A new type of parallel, label-free target detection based on the combination of chip electrophoresis and a nanoparticle optical biosensor is reported.

Chip-electrophoresis-based separation was combined with an RET optical sensor to establish a new sense of a simultaneous label-free multi-drug screening method.

Metal organic framework–chiral ionic liquid composites Fe-CIL was first used to construct the chiral sensor, which could be used to chiral recognize tryptophan (Trp) enantiomers based on the DPV peak potential difference (ΔE_p) of l/d-Trp.