Preeklampsia dengan komplikasi merupakan penyakit obstetri dengan prevalensi tertinggi di Indonesia sehingga dapat meningkatkan angka mortalitas dan morbiditas ibu dan bayi. Penyakit ini dikenal sebagai the disease of theorydikarenakan belum terdapatnya teori yang mampu menjelaskan faktor risiko penyakit ini secara jelas. Penelitian ini dilakukan untuk mengetahui prevalensi kejadian preeklampsia dengan komplikasi di RSUP Dr. Mohammad Hoesin periode 1 Januari 2015 - 31 Desember 2017 sekaligus menganalisis faktor risiko yang mempengaruhinya. Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional.Penelitian ini menggunakan data sekunder rekam medik ibu bersalin di RSUP Dr. Mohammad Hoesin Palembang. Sampel penelitian terdiri dari 117 ibu bersalin dengan PDK dan 183 ibu bersalin non-PDK. Data dianalisis menggunakan uji chi-squaredan regresi logistik biner metode Enter pada aplikasi SPSS. Prevalensi kejadian preeklampsia dengan komplikasi di RSUP Dr. Mohammad Hoesin Palembang periode 1 Januari 2015–31 Desember 2017 adalah 14,45%. Hasil analisis bivariat menunjukan usia maternal (p=0,000; PR=2,229; CI 95%: 2,556–7,212), IMT (p=0,000; PR=2,167; CI 95%: 1,525-3,080), riwayat hipertensi dalam kehamilan (p=0,000; PR=3,597; CI 95%: 2.860–4.523), dan jumlah paritas (p=0,007; PR=0,618; risk=1,618; CI 95%: 0.43– 0.883) memiliki hubungan yang signifikan terhadap kejadian preeklampsia dengan komplikasi. Pekerjaan (p=0,065), jarak kehamilan (p=0,458), dan riwayat penyakit maternal (p=0,573) memiliki hubungan yang tidak signifikan terhadap kejadian tersebut. Hasil analisis multivariat menunjukkan usia maternal, pekerjaan, IMT, jarak kehamilan, dan riwayat hipertensi dalam kehamilan memiliki probabilitas sebesar 74,5% terhadap kejadian preeklampsia dengan komplikasi. Prevalensi kejadian preeklampsia dengan komplikasi di RSUP Dr. Mohammad Hoesin masih relatif tinggi, dan faktor risiko yang paling signifikan terhadap kejadian tersebut adalah riwayat hipertensi dalam kehamilan.

Background. Preeclampsia is defined as gestational hypertension and proteinuria which can be measured by the elevation of liver transaminases to twice normal concentration, and the symptoms of increased intracranial pressure such as dizziness, blurred vision, and seizures. Zinc is an essential mineral for many biological functions and one of the trace elements that is directly involved in the oxidative/antioxidant balance, a pathogenesis process in preeclampsia that is highly dependent on dietary habits and supplements. This study was aimed to assess the association between serum zinc level with preeclampsia (PE). Methods: This observational, case-control study was performed on 90 women with singleton pregnancies at 28 to 42 weeks of gestation which were referred to the Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin General Hospital, Palembang, between August 2020 to November 2020. 30 pregnant women with PE were selected as cases and 60 healthy pregnant women were selected as controls. Maternal serum zinc samples were collected. The collected data were entered into the master table. Tabulation, coding, and statistical data analysis were performed using SPSS version 20.0 for Windows. Results: The mean serum zinc levels in the case group and control group were 43,90 ± 15,79 µg/dL (ranged from 15 to 86 µg/dL) and 48,77 ± 10,54 µg/dL (ranged from 22 to 83 µg/dL), respectively. A value of serum zinc levels with the best sensitivity and specificity was 45,5 µg/dL. Conclusion: There was a significant association between maternal serum zinc level with PE. The risk of PE was 3,2 times higher in pregnant women with serum zinc levels of ≤45,5 mcg/dL compared to pregnant women with serum zinc levels of >45,5 mcg/dL. In this case it is necessary to supplement zinc earlier in pregnancy to reduce the risk of preeclampsia.

Background. Preeclampsia is defined as gestational hypertension and proteinuria which can be measured by the elevation of liver transaminases to twice normal concentration, and the symptoms of increased intracranial pressure such as dizziness, blurred vision, and seizures. Zinc is an essential mineral for many biological functions and one of the trace elements that is directly involved in the oxidative/antioxidant balance, a pathogenesis process in preeclampsia that is highly dependent on dietary habits and supplements. This study was aimed to assess the association between serum zinc level with preeclampsia (PE). Methods: This observational, case-control study was performed on 90 women with singleton pregnancies at 28 to 42 weeks of gestation which were referred to the Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin General Hospital, Palembang, between August 2020 to November 2020. 30 pregnant women with PE were selected as cases and 60 healthy pregnant women were selected as controls. Maternal serum zinc samples were collected. The collected data were entered into the master table. Tabulation, coding, and statistical data analysis were performed using SPSS version 20.0 for Windows. Results: The mean serum zinc levels in the case group and control group were 43,90 ± 15,79 µg/dL (ranged from 15 to 86 µg/dL) and 48,77 ± 10,54 µg/dL (ranged from 22 to 83 µg/dL), respectively. A value of serum zinc levels with the best sensitivity and specificity was 45,5 µg/dL. Conclusion: There was a significant association between maternal serum zinc level with PE. The risk of PE was 3,2 times higher in pregnant women with serum zinc levels of ≤45,5 mcg/dL compared to pregnant women with serum zinc levels of >45,5 mcg/dL. In this case it is necessary to supplement zinc earlier in pregnancy to reduce the risk of preeclampsia.

Maternal death is still a problem among pregnant women. One of the most prevalent causes of maternal death is preeclampsia. Preeclampsia contributes not only to maternal death, but also increases fetal morbidity. Early screening for preeclampsia is a key factor to managing the condition. The Fetal Medicine Foundation (FMF) has developed an algorithm to predict preeclampsia during the first trimester of pregnancy. However, there has been lack of studies done in Indonesia its usage. Therefore, this study aims to examine the accuracy of the FMF algorithm as a screening tool to identify preeclampsia in women in the first trimester of pregnancy. //Prospective cohort study done in Obstetrics and Gynecology Department of Mohammad Hoesin Hospital Palembang in January-December 2023. Sixty subjects that met the inclusion criteria were followed from 11 to 13+6 weeks to birth. All subjects undergo history taking for maternal and obstetrics history, physical examination, in particular mean arterial pressure (MAP) measurement, ultrasonography examination to evaluate mean uterine artery pulsatility index (UtA-PI), crown-rump length (CRL), and laboratory testing for pregnancy-associated plasma protein-A [PAPP-A] and placental growth factor [PlGF]. The outcome of this study is the incidence of preeclampsia as well as the detection rate (accuracy rate), false positive rate, positive predictive value (PPV), and negative predictive value (NPV) of the FMF algorithm. Data were analyzed using SPSS version 25.0 with a significance level of p <0.05 and a 95% CI. Kolmogorov Smirnov test was used for data homogeneity, Chi-square or Fisher test for categorical data, One way anova and Kruskal wallis test for numerical data. Sixty subjects were enrolled. Among these, 30 subjects subsequently developed preeclampsia, with 18 (30%) experiencing early-onset preeclampsia, 12 (20%) experiencing late-onset preeclampsia, and 30 (50%) not developing preeclampsia (normotension). There was no significant difference in maternal characteristics and obstetric history among the three groups. MAP is found to be significantly different, with the highest found in the early onset preeclampsia group (p=0.021). Uterine artery pulsatility index (UtA-PI) was significantly higher in early-onset and late-onset preeclampsia subjects (p=0.019). There was no significant difference among the three groups in CRL. Serum PIGF was significantly lower in early onset and late-onset preeclampsia subjects (p-0.0001). Serum PAPP-A is also significantly lower in the early-onset preeclampsia subjects (p=0.0002). The combination of FMF/MAP, UtA-PI, yields the highest accuracy in predicting preeclampsia with 100% values for sensitivity, specificity, PPV, and NPV (p=0,000). The other combinations show lower accuracy, but quite good values of specificity and sensitivity. The FMF algorithm is an accurate screening tool to identify preeclampsia in the first trimester of pregnancy.

Objective of the study is to determine the correlation of placenta and birth weight in late onset preeclampsia. A case-control study,analysis prevalence was conducted in Moh Hoesin Hospital Palembang from August 2015 to August 2016. Samples were women who giving birth in Moh Hoesin Hospital Palembang. They were devided into two groups, severe preeclampsia as case group and normotension as control. Data were analyzed by X2, Exact Fisher’s and logistic regression test using SPSS 16.0. There were 180 subjects (90 cases and 90 controls). There was a positive correlation between placental macroscopic and late onset preeclampsia (p=0.009; OR=6.9), in contrast there was only one different placental microvascularisation of 16, between late onset preeclampsia and normotension, the mural or occlusive fibrin thrombi chorion (p=0.005; OR=9.9). Birth weight in late onset preeclampsia tended to be small but still in normal range and it was not statistictly significant (p=0.112; OR=10.4). There was a positive correlation between placental macroscopic and SGA baby on late onset preeclampsia (p=0.026; OR=16.6), but it wasnot proven microscopically. Placenta remains contributed to the pathogenesis of the late onset preeclampsia, but not as dominant as the early one.