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Prof. Octavio P Luzardo
Affiliation 1: Toxicology Department, Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain. Affiliation 2: CIBER OBN, Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition, Carlos III Health Institute, Madrid, Spain.

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0 Chromatography
0 Environmental Health
0 Food Safety
0 Mass Spectrometry
0 Risk Assessment

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Micro article
Published: 01 August 2021 in MethodsX
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Soil is one of the environmental compartments most affected by pollution. From this medium, the organic compounds can be emitted to the groundwater, the atmosphere, or the biota. Thus, having adequate methods of analysis of organic pollutants in this matrix is essential. However, the soil is a very complex matrix whose organic and inorganic components can determine the degree to which they are retained. Therefore, the methods must account for the various soil characteristics. In this study, the performance of an extraction method that had been already validated in clay loam soils for more than 300 organic compounds of very different nature including pesticides, PhACs, ARs, and POPs has been evaluated in four additional representative soil types of the agricultural land of the Canary archipelago: sandy loam, sandy clay, clay and loamy sand. For this purpose, recovery experiments have been performed at a single concentration (50 ng g−1) in each soil type. When there is a significant difference according to the criteria applied for a given compound, a factor has been calculated to correct the difference in performance in each soil type.

ACS Style

Andrea Acosta-Dacal; Cristian Rial-Berriel; Ricardo Díaz-Díaz; María Del Mar Bernal-Suárez; Manuel Zumbado; Luis Alberto Henríquez-Hernández; Ana Macías-Montes; Octavio P. Luzardo. Extension of an extraction method for the determination of 305 organic compounds in clay-loam soil to soils of different characteristics. MethodsX 2021, 8, 101476 .

AMA Style

Andrea Acosta-Dacal, Cristian Rial-Berriel, Ricardo Díaz-Díaz, María Del Mar Bernal-Suárez, Manuel Zumbado, Luis Alberto Henríquez-Hernández, Ana Macías-Montes, Octavio P. Luzardo. Extension of an extraction method for the determination of 305 organic compounds in clay-loam soil to soils of different characteristics. MethodsX. 2021; 8 ():101476.

Chicago/Turabian Style

Andrea Acosta-Dacal; Cristian Rial-Berriel; Ricardo Díaz-Díaz; María Del Mar Bernal-Suárez; Manuel Zumbado; Luis Alberto Henríquez-Hernández; Ana Macías-Montes; Octavio P. Luzardo. 2021. "Extension of an extraction method for the determination of 305 organic compounds in clay-loam soil to soils of different characteristics." MethodsX 8, no. : 101476.

Journal article
Published: 05 June 2021 in Toxics
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Dry feed for pets lacks specific legislation regarding maximum residue limits for inorganic elements. The aim of the present study was to determine the content of 43 inorganic elements in dog and cat feed, studying whether there were differences according to the supposed quality of the food and performing the risk assessment for health. Thirty-one and thirty packages of pelleted dry food for cats and dogs, respectively, were analyzed. After acidic microwave-assisted digestion, elements were detected and quantified by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). In general, we did not observe important differences in the content of elements according to the supposed quality of the brand. Among trace elements, selenium and manganese are above the dietary reference value. Arsenic and mercury showed the highest acute hazard indexes, which make them risk factors for the health of dogs and cats. Aluminum, uranium, antimony and vanadium contents were above the toxic reference value and showed the highest acute hazard indexes. It is necessary to improve the legislation regarding the food safety of pets, for their health and to protect the rights of consumers.

ACS Style

Ana Macías-Montes; Manuel Zumbado; Octavio Luzardo; Ángel Rodríguez-Hernández; Andrea Acosta-Dacal; Cristian Rial-Berriel; Luis Boada; Luis Henríquez-Hernández. Nutritional Evaluation and Risk Assessment of the Exposure to Essential and Toxic Elements in Dogs and Cats through the Consumption of Pelleted Dry Food: How Important Is the Quality of the Feed? Toxics 2021, 9, 133 .

AMA Style

Ana Macías-Montes, Manuel Zumbado, Octavio Luzardo, Ángel Rodríguez-Hernández, Andrea Acosta-Dacal, Cristian Rial-Berriel, Luis Boada, Luis Henríquez-Hernández. Nutritional Evaluation and Risk Assessment of the Exposure to Essential and Toxic Elements in Dogs and Cats through the Consumption of Pelleted Dry Food: How Important Is the Quality of the Feed? Toxics. 2021; 9 (6):133.

Chicago/Turabian Style

Ana Macías-Montes; Manuel Zumbado; Octavio Luzardo; Ángel Rodríguez-Hernández; Andrea Acosta-Dacal; Cristian Rial-Berriel; Luis Boada; Luis Henríquez-Hernández. 2021. "Nutritional Evaluation and Risk Assessment of the Exposure to Essential and Toxic Elements in Dogs and Cats through the Consumption of Pelleted Dry Food: How Important Is the Quality of the Feed?" Toxics 9, no. 6: 133.

Journal article
Published: 02 May 2021 in Toxics
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Persistent organic pollutants (POPs) are among the most relevant and dangerous contaminants in soil, from where they can be transferred to crops. Additionally, livestock animals may inadvertently consume relatively high amounts of soil attached to the roots of the vegetables while grazing, leading to indirect exposure to humans. Therefore, periodic monitoring of soils is crucial; thus, simple, robust, and powerful methods are needed. In this study, we have tested and validated an easy QuEChERS-based method for the extraction of 49 POPs (8 PBDEs, 12 OCPs, 11 PAHs, and 18 PCBs) in soils and their analysis by GC-MS/MS. The method was validated in terms of linearity, precision, and accuracy, and a matrix effect study was performed. The limits of detection (LOD) were established between 0.048 and 3.125 ng g−1 and the limits of quantification (LOQ) were between 0.5 and 20 ng g−1, except for naphthalene (50 ng g−1). Then, to verify the applicability of the validated method, we applied it to a series of 81 soil samples from farms dedicated to mixed vegetable cultivation and vineyards in the Canary Islands, both from two modes of production (organic vs. conventional) where residues of OCPs, PCBs, and PAHs were found.

ACS Style

Andrea Acosta-Dacal; Cristian Rial-Berriel; Ricardo Díaz-Díaz; María Bernal-Suárez; Manuel Zumbado; Luis Henríquez-Hernández; Pablo Alonso-González; Eva Parga-Dans; Octavio Luzardo. Validation of a Method Scope Extension for the Analysis of POPs in Soil and Verification in Organic and Conventional Farms of the Canary Islands. Toxics 2021, 9, 101 .

AMA Style

Andrea Acosta-Dacal, Cristian Rial-Berriel, Ricardo Díaz-Díaz, María Bernal-Suárez, Manuel Zumbado, Luis Henríquez-Hernández, Pablo Alonso-González, Eva Parga-Dans, Octavio Luzardo. Validation of a Method Scope Extension for the Analysis of POPs in Soil and Verification in Organic and Conventional Farms of the Canary Islands. Toxics. 2021; 9 (5):101.

Chicago/Turabian Style

Andrea Acosta-Dacal; Cristian Rial-Berriel; Ricardo Díaz-Díaz; María Bernal-Suárez; Manuel Zumbado; Luis Henríquez-Hernández; Pablo Alonso-González; Eva Parga-Dans; Octavio Luzardo. 2021. "Validation of a Method Scope Extension for the Analysis of POPs in Soil and Verification in Organic and Conventional Farms of the Canary Islands." Toxics 9, no. 5: 101.

Journal article
Published: 10 April 2021 in Toxics
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A modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) extraction was validated for the extraction of seven coumarin anticoagulant rodenticides (ARs) and 36 pharmaceutical active compounds (PhACs) residues in soil samples using liquid chromatography tandem mass spectrometry (LC-MS/MS). The aim of this work was to develop a method for the monitoring of these compounds in agricultural lands as well as in forensic applications for the determination of ARs poisoning. As far as is known, this is the first time that a QuEChERS-based method is used for the extraction of ARs in soil, as well as on such a quantity of PhACs. A matrix effect study was carried out on samples of soil devoted to agriculture in the midland area of the Canary Islands (clay loam type). It was in house validated (accuracy, precision, and linearity) at seven spiked levels between 0.5 and 50 ng g−1. The limits of quantification (LOQ) ranged between 0.5 and 50.0 ng g−1 and the limits of detection (LOD) ranged from 0.024 to 6.25 ng g−1. The method was then successfully used for both the determination of the target analytes in the soils from the agricultural plots that had been irrigated with regenerated water, and in the soil collected from underneath wild bird carcasses (which had been the subject of forensic investigation).

ACS Style

Andrea Acosta-Dacal; Cristian Rial-Berriel; Ricardo Díaz-Díaz; María Bernal-Suárez; Manuel Zumbado; Luis Henríquez-Hernández; Octavio Luzardo. An Easy Procedure to Quantify Anticoagulant Rodenticides and Pharmaceutical Active Compounds in Soils. Toxics 2021, 9, 83 .

AMA Style

Andrea Acosta-Dacal, Cristian Rial-Berriel, Ricardo Díaz-Díaz, María Bernal-Suárez, Manuel Zumbado, Luis Henríquez-Hernández, Octavio Luzardo. An Easy Procedure to Quantify Anticoagulant Rodenticides and Pharmaceutical Active Compounds in Soils. Toxics. 2021; 9 (4):83.

Chicago/Turabian Style

Andrea Acosta-Dacal; Cristian Rial-Berriel; Ricardo Díaz-Díaz; María Bernal-Suárez; Manuel Zumbado; Luis Henríquez-Hernández; Octavio Luzardo. 2021. "An Easy Procedure to Quantify Anticoagulant Rodenticides and Pharmaceutical Active Compounds in Soils." Toxics 9, no. 4: 83.

Journal article
Published: 04 December 2020 in Regional Studies in Marine Science
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Due to progressive urban development along the Mexican Caribbean coastline, it is crucial to gauge the impact of anthropogenic contamination of marine ecosystems through biomonitoring procedures. In the current study, we quantified the concentration of 49 inorganic elements in the blood and scute tissues of clinically healthy nesting hawksbill sea turtles (Eretmochelys imbricata). The elements were classified into four groups: Group A: essential mineral elements with toxic potential; Group B: non-essential elements with high toxicity; Group C: toxic non-essential minority elements and Trace Elements (TE); and Group D: rare-earth elements (REE) and other TE. Almost all the samples in both tissues showed perceptible levels of all the quantified elements. The only element identified with a correlation between blood and scute was arsenic (As), which could indicate a fast excretion through this type of keratinized tissue. The bio-accumulation of inorganic elements is a complex process, requiring the simultaneous examination of different tissues to evaluate the exposure. Our study reinforces the usefulness of scute tissue as a non-invasive sampling technique for the evaluation of persistent pollutants in marine turtles.

ACS Style

Maribel Escobedo Mondragón; Octavio P. Luzardo; Manuel Zumbado; Ángel Rodríguez-Hernández; Cristian Rial Berriel; Héctor Vicente Ramírez-Gomez; Carlos González-Rebeles Islas; Roberto F. Aguilar Fisher; J. Rene Rosiles Martínez. Incidence of 49 elements in the blood and scute tissues of nesting hawksbill turtles (Eretmochelys imbricata) in Holbox Island. Regional Studies in Marine Science 2020, 41, 101566 .

AMA Style

Maribel Escobedo Mondragón, Octavio P. Luzardo, Manuel Zumbado, Ángel Rodríguez-Hernández, Cristian Rial Berriel, Héctor Vicente Ramírez-Gomez, Carlos González-Rebeles Islas, Roberto F. Aguilar Fisher, J. Rene Rosiles Martínez. Incidence of 49 elements in the blood and scute tissues of nesting hawksbill turtles (Eretmochelys imbricata) in Holbox Island. Regional Studies in Marine Science. 2020; 41 ():101566.

Chicago/Turabian Style

Maribel Escobedo Mondragón; Octavio P. Luzardo; Manuel Zumbado; Ángel Rodríguez-Hernández; Cristian Rial Berriel; Héctor Vicente Ramírez-Gomez; Carlos González-Rebeles Islas; Roberto F. Aguilar Fisher; J. Rene Rosiles Martínez. 2020. "Incidence of 49 elements in the blood and scute tissues of nesting hawksbill turtles (Eretmochelys imbricata) in Holbox Island." Regional Studies in Marine Science 41, no. : 101566.

Short review
Published: 21 November 2020 in Revista de Senología y Patología Mamaria
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La mamografía con contraste (CEM) es una nueva y prometedora técnica de imagen basada en la neovascularización de los tumores de manera similar a la resonancia magnética de la mama. Los resultados de los estudios clínicos muestran que su rendimiento diagnóstico es significativamente mejor que el de la mamografía digital convencional, y que sus valores de sensibilidad y especificidad la hacen comparable con la resonancia magnética. Sus usos actuales y los propuestos incluyen la evaluación adicional de pacientes sintomáticos o pacientes con exámenes previos anormales, la evaluación de la extensión local de los cánceres de mama recién diagnosticados, el seguimiento de la quimioterapia neoadyuvante y la detección del cáncer de mama en pacientes de alto riesgo. Aunque la técnica se aprobó para uso clínico en 2010, todavía es poco conocida. En esta revisión, presentamos la técnica CEM y sus resultados de rendimiento de diagnóstico comparados con la mamografía convencional y la resonancia magnética de la mama. También presentamos los diferentes escenarios en los que se puede utilizar con éxito, tanto en el diagnóstico de la enfermedad de mama, como en la estadificación local del cáncer de mama, así como su papel potencial en los programas de detección del cáncer de mama. Contrast-enhanced mammography (CEM) is a promising new imaging technique based on neovascularisation of the tumour, similar to magnetic resonance imaging of the breast. The results of clinical studies show that its diagnostic performance is significantly better than that of conventional digital mammography, and that its sensitivity and specificity are comparable to those of magnetic resonance imaging. Its current and proposed uses include further evaluation of symptomatic patients or patients with abnormal results on previous examinations, assessment of the local extension of newly diagnosed breast tumours, follow-up of neoadjuvant chemotherapy and detection of breast cancer in high-risk patients. Although the technique was approved for clinical use in 2010, it is still little known. In this review, we present the technique of CEM and its results in terms of diagnostic performance compared with conventional mammography and breast MRI. We also discuss the various scenarios in which it can be used successfully, both in the diagnosis of breast disease and in the local staging of breast cancer, as well as its potential role in breast cancer screening programmes.

ACS Style

María Del Mar Travieso-Aja; Octavio Pérez-Luzardo. Utilidad clínica de la mamografía con contraste (CEM): una revisión de la literatura. Revista de Senología y Patología Mamaria 2020, 1 .

AMA Style

María Del Mar Travieso-Aja, Octavio Pérez-Luzardo. Utilidad clínica de la mamografía con contraste (CEM): una revisión de la literatura. Revista de Senología y Patología Mamaria. 2020; ():1.

Chicago/Turabian Style

María Del Mar Travieso-Aja; Octavio Pérez-Luzardo. 2020. "Utilidad clínica de la mamografía con contraste (CEM): una revisión de la literatura." Revista de Senología y Patología Mamaria , no. : 1.

Journal article
Published: 20 November 2020 in Environment International
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The major purpose of human biomonitoring is the mapping and assessment of human exposure to chemicals. The European initiative HBM4EU has prioritized seven substance groups and two metals relevant for human exposure: Phthalates and substitutes (1,2-cyclohexane dicarboxylic acid diisononyl ester, DINCH), bisphenols, per- and polyfluoroalkyl substances (PFASs), halogenated and organophosphorous flame retardants (HFRs and OPFRs), polycyclic aromatic hydrocarbons (PAHs), arylamines, cadmium and chromium. As a first step towards comparable European-wide data, the most suitable biomarkers, human matrices and analytical methods for each substance group or metal were selected from the scientific literature, based on a set of selection criteria. The biomarkers included parent compounds of PFASs and HFRs in serum, of bisphenols and arylamines in urine, metabolites of phthalates, DINCH, OPFRs and PAHs in urine as well as metals in blood and urine, with a preference to measure Cr in erythrocytes representing Cr (VI) exposure. High performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was the method of choice for bisphenols, PFASs, the HFR hexabromocyclododecane (HBCDD), phenolic HFRs as well as the metabolites of phthalates, DINCH, OPFRs and PAHs in urine. Gas chromatographic (GC) methods were selected for the remaining compounds, e.g. GC-low resolution MS with electron capture negative ionization (ECNI) for HFRs. Both GC–MS and LC-MS/MS were suitable for arylamines. New developments towards increased applications of GC–MS/MS may offer alternatives to GC–MS or LC-MS/MS approaches, e.g. for bisphenols. The metals were best determined by inductively coupled plasma (ICP)-MS, with the particular challenge of avoiding interferences in the Cd determination in urine. The evaluation process revealed research needs towards higher sensitivity and non-invasive sampling as well as a need for more stringent quality assurance/quality control applications and assessments.

ACS Style

Katrin Vorkamp; Argelia Castaño; Jean-Philippe Antignac; Luis D. Boada; Enrique Cequier; Adrian Covaci; Marta Esteban López; Line S. Haug; Monika Kasper-Sonnenberg; Holger M. Koch; Octavio Pérez Luzardo; Agnese Osīte; Loïc Rambaud; Maria-Teresa Pinorini; Gabriele Sabbioni; Cathrine Thomsen. Biomarkers, matrices and analytical methods targeting human exposure to chemicals selected for a European human biomonitoring initiative. Environment International 2020, 146, 106082 .

AMA Style

Katrin Vorkamp, Argelia Castaño, Jean-Philippe Antignac, Luis D. Boada, Enrique Cequier, Adrian Covaci, Marta Esteban López, Line S. Haug, Monika Kasper-Sonnenberg, Holger M. Koch, Octavio Pérez Luzardo, Agnese Osīte, Loïc Rambaud, Maria-Teresa Pinorini, Gabriele Sabbioni, Cathrine Thomsen. Biomarkers, matrices and analytical methods targeting human exposure to chemicals selected for a European human biomonitoring initiative. Environment International. 2020; 146 ():106082.

Chicago/Turabian Style

Katrin Vorkamp; Argelia Castaño; Jean-Philippe Antignac; Luis D. Boada; Enrique Cequier; Adrian Covaci; Marta Esteban López; Line S. Haug; Monika Kasper-Sonnenberg; Holger M. Koch; Octavio Pérez Luzardo; Agnese Osīte; Loïc Rambaud; Maria-Teresa Pinorini; Gabriele Sabbioni; Cathrine Thomsen. 2020. "Biomarkers, matrices and analytical methods targeting human exposure to chemicals selected for a European human biomonitoring initiative." Environment International 146, no. : 106082.

Short review
Published: 30 October 2020 in Crop Protection
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This paper explores Spanish pesticide policy with a focus on developments during the last decade. Spain is one of the greatest global consumers of conventional pesticides and leader in various related rankings among European Union countries. However, reviews of pesticide policies examining the key plans, facts, strategies and stakeholders are largely lacking. In providing an overview of Spanish responses to the European Directive 2009/128/EC on the Sustainable Use of Pesticides, this article contributes to filling this research gap. Spanish National Action Plans lack measurable quantitative objectives for reduction in the use of conventional pesticides and further implementation of Integrated Pest Management. Spanish National Action Plans also lack strategies for informing citizens about pesticide residues, and efficient means of keeping up to date with the authorisation of new active substances and delivery of pesticide use and sales data, in time and form. Moreover, there are no clear trends in conventional pesticide use reduction and sales, despite a significant reduction in the use of the more toxic active substances. Overall, this paper reveals various important shortcomings and incongruences in Spanish pesticide policy, which deserve further scholarly exploration and should be a matter of concern for public bodies.

ACS Style

Pablo Alonso González; Eva Parga-Dans; Octavio Pérez Luzardo. Big sales, no carrots: Assessment of pesticide policy in Spain. Crop Protection 2020, 141, 105428 .

AMA Style

Pablo Alonso González, Eva Parga-Dans, Octavio Pérez Luzardo. Big sales, no carrots: Assessment of pesticide policy in Spain. Crop Protection. 2020; 141 ():105428.

Chicago/Turabian Style

Pablo Alonso González; Eva Parga-Dans; Octavio Pérez Luzardo. 2020. "Big sales, no carrots: Assessment of pesticide policy in Spain." Crop Protection 141, no. : 105428.

Journal article
Published: 13 October 2020 in Food and Chemical Toxicology
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The nitrate content of the most consumed green leafy vegetables in the European Region of the Canary Islands was determined. The sampling included chard and watercress, which are not regulated but highly consumed in this region. The levels of nitrates in organic vegetables were significantly higher than those of conventional cultivation. However, no seasonal differences were observed, and overall nitrate levels were lower than those reported in other studies. Median nitrate levels in the analyzed vegetables were: lettuce (3 varieties) = 573.7 mg/kg; ready-to-eat salad mixes = 595.0 mg/kg; spinach = 1044.2 mg/kg; arugula = 3144.2 mg/kg; watercress = 450.5 mg/kg; and chard = 1788.4 mg/kg. In general, the nitrate levels of watercress and chard were significantly higher than those of regulated vegetables with similar culinary uses. The average per capita daily intake of nitrates through regulated vegetables was 17.5-32.5% of acceptable daily intake (ADI). On the contrary, the consumption of unregulated vegetables in this archipelago represents a similar, or even higher, percentage of ADI (23.6-44.3%). We, therefore, consider that the establishment of maximum limits of nitrate by the EU regulatory authorities would be appropriate for chard and watercress and similar to those set for spinach.

ACS Style

Verónica Martín León; Octavio P. Luzardo. Evaluation of nitrate contents in regulated and non-regulated leafy vegetables of high consumption in the Canary Islands, Spain: Risk assessment. Food and Chemical Toxicology 2020, 146, 111812 .

AMA Style

Verónica Martín León, Octavio P. Luzardo. Evaluation of nitrate contents in regulated and non-regulated leafy vegetables of high consumption in the Canary Islands, Spain: Risk assessment. Food and Chemical Toxicology. 2020; 146 ():111812.

Chicago/Turabian Style

Verónica Martín León; Octavio P. Luzardo. 2020. "Evaluation of nitrate contents in regulated and non-regulated leafy vegetables of high consumption in the Canary Islands, Spain: Risk assessment." Food and Chemical Toxicology 146, no. : 111812.

Data article
Published: 09 October 2020 in Data in Brief
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The dataset presented in this article supports “Optimization and validation of a method for the simultaneous environmental monitoring of 218 pesticide residues in clay loam soil” [1]. A method based on QuEChERS (Quick, Easy, Cheap, Effective, Rugged & Safe) for the extraction of pesticide and some metabolites residues was developed. The quantification of the chemicals was performed by a combination of two complementary LC-MS/MS and GC-MS/MS analyses. Detailed optimization data of the QuEChERS extraction method is provided, including (1) salt combination, (2) acidification of the solvent (3) the amount of the selected acid (Formic Acid, FA) and (4) moisturization of the soil samples prior to extraction. In addition, all the validation data are presented, including the matrix effect, which was evaluated for each analyte using the recommended procedure.

ACS Style

Andrea Acosta-Dacal; Cristian Rial-Berriel; Ricardo Díaz-Díaz; Mª Del Mar Bernal Suárez; Manuel Zumbado; Luis Alberto Henríquez-Hernández; Octavio P. Luzardo. Supporting dataset on the optimization and validation of a QuEChERS-based method for the determination of 218 pesticide residues in clay loam soil. Data in Brief 2020, 33, 106393 .

AMA Style

Andrea Acosta-Dacal, Cristian Rial-Berriel, Ricardo Díaz-Díaz, Mª Del Mar Bernal Suárez, Manuel Zumbado, Luis Alberto Henríquez-Hernández, Octavio P. Luzardo. Supporting dataset on the optimization and validation of a QuEChERS-based method for the determination of 218 pesticide residues in clay loam soil. Data in Brief. 2020; 33 ():106393.

Chicago/Turabian Style

Andrea Acosta-Dacal; Cristian Rial-Berriel; Ricardo Díaz-Díaz; Mª Del Mar Bernal Suárez; Manuel Zumbado; Luis Alberto Henríquez-Hernández; Octavio P. Luzardo. 2020. "Supporting dataset on the optimization and validation of a QuEChERS-based method for the determination of 218 pesticide residues in clay loam soil." Data in Brief 33, no. : 106393.

Journal article
Published: 02 September 2020 in Toxics
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The role of inorganic elements as risk factors for stroke has been suggested. We designed a case-control study to explore the role of 45 inorganic elements as factors associated with stroke in 92 patients and 83 controls. Nineteen elements were detected in >80% of patients and 21 were detected in >80% of controls. Blood level of lead was significantly higher among patients (11.2 vs. 9.03 ng/mL) while gold and cerium were significantly higher among controls (0.013 vs. 0.007 ng/mL; and 18.0 vs. 15.0 ng/mL). Lead was associated with stroke in univariate and multivariate analysis (OR = 1.65 (95% CI, 1.09–2.50) and OR = 1.91 (95% CI, 1.20–3.04), respectively). Gold and cerium showed an inverse association with stroke in multivariate analysis (OR = 0.81 (95% CI, 0.69–0.95) and OR = 0.50 (95% CI, 0.31–0.78)). Future studies are needed to elucidate the potential sources of exposure and disclose the mechanisms of action.

ACS Style

Florián Medina-Estévez; Manuel Zumbado; Octavio P. Luzardo; Ángel Rodríguez-Hernández; Luis D. Boada; Fernando Fernández-Fuertes; María Elvira Santandreu-Jimenez; Luis Alberto Henríquez-Hernández. Association between Heavy Metals and Rare Earth Elements with Acute Ischemic Stroke: A Case-Control Study Conducted in the Canary Islands (Spain). Toxics 2020, 8, 66 .

AMA Style

Florián Medina-Estévez, Manuel Zumbado, Octavio P. Luzardo, Ángel Rodríguez-Hernández, Luis D. Boada, Fernando Fernández-Fuertes, María Elvira Santandreu-Jimenez, Luis Alberto Henríquez-Hernández. Association between Heavy Metals and Rare Earth Elements with Acute Ischemic Stroke: A Case-Control Study Conducted in the Canary Islands (Spain). Toxics. 2020; 8 (3):66.

Chicago/Turabian Style

Florián Medina-Estévez; Manuel Zumbado; Octavio P. Luzardo; Ángel Rodríguez-Hernández; Luis D. Boada; Fernando Fernández-Fuertes; María Elvira Santandreu-Jimenez; Luis Alberto Henríquez-Hernández. 2020. "Association between Heavy Metals and Rare Earth Elements with Acute Ischemic Stroke: A Case-Control Study Conducted in the Canary Islands (Spain)." Toxics 8, no. 3: 66.

Journal article
Published: 26 August 2020 in Science of The Total Environment
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A modified QuEChERS method was optimized, validated and verified for the extraction of 218 pesticide residues in agricultural soil samples. The 218 analytes are extracted using a single step, without clean-up, with matrix-matched calibration, and two complementary techniques: liquid and gas chromatography tandem triple quad mass spectrometry (LC-MS/MS and GC-MS/MS). Some of the parameters such as salts, acidity of the extraction solvent, sample moisture and some mechanical changes in the procedure were optimized to improve the overall performance for the target compounds and the soil matrix. The method was fully validated on a representative agricultural soil sample of the Canary Islands (clay loam soil) in terms of linearity, accuracy and precision. To avoid matrix effects, matrix-matched calibration curves (R2 ≥ 0.99) were used for all target analytes. 100% of the compounds can be quantified with limits of quantification (LOQ) lower than the limit typically used in soils (50 ng g−1), with 92% of compounds presenting a LOQ that is at least 10 times lower than that normally required. The limits of detection (LOD) ranged between 0.024 and 6.25 ng g−1. The validated method was applied to a series of actual samples of agricultural soil (n = 18). In addition, as a further verification of its potential, the results of the application of the method in the investigation of clay loam soil samples that were obtained from underneath wildlife carcasses in the context of an environmental forensic investigation are also presented.

ACS Style

Andrea Acosta-Dacal; Cristian Rial-Berriel; Ricardo Díaz-Díaz; María Del Mar Bernal-Suárez; Octavio P. Luzardo. Optimization and validation of a QuEChERS-based method for the simultaneous environmental monitoring of 218 pesticide residues in clay loam soil. Science of The Total Environment 2020, 753, 142015 .

AMA Style

Andrea Acosta-Dacal, Cristian Rial-Berriel, Ricardo Díaz-Díaz, María Del Mar Bernal-Suárez, Octavio P. Luzardo. Optimization and validation of a QuEChERS-based method for the simultaneous environmental monitoring of 218 pesticide residues in clay loam soil. Science of The Total Environment. 2020; 753 ():142015.

Chicago/Turabian Style

Andrea Acosta-Dacal; Cristian Rial-Berriel; Ricardo Díaz-Díaz; María Del Mar Bernal-Suárez; Octavio P. Luzardo. 2020. "Optimization and validation of a QuEChERS-based method for the simultaneous environmental monitoring of 218 pesticide residues in clay loam soil." Science of The Total Environment 753, no. : 142015.

Data article
Published: 18 June 2020 in Data in Brief
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The dataset presented in this article supports “Micro QuEChERS-based method for the simultaneous biomonitoring in whole blood of 360 toxicologically relevant pollutants for wildlife” (Rial-Berriel et al., 2020). The supplementary data are: (1) Detailed validation data of the LC-MS/MS and GC-MS/MS methods for the quantification of 360 chemicals covering bias and precision (intra- and inter-day variability) for retention times, linearity, and limits of quantification. (2) Graphical data of the matrix effects on the quantification of all of the analytes. (3) Individual data of the 51 chemicals detected in real whole blood samples from two raptor species: 36 barn owls (Tyto alba) and 112 common kestrels (Falco tinnunculus).

ACS Style

Cristian Rial-Berriel; Andrea Carolina Acosta Dacal; Fernando González; Natalia Pastor-Tiburón; Manuel Zumbado; Octavio P. Luzardo. Supporting dataset on the validation and verification of the analytical method for the biomonitoring of 360 toxicologically relevant pollutants in whole blood. Data in Brief 2020, 31, 105878 .

AMA Style

Cristian Rial-Berriel, Andrea Carolina Acosta Dacal, Fernando González, Natalia Pastor-Tiburón, Manuel Zumbado, Octavio P. Luzardo. Supporting dataset on the validation and verification of the analytical method for the biomonitoring of 360 toxicologically relevant pollutants in whole blood. Data in Brief. 2020; 31 ():105878.

Chicago/Turabian Style

Cristian Rial-Berriel; Andrea Carolina Acosta Dacal; Fernando González; Natalia Pastor-Tiburón; Manuel Zumbado; Octavio P. Luzardo. 2020. "Supporting dataset on the validation and verification of the analytical method for the biomonitoring of 360 toxicologically relevant pollutants in whole blood." Data in Brief 31, no. : 105878.

Journal article
Published: 15 May 2020 in Science of The Total Environment
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This work presents the optimization, validation, and verification of a miniaturized method for the determination of 360 environmental pollutants that are of toxicological concern for wildlife. The method implies a one-step QuEChERS-based extraction of 250 μl whole blood using acidified acetonitrile, followed by two complementary analyses by LC–MS/MS and GC–MS/MS. The optimized conditions allow the simultaneous determination of the major persistent organic pollutants, a wide range of plant protection products, rodenticides, pharmaceuticals, and a suite of metabolites that can be used as biomarkers of exposure. The method is very sensitive, and 95% of the pollutants can be detected at concentrations below 1.5 ng/ml. The method was applied to a series of 148 samples of nocturnal and diurnal wild raptors collected during field ecological studies in 2018 and 2019. Fifty-one different contaminants were found in these samples, with a median value of 7 contaminants per sample. As expected, five of the six contaminants that were detected in >50% of the samples were persistent or semi-persistent organic pollutants. However, it is striking the high frequency of detection of some non-persistent pollutants, such as 2-phenylphenol, benalaxyl, metaflumizone, diphenylamine, brodifacoum or levamisole, indicating the penetration of these chemicals into the food chains. The toxicological significance of all these findings should be studied in depth in future research. However, the results clearly demonstrated that the approach developed provides reliable, simple, and rapid determination of a wide range of pollutants in wildlife and makes it very useful to obtain valuable data in biomonitoring studies with only small amounts of sample.

ACS Style

Cristian Rial-Berriel; Andrea Carolina Acosta Dacal; Manuel Zumbado; Octavio P. Luzardo. Micro QuEChERS-based method for the simultaneous biomonitoring in whole blood of 360 toxicologically relevant pollutants for wildlife. Science of The Total Environment 2020, 736, 139444 .

AMA Style

Cristian Rial-Berriel, Andrea Carolina Acosta Dacal, Manuel Zumbado, Octavio P. Luzardo. Micro QuEChERS-based method for the simultaneous biomonitoring in whole blood of 360 toxicologically relevant pollutants for wildlife. Science of The Total Environment. 2020; 736 ():139444.

Chicago/Turabian Style

Cristian Rial-Berriel; Andrea Carolina Acosta Dacal; Manuel Zumbado; Octavio P. Luzardo. 2020. "Micro QuEChERS-based method for the simultaneous biomonitoring in whole blood of 360 toxicologically relevant pollutants for wildlife." Science of The Total Environment 736, no. : 139444.

Journal article
Published: 05 March 2020 in Environmental Pollution
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Toxic metals have been widely reported in avian tissues due to their well-known accumulation capacity and adverse effects. However, rare earth elements (REE) and other minor elements (ME) are becoming a new threat due to their use in modern technology. Presently, exposure data are limited and no studies have been reported in wildlife. The order Caprimulgiformes is among the most understudied groups of birds lacking blood ecotoxicological data. One major constraint is the small blood sample volume that can be collected to ensure animal welfare, which limits analyses. In order to shed light on these collective issues, we sampled 48 red-necked nightjars (Caprimulgus ruficollis) inhabiting three different scenarios of contaminant exposure (agricultural-urban area, n = 15; mining area, n = 17; and control area, n = 16) in southeastern Spain, and report for the first time concentrations of 50 elements (i.e. trace elements, ATSDR’s list toxic elements, REE and ME) using a recently developed technique able to analyze them by ICP-MS in very small volumes of blood (130 μL). Concentrations of As, Cd, Pb and Mn were significantly higher in individuals captured at the mining area compared to the other sites. Lead levels in the mine site were of particular concern since it was in the range of blood concentrations related to subclinical/clinical effects in other species, and in our study were associated with decreased hematocrit values (up to 44% hematocrit depression at blood concentrations >1000 ng/ml w.w.). Moreover, additive effects related to metal cocktail exposure in the mining area could be expected. Age and gender-related differences in blood concentrations were found for some elements. Even though most REE and ME concentrations were close to the LOQ, some of these emerging contaminants may trigger sublethal effects that, together with the ATSDR’s list toxic elements, need to be carefully evaluated in a future study.

ACS Style

Silvia Espín; Pablo Sánchez-Virosta; José M. Zamora-Marín; Mario León-Ortega; Pedro Jiménez; Manuel Zumbado; Octavio P. Luzardo; Tapio Eeva; Antonio J. García-Fernández. Toxic elements in blood of red-necked nightjars (Caprimulgus ruficollis) inhabiting differently polluted environments. Environmental Pollution 2020, 262, 114334 .

AMA Style

Silvia Espín, Pablo Sánchez-Virosta, José M. Zamora-Marín, Mario León-Ortega, Pedro Jiménez, Manuel Zumbado, Octavio P. Luzardo, Tapio Eeva, Antonio J. García-Fernández. Toxic elements in blood of red-necked nightjars (Caprimulgus ruficollis) inhabiting differently polluted environments. Environmental Pollution. 2020; 262 ():114334.

Chicago/Turabian Style

Silvia Espín; Pablo Sánchez-Virosta; José M. Zamora-Marín; Mario León-Ortega; Pedro Jiménez; Manuel Zumbado; Octavio P. Luzardo; Tapio Eeva; Antonio J. García-Fernández. 2020. "Toxic elements in blood of red-necked nightjars (Caprimulgus ruficollis) inhabiting differently polluted environments." Environmental Pollution 262, no. : 114334.

Journal article
Published: 01 March 2020 in Science of The Total Environment
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Dry feed for dogs and cats sold in Europe are mostly formulated with cereals and cereal by-products, so the contamination of this food with mycotoxins represents a potential risk for these pets. We analyzed a representation of the best-selling feed brands in Spain. The presence of Aflatoxins (B1, B2, G1, and G2), Ochratoxin A, T-2 and HT-2 toxins, Deoxynivalenol, Zearalenone, and Fumonisins (B1 and B2) was quantified, using immunoaffinity columns and LC-MS/MS. In general, mycotoxins were frequently and simultaneously (6-11) detected, with AFB1, FB1, FB2, Deoxynivalenol, and HT-2 detected in 100% of the samples. However, the concentrations of most of them are among the lowest reported so far. Fumonisins were the exception since we report the highest concentrations to date, particularly in cat feed. We practically found no significant differences in the level of mycotoxin contamination in relation to the presumed quality of the feed. We also calculated the daily exposure, and evaluated the acute and chronic health risk posed by these feeds. None of the brands analyzed presented acute risk for any of the mycotoxins. However, the high levels of fumonisins found in some samples could become problematic, if there are hidden forms of them. This is also evident in relation to long-term risk, since in the case of fumonisins the level of exposure exceeds the tolerable daily intake level in 3.5 and 12 times, for dogs and cats respectively. The exposure levels to zearalenone and deoxynivalenol could also be of long-term concern, especially considering the possibility that the continuous exposure to several mycotoxins simultaneously might produce potentiated toxic effects as a result of their synergistic action. Further research on the potential adverse health effects deriving from chronic exposure to low doses of multi-mycotoxin mixtures in pets is needed.

ACS Style

Ana Macías-Montes; Cristian Rial-Berriel; Andrea Carolina Acosta Dacal; Luis Alberto Henríquez-Hernández; Maira Almeida-González; Ángel Rodríguez-Hernández; Manuel Zumbado; Luis D. Boada; Annalisa Zaccaroni; Octavio P. Luzardo. Risk assessment of the exposure to mycotoxins in dogs and cats through the consumption of commercial dry food. Science of The Total Environment 2020, 708, 134592 .

AMA Style

Ana Macías-Montes, Cristian Rial-Berriel, Andrea Carolina Acosta Dacal, Luis Alberto Henríquez-Hernández, Maira Almeida-González, Ángel Rodríguez-Hernández, Manuel Zumbado, Luis D. Boada, Annalisa Zaccaroni, Octavio P. Luzardo. Risk assessment of the exposure to mycotoxins in dogs and cats through the consumption of commercial dry food. Science of The Total Environment. 2020; 708 ():134592.

Chicago/Turabian Style

Ana Macías-Montes; Cristian Rial-Berriel; Andrea Carolina Acosta Dacal; Luis Alberto Henríquez-Hernández; Maira Almeida-González; Ángel Rodríguez-Hernández; Manuel Zumbado; Luis D. Boada; Annalisa Zaccaroni; Octavio P. Luzardo. 2020. "Risk assessment of the exposure to mycotoxins in dogs and cats through the consumption of commercial dry food." Science of The Total Environment 708, no. : 134592.

Chapter
Published: 01 December 2019 in Pets as Sentinels, Forecasters and Promoters of Human Health
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Polycyclic aromatic hydrocarbons (PAHs) are a large group of chemical contaminants, predominantly produced via fossil fuel combustion. They spread easily worldwide, so they are considered as semipersistent pollutants. Many of them are considered as carcinogenic or mutagenic compounds, for example, interacting directly with DNA. Benzo(a)pyrene (BaP) is the most important and well-known PAH. Living beings are exposed everyday through air, water, plastic stuff and smoke and almost by food intake, because they are highly lipophilic. In human risk assessments, monitoring these compounds, or their products, in environment, biological or food samples has attracted enormous interest. Pets commonly share habitat and routine life with humans. In this chapter, the possibility that pets were good sentinels of human exposure to PAHs is studied in detail. Concentrations of parental PAHs and some metabolites between human and pets have been compared. In the case of dogs, their concentrations and profiles of PAHs are very different to those of humans when compared. Dogs had lesser concentration of parental compounds and higher concentration of their metabolites than humans. Similarly, cats present different concentrations and detection frequencies than humans. Therefore, the scarce data available indicate that dogs and cats seem to have different sources of exposition to PAHs than humans. Although more studies are needed, pets do not seem to be good sentinels for human exposure to PAHs.

ACS Style

Cristian Rial-Berriel; Luis Alberto Henríquez-Hernández; Octavio P. Luzardo. Role of Pet Dogs and Cats as Sentinels of Human Exposure to Polycyclic Aromatic Hydrocarbons. Pets as Sentinels, Forecasters and Promoters of Human Health 2019, 65 -81.

AMA Style

Cristian Rial-Berriel, Luis Alberto Henríquez-Hernández, Octavio P. Luzardo. Role of Pet Dogs and Cats as Sentinels of Human Exposure to Polycyclic Aromatic Hydrocarbons. Pets as Sentinels, Forecasters and Promoters of Human Health. 2019; ():65-81.

Chicago/Turabian Style

Cristian Rial-Berriel; Luis Alberto Henríquez-Hernández; Octavio P. Luzardo. 2019. "Role of Pet Dogs and Cats as Sentinels of Human Exposure to Polycyclic Aromatic Hydrocarbons." Pets as Sentinels, Forecasters and Promoters of Human Health , no. : 65-81.

Journal article
Published: 26 November 2019 in Science of The Total Environment
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Heavy metals and other toxic elements are frequently detected in humans. Rare earth elements (REE) have arisen as a novel group of substances considered as emerging pollutants due to its dependence for high tech industry. We designed a study aimed to conduct the biomonitoring a total of 45 inorganic elements in the population of Andalusia (Spain). A total of 419 participants were recruited and their plasma samples analyzed. Concentration of elements, including elements in the ATSDR's priority pollutant list and REE were measured by ICP-MS in the blood plasma of participants. Arsenic, copper, lead, selenium, antimony, strontium, and bismuth were detected in ˃98% of subjects. Median values of arsenic, mercury and lead were 1.49, 1.46, and 5.86 ng/mL, respectively. These concentrations did not exceed reference values published by international agencies. We observed a positive correlation between age and plasma concentrations of arsenic, mercury, antimony and strontium. Sum of elements was lower in the group of subjects younger than 45 years old (P = 0.002). Positive correlations were observed between body mass index (BMI) and plasma concentrations of barium, cerium, osmium, tin, and ytterbium. 7 out of 26 REEs showed a percentage of detection ≥ 90%. Bismuth, yttrium, and cerium were quantified at the highest concentrations (median value = 7.7, 0.19, and 0.16 ng/mL, respectively). We found that plasma levels of 6 REEs were higher among males, and a positive correlation between REEs and age was detected. The present results suggest a potential interaction with the human physiology that deserves additional research. Given the high persistence of these elements in the environment, and the significant technological dependence on them, future studies are needed to elucidate the potential sources of exposure and possible adverse effects on health, especially in the most vulnerable populations.

ACS Style

L.A. Henríquez-Hernández; D. Romero; A. González-Antuña; B. Gonzalez-Alzaga; M. Zumbado; L.D. Boada; A.F. Hernández; I. López-Flores; O.P. Luzardo; M. Lacasaña. Biomonitoring of 45 inorganic elements measured in plasma from Spanish subjects: A cross-sectional study in Andalusian population. Science of The Total Environment 2019, 706, 135750 .

AMA Style

L.A. Henríquez-Hernández, D. Romero, A. González-Antuña, B. Gonzalez-Alzaga, M. Zumbado, L.D. Boada, A.F. Hernández, I. López-Flores, O.P. Luzardo, M. Lacasaña. Biomonitoring of 45 inorganic elements measured in plasma from Spanish subjects: A cross-sectional study in Andalusian population. Science of The Total Environment. 2019; 706 ():135750.

Chicago/Turabian Style

L.A. Henríquez-Hernández; D. Romero; A. González-Antuña; B. Gonzalez-Alzaga; M. Zumbado; L.D. Boada; A.F. Hernández; I. López-Flores; O.P. Luzardo; M. Lacasaña. 2019. "Biomonitoring of 45 inorganic elements measured in plasma from Spanish subjects: A cross-sectional study in Andalusian population." Science of The Total Environment 706, no. : 135750.

Journal article
Published: 21 November 2019 in Radiología (English Edition)
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To determine the usefulness of BI-RADS® MRI for the morphological description and categorization of images obtained with contrast-enhanced digital mammography in comparison with the final diagnosis. We included patients who had palpable breast lesions, those who needed clarification regarding abnormalities identified with another imaging technique, and those who needed a complementary evaluation of heterogeneously dense breast parenchyma. Three radiologists working independently used a template with the BI-RADS® MRI qualitative descriptors to evaluate the breast lesions studied with contrast-enhanced digital mammography. In a second phase, two other experienced radiologists reached a consensus about discrepant interpretations. Readers also classified each lesion (both benign and malignant lesions) on the BI-RADS® scale (1–5). All the results were compared with the real state of disease (determined by the appropriate gold standard for each type of lesion), and the statistical significance was assessed with the chi-square test. A total of 218 benign lesions and 426 malignant lesions were included. The interobserver agreement among the three radiologists was high (Fleiss-Cohen kappa = 0.805; 95% CI: 0.728–0.837). Similarly to what has been reported about breast MRI, on contrast-enhanced digital mammography, malignant lesions with mass effect tended to have an irregular shape with spiculated or ill-defined margins and a pattern of intense and heterogeneous enhancement (p < 0.001). Nevertheless, unlike on breast MRI, ring enhancement was not an independent criterion of malignancy on contrast-enhanced digital mammography. For lesions without a mass effect, the only significant descriptor was the intensity of contrast material uptake (p < 0.05). Applying the BI-RADS® MRI material to contrast-enhanced digital mammography images enabled the correct classification of 85% of lesions in the benign categories (BI-RADS 1 and BI-RADS 2 and 3 lesions) and of 93% of the lesions in the malignant categories (BI-RADS 4–5); these values are similar to those reported for breast MRI. The morphological descriptors used in BI-RADS® MRI can be applied to the morphological analysis of breast lesions studied with contrast-enhanced digital mammography. The partial discrepancies in the interpretation did not influence the final BI-RADS® score, and the score enabled good differentiation between benign and malignant lesions. Se plantea comprobar la utilidad del léxico BI-RADS® de la resonancia magnética de la mama (RMM) para la descripción morfológica y la categorización de las imágenes obtenidas mediante mamografía digital con realce de contraste (CESM) en comparación con el diagnóstico final. Se incluyeron pacientes con lesiones de mama palpables o que necesitaban una aclaración de anormalidades previamente identificadas por otra técnica de diagnóstico por imagen, o una evaluación complementaria de parénquima mamario heterogéneamente denso. Tres radiólogos evaluaron de forma independiente las lesiones de mama estudiadas por CESM utilizando una plantilla que contenía los descriptores morfológicos cualitativos del léxico BI-RADS® de la RMM. En una segunda etapa, otros dos radiólogos experimentados proporcionaron una opinión consensuada sobre casos discrepantes. Los lectores también proporcionaron una clasificación en la escala BI-RADS® de 1 a 5 para cada una de las lesiones, tanto benignas como malignas. Todos los resultados se compararon con el estado real de la enfermedad (estándar de referencia apropiado para el tipo de lesión) y la significación estadística fue evaluada mediante la prueba de χ2. El estudio incluyó 218 lesiones benignas y 426 malignas. Hubo un alto acuerdo interobservador entre los tres radiólogos (valor de kappa de Fleiss-Cohen = 0,805; IC al 95% 0,728–0,837). De forma similar a lo que se ha descrito para la RMM, la evaluación de los descriptores morfológicos de las lesiones que dan efecto de masa mostró que las lesiones malignas tienden a presentar una forma irregular, con bordes espiculados o mal definidos y un patrón de realce intenso y heterogéneo (p < 0,001). Sin embargo, a diferencia de la RMM, el patrón de realce en anillo no se puede describir como un criterio independiente de malignidad con esta técnica. Con respecto a las lesiones que no dan efecto de masa, el único descriptor significativo fue la intensidad de la captación del medio de contraste (p < 0,05). La aplicación global del léxico BI-RADS® de la RMM para CESM permitió la clasificación adecuada del 85% de las categorías benignas (BI-RADS 1 y lesiones BI-RADS 2 y 3) y el 93% de las lesiones malignas (BI-RADS 4–5), que son valores similares a los descritos para RMM. Los descriptores morfológicos del léxico BI-RADS® de la RMM se pueden aplicar al análisis morfológico de lesiones de mama estudiadas por CESM. Las discrepancias parciales en la interpretación no influyeron en la puntuación final de BI-RADS®, lo que permite una buena diferenciación de las lesiones benignas y malignas.

ACS Style

M.M. Travieso-Aja; D. Maldonado-Saluzzi; P. Naranjo-Santana; C. Fernández-Ruiz; W. Severino-Rondón; M. Rodríguez Rodríguez; O.P. Luzardo. Evaluation of the applicability of BI-RADS® MRI for the interpretation of contrast-enhanced digital mammography. Radiología (English Edition) 2019, 61, 477 -488.

AMA Style

M.M. Travieso-Aja, D. Maldonado-Saluzzi, P. Naranjo-Santana, C. Fernández-Ruiz, W. Severino-Rondón, M. Rodríguez Rodríguez, O.P. Luzardo. Evaluation of the applicability of BI-RADS® MRI for the interpretation of contrast-enhanced digital mammography. Radiología (English Edition). 2019; 61 (6):477-488.

Chicago/Turabian Style

M.M. Travieso-Aja; D. Maldonado-Saluzzi; P. Naranjo-Santana; C. Fernández-Ruiz; W. Severino-Rondón; M. Rodríguez Rodríguez; O.P. Luzardo. 2019. "Evaluation of the applicability of BI-RADS® MRI for the interpretation of contrast-enhanced digital mammography." Radiología (English Edition) 61, no. 6: 477-488.

Articles
Published: 01 November 2019 in International Journal of Environmental Health Research
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Inorganic elements have been associated with brain tumours for long. The blood concentration of 47 elements was assessed by ICP-MS in 26 brain tumour patients and 21 healthy subjects from Bucharest (Romania). All 47 elements were detected in the brain tumour tissue, and 22 were detected in > 80% of samples; this implies that these elements can cross the blood-brain barrier. Median blood levels of cadmium, lead, and nickel were higher than the reference values (1.14, 53.3, and 2.53 ng/mL). Gadolinium and tantalum showed significantly higher concentrations among cases. We observed considerable differences and different profiles of the presence of inorganic elements between the tumour and non-tumour brain tissue and between tissue from the primary tumour and tissue from brain metastasis. Our data suggest that similar to heavy metals, other elements – commonly used in high tech devices and rare earth elements – can also influence brain tumour.

ACS Style

Laura Gaman; Mugurel Petrinel Radoi; Corina Elena Delia; Octavio P. Luzardo; Manuel Zumbado; Ángel Rodríguez-Hernández; Irina Stoian; Marilena Gilca; Luis D. Boada; Luis Alberto Henríquez-Hernández. Concentration of heavy metals and rare earth elements in patients with brain tumours: Analysis in tumour tissue, non-tumour tissue, and blood. International Journal of Environmental Health Research 2019, 1 -14.

AMA Style

Laura Gaman, Mugurel Petrinel Radoi, Corina Elena Delia, Octavio P. Luzardo, Manuel Zumbado, Ángel Rodríguez-Hernández, Irina Stoian, Marilena Gilca, Luis D. Boada, Luis Alberto Henríquez-Hernández. Concentration of heavy metals and rare earth elements in patients with brain tumours: Analysis in tumour tissue, non-tumour tissue, and blood. International Journal of Environmental Health Research. 2019; ():1-14.

Chicago/Turabian Style

Laura Gaman; Mugurel Petrinel Radoi; Corina Elena Delia; Octavio P. Luzardo; Manuel Zumbado; Ángel Rodríguez-Hernández; Irina Stoian; Marilena Gilca; Luis D. Boada; Luis Alberto Henríquez-Hernández. 2019. "Concentration of heavy metals and rare earth elements in patients with brain tumours: Analysis in tumour tissue, non-tumour tissue, and blood." International Journal of Environmental Health Research , no. : 1-14.