Anatoly Yambartsev

Dr. Anatoly Yambartsev

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Research Focus & Metrics

Academic Career Length

24Years (2003-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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31 July 2012 in Journal of Statistical Physics
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Journal Article
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MKMaxim Krikun
Maxim Krikun
AYAnatoly Yambartsev
Anatoly Yambartsev

13 October 2016 in Biology Direct
Verified
Journal Article
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AYAnatoly Yambartsev
Anatoly Yambartsev
MPMichael A. Perlin
Michael A. Perlin
YKYevgeniy Kovchegov
Yevgeniy Kovchegov
NSNatalia Shulzhenko
Natalia Shulzhenko
KMKarina L. Mine
Karina L. Mine
AMAndrey Morgun
Andrey Morgun
Gene covariation networks are commonly used to study biological processes. The inference of gene covariation networks from observational data can be challenging, especially considering the large number of players involved and the small number of biological replicates available for analysis. We propose a new statistical method for estimating the number of erroneous edges in reconstructed networks that strongly enhances commonly used inference approaches. This method is based on a special relationship between sign of correlation (positive/negative) and directionality (up/down) of gene regulation, and allows for the identification and removal of approximately half of all erroneous edges. Using the mathematical model of Bayesian networks and positive correlation inequalities we establish a mathematical foundation for our method. Analyzing existing biological datasets, we find a strong correlation between the results of our method and false discovery rate (FDR). Furthermore, simulation analysis demonstrates that our method provides a more accurate estimate of network error than FDR. Thus, our study provides a new robust approach for improving reconstruction of covariation networks. This article was reviewed by Eugene Koonin, Sergei Maslov, Daniel Yasumasa Takahashi.

1 June 2019 in Statistics & Probability Letters
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Journal Article
Closed access
ALA. Logachov
A. Logachov
OLO. Logachova
O. Logachova
AYAnatoly Yambartsev
Anatoly Yambartsev

14 July 2011 in BMC Bioinformatics
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Journal Article
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JSJeff Skinner
Jeff Skinner
YKYuri Kotliarov
Yuri Kotliarov
SVSudhir Varma
Sudhir Varma
KMKarina L Mine
Karina L Mine
AYAnatoly Yambartsev
Anatoly Yambartsev
AMAndrey Morgun
Andrey Morgun
Background: DAPfinder and DAPview are novel BRB-ArrayTools plug-ins to construct gene coexpression networks and identify significant differences in pairwise gene-gene coexpression between two phenotypes. Results: Each significant difference in gene-gene association represents a Differentially Associated Pair (DAP). Our tools include several choices of filtering methods, gene-gene association metrics, statistical testing methods and multiple comparison adjustments. Network results are easily displayed in Cytoscape. Analyses of glioma experiments and microarray simulations demonstrate the utility of these tools. Conclusions: DAPfinder is a new friendly-user tool for reconstruction and comparison of biological networks.

15 August 2024 in Mathematics
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VGVladimir Vasilyevich Glinskiy
Vladimir Vasilyevich Glinskiy
YIYulia Ismayilova
Yulia Ismayilova
SKSergey Khrushchev
Sergey Khrushchev
ALArtem Logachov
Artem Logachov
OLOlga Logachova
Olga Logachova
KZKirill Zaykov
Kirill Zaykov
The Jarque–Bera test is commonly used in statistics and econometrics to test the hypothesis that sample elements adhere to a normal distribution with an unknown mean and variance. This paper proposes several modifications to this test, allowing for testing hypotheses that the considered sample comes from: a normal distribution with a known mean (variance unknown); a normal distribution with a known variance (mean unknown); a normal distribution with a known mean and variance. For given significance levels, α=0.05 and α=0.01, we compare the power of our normality test with the most well-known and popular tests using the Monte Carlo method: Kolmogorov–Smirnov (KS), Anderson–Darling (AD), Cramér–von Mises (CVM), Lilliefors (LF), and Shapiro–Wilk (SW) tests. Under the specific distributions, 1000 datasets were generated with the sample sizes n=25,50,75,100,150,200,250,500, and 1000. The simulation study showed that the suggested tests often have the best power properties. Our study also has a methodological nature, providing detailed proofs accessible to undergraduate students in statistics and probability, unlike the works of Jarque and Bera.

21 June 2016 in Journal of Applied Probability
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MGMark Gannon
Mark Gannon
EPE. Pechersky
E. Pechersky
ISIouri SOUKHOV
Iouri SOUKHOV
AYAnatoly Yambartsev
Anatoly Yambartsev
We propose a class of models of random walks in a random environment where an exact solution can be given for a stationary distribution. The environment is cast in terms of a Jackson/Gordon–Newell network although alternative interpretations are possible. The main tool is the detailed balance equations. The difference compared to earlier works is that the position of the random walk influences the transition intensities of the network environment and vice versa, creating strong correlations. The form of the stationary distribution is closely related to the well-known product formula.