group in Figure 2 have been mistakenly mixed with the images from our previously published research.