Margherita Caccia

Mrs. Margherita Caccia

orcid

Research Focus & Metrics

Academic Career Length

3Years (2024-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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24 December 2024 in Applied Sciences
Verified
Journal Article
Open access
PDF file
MRMarcella Reguzzoni
Marcella Reguzzoni
ACAndrea Carganico
Andrea Carganico
DPDoriana Lo Presti
Doriana Lo Presti
Piero Antonio ZeccaPiero Antonio Zecca
Piero Antonio Zecca
ESEleonora Ivonne Scurati
Eleonora Ivonne Scurati
Luca LevriniLuca Levrini
Luca Levrini
This study aimed to investigate the remineralization processes of dental enamel via scanning electron microscopy and observe the changes induced in the microstructure by oral hygiene products. More specifically, the effectiveness of Mentadent Professional Resilience was analyzed for its ability to demineralize erosion-affected enamel surfaces. This involved the sectioning of some teeth to preserve enamel integrity, followed by dehydration and preparation for SEM analysis. SEM observations were made at various magnifications to detect differences in enamel morphology after treatment with the product. These observations provide valuable insights into the mechanisms of action of dental care products and their potential to protect enamel. The study makes a contribution to our understanding of remineralization processes and describes the importance of microscopic analysis for evaluating and developing effective dental products.

3 September 2024 in Applied Sciences
Verified
Journal Article
Open access
PDF file
Piero Antonio ZeccaPiero Antonio Zecca
Piero Antonio Zecca
MCMargherita Caccia
Margherita Caccia
LSLea Siani
Lea Siani
Alberto CaprioglioAlberto Caprioglio
Alberto Caprioglio
RFRosamaria Fastuca
Rosamaria Fastuca
Background: The need to perform occasional or continuous MRI exams and the interference with metal orthodontic appliances might be important and take a primary role during retention since the retention period is significantly longer than orthodontic treatment. Several non-metallic materials were proposed as potential alternatives to perform fixed retainers in orthodontics, but they showed internal limits. Methods: Polyetheretherketone (PEEK) was used in the present clinical report as a fixed orthodontic retainer in the lower arch in order to perform an appliance with mechanical properties comparable to metallic ones but with a higher biocompatibility material and without the need for removal in case of an MRI exam. The retainer wire was handmade in the studio and then shaped to fit the arch. Results: PEEK showed a good capability for constructing a lingual fixed retainer compared to other aesthetic non-metallic and metallic materials. Conclusions: To the best of our knowledge, this study proposes how to easily build a retainer in PEEK and provides a clinical example of how this material can be beneficial.

20 October 2024 in Journal of Dentistry
Verified
Journal Article
Open access
Piero Antonio ZeccaPiero Antonio Zecca
Piero Antonio Zecca
MCMargherita Caccia
Margherita Caccia
LLLuca Levrini
Luca Levrini
ACAndrea Carganico
Andrea Carganico
MRMarcella Reguzzoni
Marcella Reguzzoni
MPMarina Protasoni
Marina Protasoni
Artificial Intelligence (AI) in dental diagnostics is evolving, offering innovative approaches for conducting cephalometric analysis with less manual input and overcoming the limitations of traditional imaging methods. To enhance the diagnostic processes in dentistry, an open-source software that utilises AI to improve the extraction of cephalometric values from limited field of view (FOV) images was created. Reduced FOV images lack several vital cephalometric landmarks, prompting the creation of predictive models to estimate missing values. The GridSearchCV algorithm and other algorithms were used to construct predictive models using software and to select the best models. The software was validated by comparing the predicted values with the actual measurements and calculating the mean squared error using Excel. Further validation involved a randomly selected cohort of 25 untreated orthodontic cases. Evaluation of the software showed that it was effective in accurately predicting key cephalometric measurements, suggesting that it could be a reliable tool for clinical use. However, some variations were noted in its predictive accuracy across different measurements, indicating areas that could benefit from further development. The software could align closely with the actual cephalometric measurements through detailed statistical analysis. The integration of AI into cephalometric analysis with the software could represent progress, potentially leading to more efficient dental diagnostics and a reduction in the need for additional X-rays. This study aimed to advance the integration and refinement of AI in healthcare, focusing on minimising bias and understanding its impact on clinical decisions. In future studies, the application of AI in dental practice should be expanded to address these challenges. This software integrates AI into clinical practice to enhance the diagnostic and therapeutic phases for patient benefit. It enables precise and comprehensive cephalometric analyses using data previously considered insufficient, thereby reducing the need for X-rays and improving patient care.

18 July 2024 in Dentistry Journal
Verified
Journal Article
Open access
PDF file
Piero Antonio ZeccaPiero Antonio Zecca
Piero Antonio Zecca
SBSalvatore Bocchieri
Salvatore Bocchieri
ACAndrea Carganico
Andrea Carganico
MCMargherita Caccia
Margherita Caccia
RFRosamaria Fastuca
Rosamaria Fastuca
MRMarcella Reguzzoni
Marcella Reguzzoni
This study presents a scanning electron microscopy analysis of a failed PEEK retainer in an orthodontic patient. After 15 months of use, the patient reported a gap opening between teeth 41 and 42. The PEEK retainer was removed and sent for electron microscope analysis. To investigate the failure, scanning electron microscopy was employed to assess the microstructure and composition of the retainer at various magnifications. These findings suggest that the failure of the PEEK retainer was multifaceted, implicating factors such as material defects, manufacturing flaws, inadequate design, environmental factors, and patient-related factors. In conclusion, this scanning electron microscopy analysis offers valuable insights into the failure mechanisms of PEEK retainers in orthodontic applications. Further research is necessary to explore preventive strategies and optimize the design and fabrication of PEEK retainers, minimizing the occurrence of failures in orthodontic practice.

27 June 2025 in Applied Sciences
Verified
Journal Article
Open access
PDF file
Luca LevriniLuca Levrini
Luca Levrini
Piero Antonio ZeccaPiero Antonio Zecca
Piero Antonio Zecca
MBMARINA BORGESE
MARINA BORGESE
ESEleonora Ivonne Scurati
Eleonora Ivonne Scurati
ADAlessandro Deppieri
Alessandro Deppieri
ACAndrea Carganico
Andrea Carganico
The purpose of this systematic review is to analyze the dentoalveolar changes resulting from the use of clear aligners in the treatment of transverse maxillary deficiency among growing children in the mixed dentition stage. An electronic literature search was carried out using the following databases: PubMed, Scopus, Cochrane Library, Embase, and Web of Science. The review protocol was prospectively registered in the PROSPERO database. Eligible studies included children aged 6 to 12 years in the mixed dentition period, presenting with erupted maxillary first molars and a transverse deficiency of the maxilla, and undergoing treatment with Invisalign® First aligners. The review encompassed various study types including retrospective and prospective designs, randomized controlled trials, preliminary studies, and case series. Two independent reviewers conducted the data extraction process. The quality of evidence was assessed using the GRADE approach. Except for studies by Bruni et al., the risk of bias in selected articles was visually summarized in a traffic light plot using the robvis tool, following the ROBINS-I methodology. For the studies by Bruni et al., a separate visual representation was created using robvis with the RoB2 evaluation framework, prepared by the authors S.E.I. and C.A. In total, 14 studies were included in the final synthesis, selected from 265 records retrieved through electronic searches and an additional 36 identified via manual screening. Several parameters were considered in order to assess dentoalveolar expansion: intercanine width, intercanine transpalatal width, intercanine dentoalveolar width, first and second interdeciduous molar width, first and second interpremolar width, first and second interdeciduous molar transpalatal width, first intermolar width, first intermolar mesial, distal, and transpalatal width, molar inclination, arch depth, and arch perimeter, and intermolar dentoalveolar width. An improvement was recorded in all parameters. The studies comparing treatment with Invisalign® First clear aligners and rapid maxillary expander highlighted that these both determined statistically significant differences compared to the natural growth group. Treatment with Invisalign® First in mixed dentition proved to be very effective for dentoalveolar expansion of the maxillary arch, with good control of the crown angulation of the upper first molar and an increase in the palatal area similar to RME, compared to pre-treatment or to the natural growth group. It could represent an effective and comfortable alternative to the traditional rapid maxillary expander treatment. However, further high-quality studies are required to support our current observations and verifying the stability of treatment outcomes on a long-term basis.

29 October 2024 in Applied Sciences
Verified
Journal Article
Open access
PDF file
Luca LevriniLuca Levrini
Luca Levrini
Piero Antonio ZeccaPiero Antonio Zecca
Piero Antonio Zecca
ADAlessandro Deppieri
Alessandro Deppieri
MCMargherita Caccia
Margherita Caccia
ESEleonora Ivonne Scurati
Eleonora Ivonne Scurati
ACAndrea Carganico
Andrea Carganico
The aim of this study is to retrospectively investigate the predictability of maxillary arch expansion with Invisalign ® First in mixed dentition. In a sample of 64 treated patients, 3D digital models from the ClinCheck® software were compared with post-treatment digital models. Predicted maxillary expansion was related to the final outcome of expansion. At the cuspidal level, there was observed a predictability of 59.68% for deciduous canines, 63.77% for first deciduous molars, 66.99% for second deciduous molars, and 55.61% for first permanent molars. At the gingival level, there was observed a predictability of 49.87% for deciduous canines, 53.11% for first deciduous molars, 53.36% for second deciduous molars, and 45.16% for first permanent molars. The difference between the predicted and achieved expansion was statistically significant (p < 0.05). Within the present limitations, our results suggest that, with Invisalign® First, it is possible to expand the upper arch in mixed dentition in an effective and predictable way. Clear aligners could represent a new and valid alternative for arch expansion in growing patients.