Osteoarthritis (OA) is a prevalent form of arthritis worldwide. Intra-articular stromal vascular fraction (SVF) injections are a potential therapeutic option for patients with OA. This study aims to assess the effects of intra-articular SVF injections on knee OA. Ten patients with knee OA participated in this study. After administering them with intra-articular SVF injections, their outcomes were evaluated using various questionnaires. MRI T2 mapping was conducted and compared before the intervention and 6 months after. All the data underwent analysis using various tests. Significant differences were observed in the change of Western Ontario and McMaster Universities Arthritis Index, VAS, and Knee Injury and Osteoarthritis Outcome Score between pre-intervention and 6 months post-intervention. The T2 values were significantly lower in the anterior superficial layer of the medial femoral cartilage and middle superficial layer of the lateral femoral cartilage. However, no positive effects were observed in any other regions of the knee cartilage. This study revealed significant differences between the pre- and 6-month post-intervention questionnaires. However, the T2 values did not show consistent changes across all regions of the knee cartilage. Despite positive effects in two regions, the degenerative process appeared to continue in other regions during the tracking period.

Osteosarcoma is the most common primary malignant bone tumor, predominantly affecting adolescents and young adults. Survival outcomes vary widely, and previous studies have suggested differences in patient characteristics and disease patterns across populations; however, population-based evidence from Taiwan remains limited. In this nationwide retrospective cohort study, data from the Taiwan Cancer Registry were analyzed to evaluate overall survival (OS) and prognostic factors among patients diagnosed between 2013 and 2022. A total of 371 patients were included, with a mean follow-up of 4.6 years. Kaplan–Meier analyses demonstrated significant differences in overall survival according to tumor stage, primary tumor site, and histological grade (all log-rank p < 0.05). In multivariable Cox proportional hazards analyses, older age groups were associated with an increased risk of death, while high-stage disease (AJCC stage III–IV) was associated with a significantly higher risk of mortality compared with low-stage disease (HR = 1.94, 95% CI = 1.30–2.90). In contrast, low-grade histology (HR = 0.31, 95% CI = 0.14–0.71) and limb salvage surgery (HR = 0.38, 95% CI = 0.23–0.64) were associated with improved survival. These findings provide population-based evidence on prognostic factors for osteosarcoma in Taiwan and highlight the associations of age, disease stage, tumor biology, and surgical management with overall survival.