This study aimed to analyze the variations in groundwater quality, vulnerability and potential health risk from 2006 to 2016 in the Limin District, Harbin, China. Groundwater geochemical characteristics were described using statistical analysis and Piper diagrams. A modified DRASTIC model that combined factors of intrinsic aquifer vulnerability and land use was applied to assess groundwater vulnerability. The weights of parameters were adjusted by using the analytic hierarchy process (AHP) to optimize the model. The non-carcinogenic health risk was estimated by the Unites States Environmental Protection Agency (USEPA) model. Results suggested that concentrations of NH₄-N, Fe and Mn in groundwater exceeded the limits both in 2006 and in 2016. The concentration of Fe in the groundwater showed more significant variation between 2006 and 2016 than the other parameters. Very high vulnerability zones increased from 6.3% in 2006 to 16.9% in 2016, and distributed on agricultural land, indicating that agriculture was still a major source of pollution. Mn and NO₃-N contributed the most to human health risks in 2006 and 2016, respectively. This study highlights the influence of groundwater quality variation in decadal exploitation on human health.