Prof. Paulo Martins Da Costa

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Academic Career Length

21Years (2006-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

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14 January 2013 in International Journal of Environmental Research and Public Health

Journal Article

Transfer of Multidrug-Resistant Bacteria Between Intermingled Ecological Niches: The Interface Between Humans, Animals and the Environment

Paulo Martins Da Costa

Luis Filipe L De J Loureiro

Augusto Matos

The use of antimicrobial agents has been claimed to be the driving force for the emergence and spread of microbial resistance. However, several studies have reported the presence of multidrug-resistant bacteria in populations exposed to low levels of antimicrobial drugs or even never exposed. For many pathogens, especially those organisms for which asymptomatic colonization typically precedes infection (e.g., Enterococcus spp. and Escherichia coli), the selective effects of antimicrobial use can only be understood if we considerer all biological and environmental pathways which enable these bacteria, and the genes they carry, to spread between different biomes. This ecological framework provides an essential perspective for formulating antimicrobial use policies, precisely because it encompasses the root causes of these problems rather than merely their consequences.

1 May 2006 in Water Research

Journal Article

Antimicrobial resistance in Enterococcus spp. isolated in inflow, effluent and sludge from municipal sewage water treatment plants

Paulo Martins Da Costa

Paulo Vaz-Pires

Fernando Bernardo

1 January 2009 in Emerging Infectious Diseases

Journal Article

Seagulls and Beaches as Reservoirs for Multidrug-ResistantEscherichia coli

Roméo Rocha Simões

Laurent Poirel

Paulo Martins Da Costa

Patrice Nordmann

A variety of extended-spectrum β-lactamase–producing Escherichia coli isolates, with a high rate of cefotaximase-15 resistance, were identified in seagull feces from Porto, Portugal, beaches. Beaches may therefore present a risk to public health because of the potential pathogen-spreading capacity of migratory birds.

1 September 2017 in Phytochemistry

Journal Article

Antibacterial and antibiofilm activities of the metabolites isolated from the culture of the mangrove-derived endophytic fungus Eurotium chevalieri KUFA 0006

28 January 2014 in Marine Drugs

Journal Article

Antibacterial and Antibiofilm Activities of Tryptoquivalines and Meroditerpenes Isolated from the Marine-Derived Fungi Neosartorya paulistensis, N. laciniosa, N. tsunodae, and the Soil Fungi N. fischeri and N. siamensis

Nelson Gomes

Lucinda J. Bessa

Suradet Buttachon

Paulo Martins Da Costa

Jamrearn Buaruang

Anake Kijjoa

A new meroditerpene, sartorypyrone C (5), was isolated, together with the known tryptoquivalines L (1a), H (1b), F (1c), 3′-(4-oxoquinazolin-3-yl) spiro [1H-indole-3,5′]-2,2′-dione (2) and 4(3H)-quinazolinone (3), from the culture of the marine sponge-associated fungus Neosartorya paulistensis (KUFC 7897), while reexamination of the fractions remaining from a previous study of the culture of the diseased coral-derived fungus N. laciniosa (KUFC 7896) led to isolation of a new tryptoquivaline derivative tryptoquivaline T (1d). Compounds 1a–d, 2, 3, and 5, together with aszonapyrones A (4a) and B (4b), chevalones B (6) and C (7a), sartorypyrones B (7b) and A (8), were tested for their antibacterial activity against four reference strains (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa), as well as the environmental multidrug-resistant isolates. Only aszonapyrone A (4a) and sartorypyrone A (8) exhibited significant antibacterial activity as well as synergism with antibiotics against the Gram-positive multidrug-resistant strains. Antibiofilm assays of aszonapyrone A (4a) and sartorypyrone A (8) showed that practically no biofilm was formed in the presence of their 2× MIC and MIC. However, the presence of a sub-inhibitory concentration of ½ MIC of 4a and 8 was found to increase the biofilm production in both reference strain and the multidrug-resistant isolates of S. aureus.

14 October 2014 in Marine Drugs

Journal Article

New Isocoumarin Derivatives and Meroterpenoids from the Marine Sponge-Associated Fungus Aspergillus similanensis sp. nov. KUFA 0013

Two new isocoumarin derivatives, including a new 5-hydroxy-8-methyl-2H, 6H-pyrano[3,4-g]chromen-2,6-dione (1) and 6,8-dihydroxy-3,7-dimethylisocoumarin (2b), a new chevalone derivative, named chevalone E (3), and a new natural product pyripyropene S (6) were isolated together with 6, 8-dihydroxy-3-methylisocoumarin (2a), reticulol (2c), p-hydroxybenzaldehyde, chevalone B, chevalone C, S14-95 (4), and pyripyropene E (5) from the ethyl acetate extract of the undescribed marine sponge-associated fungus Aspergillus similanensis KUFA 0013. The structures of the new compounds were established based on 1D and 2D NMR spectral analysis, and in the case of compound 3, X-ray analysis was used to confirm its structure and the absolute configuration of its stereogenic carbons. Compounds 1, 2a–c and 3–6 were evaluated for their antimicrobial activity against Gram-positive and Gram-negative bacteria, Candida albicans ATCC 10231, and multidrug-resistant isolates from the environment. Chevalone E (3) was found to show synergism with the antibiotic oxacillin against methicillin-resistant Staphylococcus aureus (MRSA).

About Me

Prof. Paulo Martins da Costa, DVM and PhD in Biomedical Sciences PhD, is a Full Professor and leader of the Laboratory of Microbiology (aquatic Production Department) at ICBAS-U.Porto. Since 2002, he has been involved in several studies about the phenotypic and genotypic characterization of MDR bacteria disseminated in several populations (humans, livestock species, pets, wild animals) and intermingled ecological niches. Well-aware of the problem of antimicrobial resistance, he joined to a large research team dedicated to the discovery of new antimicrobial agents, being co-author of six international patents. Paulo Martins da Costa has led and integrated the team of 3 and 25 research projects, respectively, and he has published 90 peer-reviewed articles published in international journals, involving a wide range of sample types, bacterial species. These works demonstrate a strong interest in the One Health perspective, and in the development of solutions with high economic and societal value. Besides his role as a university professor, he has been involved in educational and training events that include pharmaceutical companies, veterinary and public hospitals. He also advises technical and consulting services offered to economic activities and public entities, and he is a member of the Interdisciplinary Centre of Marine and Environmental Research (CIIMAR).

Prof. Paulo Martins Da Costa

Prof. Paulo Martins Da Costa

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