Silver nanoparticles, with various uses in pharmacy, cosmetics, sanitation, textiles, optoelectronics, photovoltaics, etc., that are provided by worldwide industrial production, estimated to hundreds of tons annually, are finally released in the environment impacting randomly the biosphere. An alternative synthesis approach could be implemented by replacing chemical reductants of silver with natural antioxidants ensuring production and utilization sustainability with focus on environmental pollution diminishing. We synthesized silver nanoparticles by using plant extracts, aiming to offer antimicrobial products with reduced impact on the environment through sustainable green-chemistry. Fresh extracts of lemon pulp, blueberry and blackberry fruits as well as of green tea dry leaves were the sources of the natural antioxidants able to ensure ionic silver reduction and silver nanoparticle formation in the form of colloidal suspensions. The four samples were characterized by UV–Vis spectrophotometry, scanning electron microscopy, dark field optical microscopy, X-ray diffractometry, dynamic light scattering, which evidenced specific fine granularity, plasmonic features, standard crystallinity, and good stability in water suspension. Antimicrobial activity was assayed using the agar diffusion method and the bacteria kill-time technique against Staphylococcus aureus and Escherichia coli. In both cases, all silver nanoparticles revealed their adequacy for the aimed purposes, the sample synthesized with green tea showing the best efficiency, which is in concordance with its highest contents of polyphenols, flavones and best total antioxidant activity. Various applications could be safely designed based on such silver nanoparticles for sustainable chemistry development.