Building segmentation has extensive research value and application prospects in high-resolution remote sensing image (HRSI) processing. However, complex architectural contexts, varied building morphologies, and non-building occlusions make building segmentation challenging. Compared with traditional methods, deep learning-based methods present certain advantages in terms of accuracy and intelligence. At present, the most popular option is to first apply a single neural network to encode an HRSI, then perform a decoding process through up-sampling or using a transposed convolution operation, and then finally obtain the segmented building image with the help of a loss function. Although effective, this approach not only tends to lead to a loss of detail information, but also fails to fully utilize the contextual features. As an alternative, we propose a novel network called NPSFF-Net. First, using an improved pseudo-Siamese network composed of ResNet-34 and ResNet-50, two sets of deep semantic features of buildings are extracted with the support of transfer learning, and four encoded features at different scales are obtained after fusion. Then, information from the deepest encoded feature is enriched using a feature enhancement module, and the resolutions are recovered via the operations of skip connections and transposed convolutions. Finally, the discriminative features of buildings are obtained using the designed feature fusion algorithm, and the optimal segmentation model is obtained by fitting a cross-entropy loss function. Our method obtained intersection-over-union values of 89.45% for the Aerial Imagery Dataset, 71.88% for the Massachusetts Buildings Dataset, and 68.72% for the Satellite Dataset I.