This study aims to determine the association between temperature and preeclampsia and whether it is affected by seasonality and rural/urban lifestyle. This cohort study included women who delivered at our medical center from 2004 to 2013 (31,101 women, 64,566 deliveries). Temperature values were obtained from a spatiotemporally resolved estimation model performing predictions at a 1×1km spatial resolution. In “Warm” pregnancies >50% of gestation occurred during the spring-summer period. In cold pregnancies >50% of gestation occurred during the fall and winter. Generalized estimating equation multivariable models were used to estimate the association between temperature and incidence of preeclampsia. 1) The incidence of preeclampsia in at least one pregnancy was 7% (2173/64,566); 2) during “warm” pregnancies, an elevation of one IQR of the average temperature in the 1^st or the 3^rd trimesters was associated with an increased risk to develop preeclampsia [patients with Jewish ethnicity: 1^st trimester: relative risk (RR) of 2.38(95%CI 1.50; 3.80), 3^rd trimester 1.94(95%CI 1.34;2.81); Bedouins: 1^st trimester: RR = 2.91(95%CI 1.98;4.28), 3^rd trimester: RR = 2.37(95%CI 1.75;3.20)]; 3) In “cold” pregnancies, an elevation of one IQR of average temperature was associated with a lower risk to develop preeclampsia among patients with Bedouin-Arab ethnicity RR = 0.68 (95% CI 0.49–0.94) for 1^st trimester and RR = 0.62 (95% CI 0.44–0.87) for 3^rd trimester. 1) Elevated averaged temperature during the 1^st or 3^rd trimesters in “warm” pregnancies confer an increased risk for the development of preeclampsia, especially in nomadic patients; 2) Of interest, during cold pregnancies, elevated averaged temperature was associated with a lower risk to develop preeclampsia for nomadic patients. 3) These findings suggest temperature might be associated with perturbations in maternal heat homeostasis resulting in reallocation of energy resources and their availability to the fetus that may increase the risk for preeclampsia. This observation is especially relevant in the context of global warming and its effects on maternal/fetal reproductive health.

Background The physician in triage (PIT) strategy was implemented in the emergency department (ED) of the Soroka University Medical Center (SUMC) to improve overcrowding and waiting time. Our objective in the current study was to assess the impact of the PIT strategy on door-to-balloon time for the treatment of acute ST-elevation myocardial infarction (STEMI). Methods The PIT programme began on January 2016, working weekdays between 8:00 and 23:00 hours. We included patients who visited the ED and were diagnosed with STEMI, from November 2014 to February 2018. The primary outcome was improvement in door-to-balloon (D2B) time <90 min between the preintervention and postintervention period. The analysis included a comparison between the two time periods using univariate tests, a time trend analysis illustrated by the locally weighted scatterplot smoothing curves and a regression analysis using generalised estimating equation models. To determine the impact of the PIT, as opposed to other changes in the department, we stratified the population arriving after January 2016 to patients arriving during PIT hours versus patients arriving on weekends and at nights (23:00–8:00 hours). Results In all, 415 patients met all the inclusion criteria of which 237 (57.1%) visited on weekdays 8:00–23:00 hours. The per cent of patients with D2B <90 min was 13.9% higher for postintervention versus preintervention visits (p=0.006). D2B time was significantly shorter by 9 min for postintervention visits (p=0.001). In the postintervention period, patients arriving between 8:00 and 23:00 hours on weekdays were more likely to have D2B <90 min than those arriving nights and weekends; 90/146 (61.6%) vs 47.2% (51/108), respectively, p=0.02. ORs for D2B <90 min was 2.04 (95% CI 1.06 to 3.91) for weekday visits, and 1.90 (0.88 to 4.12) for weekend and night visits. Conclusion The PIT model in SUMC is associated with D2B reduction for patients with STEMI. To achieve further reduction, both targeted interventions should be performed and PIT strategy should be applied for full time, including nights and weekends.

The study aimed to compare eye outcomes between the standard and accelerated corneal cross-linking (CXL) protocols over a 1-year follow-up, and assess whether the accelerated protocols are non-inferior to the standard. A retrospective cohort study including patients older than 18 years diagnosed with progressive keratoconus who underwent a CXL procedure. The primary outcome was defined as an increase of more than 1.5 diopter (D) in Kmax. The analysis included intra- and inter-group comparisons assessing differences in eye characteristics before and 12 months after the procedure. Furthermore, we assessed whether the accelerated procedures were non-inferior to the standard regarding Kmax change after 12 months. Eighty-four patients included in the study of which 23, 37 and 23 underwent the standard CXL (group I), 10-min. (group II) and the 3-min. (group III) accelerated procedures, respectively. Intra-group comparison before and after 12 months of mean Ksteep and anterior corneal astigmatism showed significant improvement only for group I (–0.3D decrease for both). Inter-group comparison showed better results after 12 months for group I (–0.9 ± 1.2) compared to group III (0.1 ± 0.8) in Ksteep, Kmean (–0.5+1. vs 0.1+0.7, respectively) and anterior astigmatism (–0.5 + 0.9 vs 0.3+1.1, respectively). We could not declare that the accelerated CXLs are non-inferior to the standard (p-value = 0.11 and 0.15). The standard CXL showed better results for keratometry and astigmatism in comparison with the accelerated. Therefore, the wide use of the accelerated CXL should be considered and reviewed for longer follow-up time and larger sample size in focus on the visual acuity parameters.

Background: One of the greatest challenges of modern health systems is the choice and use of resources needed to diagnose and treat patients. Medical practice variation (MPV) is a broad term which entails the differences between health care providers inclusive of both the overuse and underuse. In this paper, we describe a 3-phase research protocol examining MPV in primary care. Objective: We aim to identify the potential targets for behavioral modification interventions to reduce the variation in practice patterns and thus improve health care, decrease costs, and prevent disparities in care. Methods: The first phase will delineate the variation in primary care practice over a wide range of services and long follow-up period (2003-2017), the second will examine the 3 determinants of variation (ie, patient, physician, and clinic characteristics), and attempt to derive the unexplained variance. In the third phase, we will assess a novel component that might contribute to the previously unexplained variance - the physicians’ personal behavioral characteristics (such as risk aversion, fear of malpractice, stress from uncertainty, empathy, and burnout). Results: This work was supported by the research grant from Israel National Institute for Health Policy Research (Grant No. 2014/134). Soroka University Medical Center Institutional Ethics Committee has approved the updated version of the study protocol (SOR-14-0063) in February 2019. All relevant data for phases 1 and 2, including patient, physician, and clinic, were collected from the Clalit Health Services data set in 2019 and are currently being analyzed. The evaluation of the individual physician characteristics (eg, risk aversion) by the face-to-face questionnaires was started on 2018 and remains in progress. We intend to publish the results during 2020-2021. Conclusions: Based on the results of our study, we aim to propose a list of potential targets for focused behavioral intervention. Identifying new targets for such an intervention can potentially lead to a decrease in the unwarranted variation in the medical practice. We suggest that such an intervention will result in optimization of the health system, improvement of health outcomes, reduction of disparities in care and savings in cost. International Registered Report Identifier (IRRID): DERR1-10.2196/18673

Introduction . Keratoconus is a progressive corneal disease commonly treated by collagen cross‐linking (CXL). Accelerated protocols have recently become common. This study sought to compare the outcomes of accelerated and standard CXL in terms of visual acuity, keratometry, and tomographic parameters in pediatric population. Methods . We retrospectively reviewed the files of pediatric patients who underwent standard and accelerated CXL for keratoconus in our hospital, between October 2014 and March 2018. Changes in uncorrected distance visual acuity (UCDVA), best corrected distance visual acuity (BCDVA), tomographic keratometry parameters ( K _max , K _steep , K _flat , K _mean ), and endothelial density count (EDC) were assessed before and at 6 and 12 months following treatment. The analysis included intergroup and intragroup comparisons. Results . This study included 53 eyes (44 patients). Fourteen eyes were treated with standard CXL (S‐CXL, 3 mW/cm ² , 30 min), while 39 underwent accelerated CXL (A‐CXL, 9 mW/cm ² , 10 min). Intergroup comparison found insignificant differences between groups, with the exception of better results for UCDVA in the S‐CXL group after 12 months ( P = 0.03). In this study, there was no significant difference between the two protocols postoperatively in BCDVA, K _max , K _mean , pachymetry, or corneal astigmatism. Conclusion . A‐CXL is as safe and effective as S‐CXL for stabilizing progressive keratoconus in pediatric population. Larger‐sample‐size studies with a longer follow‐up time are required. Considering the long‐term results of 9 mW A‐CXL and its safety and efficacy profile, it should be preferred to S‐CXL for reducing treatment time and improving patients’ comfort.

Background: ST-Elevation Myocardial Infarction (STEMI) is a critical condition, especially in the older population, who are at increased risk due to comorbidities and delayed diagnosis. This study aimed to investigate the impact of ethnicity on the clinical characteristics, treatment timelines, and outcomes of older patients with STEMI in southern Israel, comparing Jewish and Bedouin populations. Methods: We conducted a retrospective cohort study at Soroka University Medical Center from 2016 to 2022, including older patients (≥ 65 years) diagnosed with STEMI. Patients were grouped by ethnicity: Jews and Bedouins. Data on demographics, comorbidities, treatment timelines, and clinical outcomes were collected. Statistical analysis included a comparison analysis and a multivariable logistic regression, adjusting for potential confounders. Results: 575 older patients diagnosed with STEMI were included in the study, of them 469 Jews (81.6%) and 106 Bedouins (18.4%). The mean age of the cohort was 74.35 ± 7.33 years, with no significant difference between Jews (74.56 years 7.53) and Bedouins (73.40 ± 5.99 years, p = 0.139). Bedouins had higher rates of diabetes (53.8% vs. 40.7%, p = 0.019) and smoking (40.6% vs. 27.9%, p = 0.015) and were less likely to arrive by ambulance (39.6% vs. 62.5%, p < 0.00). Bedouins also experienced longer median times from pain onset to first medical contact (126.5 min vs. 90.0 min, p = 0.006) and total ischemic time (240.0 min vs. 205.0 min, p = 0.003). Despite these differences, there were no significant differences in in-hospital mortality (13.2% Bedouins vs. 10.9% Jews, p = 0.606), 30-day mortality (14.2% Bedouins vs. 11.5% Jews, p = 0.556), or one-year mortality (21.7% Bedouins vs. 20.9% Jews, p = 0.959). Multivariable analysis confirmed no significant association between ethnicity and mortality outcomes. Conclusions: Despite the higher prevalence of comorbidities among Bedouin patients, less likely to arrive by ambulance, and experienced longer delays in receiving care, their mortality outcomes were comparable to Jewish patients. These findings highlight the effectiveness of the acute care system in southern Israel. However, further research is needed to explore potential differences in other outcomes, such as quality of life and functional recovery, to better address healthcare disparities in this population.