The disparity between the sexes in stroke mortality has been demonstrated in people from different locations. The objective of this study was to analyze the disparity between sexes in stroke mortality in adults in the metropolitan area of Greater Vitoria between 2000 and 2021. Ecological time series design was conducted with a database of the Brazilian Health System Informatics Department. The annual percentage change and average annual percentage change were calculated through joinpoint regression. Pairwise comparisons using parallelism and coincidence tests were applied to compare temporal trends between men and women. Men had higher mortality rates in most years between 2000 and 2021. In contrast, women had higher proportional mortality values in all years evaluated from 2000 to 2021. The paired comparison revealed a disparity between the sexes in the proportional mortality time series (parallelism test: p = 0.003; coincidence test: p < 0.001). However, the time series of the mortality rates showed no disparity between the sexes (parallelism test: p = 0.114; coincidence test: p = 0.093). From 2000 to 2021, there was a disparity in proportional mortality from stroke between the sexes of the population in the metropolitan area of Greater Vitoria, Brazil. However, the time series of mortality rates between the sexes did not reveal any disparity in the study period.

Introduction: Cerebrovascular diseases are among the leading causes of death in the world and correspond to the first cause of overall mortality in the state of Rio Grande do Sul, Brazil. Objective: To analyze the two-decade temporal trend of the stroke mortality rate in the adult population of the state of Rio Grande do Sul, Brazil, from 2000 to 2021. Method: This is an ecological time series study, based on secondary data. Data were extracted from the database of the Informatics Department of the Unified Health System - Datasus. Joinpoint regression models were applied to analyze the temporal trend. Results: The stroke mortality rate in adults in Rio Grande do Sul remained stable throughout the period from 2000 to 2021, with the exception of the segment from 2019 to 2021, a period marked by an increase in the mortality rate in the age group of 40 to 69 years. The analyses of both overall mortality and percentage variation maintained a pattern, indicating that women were the group with the highest mortality, especially with advancing age. Conclusion: From 2000 to 2021, the state of Rio Grande do Sul remained stable, with an epidemiological profile predominant in women and in older age groups, especially those over 80 years old.