Generative Adversarial Networks are a class of artificial intelligence algorithms that consist of a generator and a discriminator trained simultaneously through adversarial training. GANs have found crucial applications in various fields, including medical imaging. In healthcare, GANs contribute by generating synthetic medical images, enhancing data quality, and aiding in image segmentation, disease detection, and medical image synthesis. Their importance lies in their ability to generate realistic images, facilitating improved diagnostics, research, and training for medical professionals. Understanding its applications, algorithms, current advancements, and challenges is imperative for further advancement in the medical imaging domain. However, no study explores the recent state-of-the-art development of GANs in medical imaging. To overcome this research gap, in this extensive study, we began by exploring the vast array of applications of GANs in medical imaging, scrutinizing them within recent research. We then dive into the prevalent datasets and pre-processing techniques to enhance comprehension. Subsequently, an in-depth discussion of the GAN algorithms, elucidating their respective strengths and limitations, is provided. After that, we meticulously analyzed the results and experimental details of some recent cutting-edge research to obtain a more comprehensive understanding of the current development of GANs in medical imaging. Lastly, we discussed the diverse challenges encountered and future research directions to mitigate these concerns. This systematic review offers a complete overview of GANs in medical imaging, encompassing their application domains, models, state-of-the-art results analysis, challenges, and research directions, serving as a valuable resource for multidisciplinary studies.

Predictive maintenance is essential for ensuring the reliability and efficiency of wind energy systems. Traditional deep learning models for sensor fault detection rely solely on data-driven patterns, often lacking interpretability and robustness. This paper proposes a Physics-Guided Bayesian Neural Network (PINN-BNN) model that integrates physics-informed learning with Bayesian inference to improve fault detection in wind turbines. The proposed approach enforces domain-specific constraints to ensure physically consistent predictions while quantifying uncertainty for risk-aware decision-making. The model is evaluated using a real-world wind turbine sensor dataset, achieving an accuracy of 97.6%, a recall of 91.8%, and an AUC-ROC of 0.987. The SHapley Additive exPlanations (SHAP) analysis reveals that gearbox temperature, blade vibration, and generator torque are the most critical features influencing failure predictions. Bayesian uncertainty estimation further improves interpretability by assigning confidence levels to each prediction. A comparative study with ten baseline models, including Long Short-Term Memory (LSTM), Transformer-based models, and traditional machine learning classifiers, demonstrates that the PINN-BNN model outperforms existing approaches while maintaining computational efficiency with a training time of 39.8 minutes and an inference time of 1.7 ms per sample. The integration of physics-informed learning ensures that the model generalizes well to varying environmental conditions, reducing false negatives and minimizing unexpected system failures. The proposed methodology presents a step toward interpretable and reliable predictive maintenance in wind energy systems.

Brain tumor segmentation is crucial in medical imaging, allowing informed diagnosis and treatment planning. In this study, we propose TuSegNet, a new transformer-based and attention-enhanced architecture for robust brain tumor segmentation. The model combines convolutional layers with transformer blocks for global context awareness, incorporates Atrous Spatial Pyramid Pooling (ASPP) for multi-scale feature extraction, and employs channel attention mechanisms to concentrate on tumor-relevant parts. Evaluated on three datasets—Dataset A, Dataset B, and a combined dataset—TuSegNet achieves state-of-the-art performance with a Dice Similarity Coefficient (DSC) of 0.895, 0.910, and 0.930, respectively, and an Intersection over Union (IoU) of 0.820, 0.835, and 0.860. Ablation studies validate the importance of ASPP and attention mechanisms, while comparative analysis demonstrates outstanding performance over existing SOTA models such as Swin UNet and TransUNet. The proposed methodology improves segmentation accuracy and highlights the importance of hybrid architectures in handling complex medical imaging tasks. These developments underscore the potential of TuSegNet for real-world healthcare applications in brain tumor diagnosis.

Objectives: Alzheimer’s disease (AD) remains one of the most prevalent neurodegenerative conditions among older adults, underscoring the urgent need for accurate and ethically grounded early detection methods. Artificial intelligence (AI) techniques, particularly machine learning and deep learning models, show promise in leveraging neuroimaging biomarkers to support early diagnosis. However, significant challenges persist regarding model explainability, accountability, and responsible implementation in real-world healthcare settings. This study presents a generalized Responsible AI (RAI) framework composed of four core components—explainability, fairness, predictive performance, and uncertainty quantification—to address these challenges. Method: Using the TADPOLE neuroimaging dataset, we implemented a Feedforward Neural Network (FNN) within a unified Responsible AI (RAI) framework integrating explainability, fairness, predictive performance, and uncertainty quantification. Although Random Forest achieved slightly higher predictive accuracy (95%), the FNN was selected as the primary model because it better supports end-to-end uncertainty estimation through Monte Carlo Dropout, enabling more reliable clinical decision support. Results: The proposed framework demonstrated strong predictive performance (92% accuracy), improved fairness reflected by an equalized odds difference of 0.124, and progressively lower predictive entropy across training iterations, indicating enhanced confidence in predictions. The framework further enabled model transparency through explainability analyses and supported the identification of low-confidence predictions for potential clinical review. Conclusions: Our findings highlight not only the feasibility of integrating RAI principles into AD prediction pipelines but also the persistent challenges of applying such frameworks to real-world clinical data. This work contributes practical insights toward operationalizing Responsible AI in healthcare contexts.