This paper presents the results of the integration, commissioning, and in-orbit calibration of the ARGUS 2000 SWIR wavelength spectrometer onboard the Colombian FACSAT-2 satellite, Colombia’s first satellite used for the measurement of greenhouse gases (GHG). The satellite has been in orbit for approximately one year, gathering spectral signatures in order to characterize the data and perform calibration. The calibration represents a certain behavior following a second-order adjustment. For data analysis, retrieval algorithms have been developed to obtain synthetic spectra using the Genspect 1.2 software code. These synthetic spectra were obtained from the spectroscopic data associated with atmospheric gases (H₂O, O₂, CO, and CO₂), which are stored in the HITRAN database. Attempting to achieve a more accurate simulation of the experimental spectrum, certain instrumental parameters have been incorporated into the synthetic spectrum, including the resolution of the spectrometer, the field of view (FOV) angle of observation, the limited quantum efficiency of detection, and the slit function. As a result, six slit functions were tested, with the Gaussian and the diffraction functions proving to be the most effective. Finally, a profile of Total Carbon Column Observing Network (TCCON) concentrations was used for comparison with a spectral signature acquired by FACSAT-2, resulting in a close match between the synthetic spectrum and the measured spectrum.