Surgery for brain cancer is a major problem in neurosurgery. The diffuse infiltration into the surrounding normal brain by these tumors makes their accurate identification by the naked eye difficult. Since surgery is the common treatment for brain cancer, an accurate radical resection of the tumor leads to improved survival rates for patients. However, the identification of the tumor boundaries during surgery is challenging. Hyperspectral imaging is a non-contact, non-ionizing and non-invasive technique suitable for medical diagnosis. This study presents the development of a novel classification method taking into account the spatial and spectral characteristics of the hyperspectral images to help neurosurgeons to accurately determine the tumor boundaries in surgical-time during the resection, avoiding excessive excision of normal tissue or unintentionally leaving residual tumor. The algorithm proposed in this study to approach an efficient solution consists of a hybrid framework that combines both supervised and unsupervised machine learning methods. Firstly, a supervised pixel-wise classification using a Support Vector Machine classifier is performed. The generated classification map is spatially homogenized using a one-band representation of the HS cube, employing the Fixed Reference t-Stochastic Neighbors Embedding dimensional reduction algorithm, and performing a K-Nearest Neighbors filtering. The information generated by the supervised stage is combined with a segmentation map obtained via unsupervised clustering employing a Hierarchical K-Means algorithm. The fusion is performed using a majority voting approach that associates each cluster with a certain class. To evaluate the proposed approach, five hyperspectral images of surface of the brain affected by glioblastoma tumor in vivo from five different patients have been used. The final classification maps obtained have been analyzed and validated by specialists. These preliminary results are promising, obtaining an accurate delineation of the tumor area.

Hyperspectral imaging (HSI) allows for the acquisition of large numbers of spectral bands throughout the electromagnetic spectrum (within and beyond the visual range) with respect to the surface of scenes captured by sensors. Using this information and a set of complex classification algorithms, it is possible to determine which material or substance is located in each pixel. The work presented in this paper aims to exploit the characteristics of HSI to develop a demonstrator capable of delineating tumor tissue from brain tissue during neurosurgical operations. Improved delineation of tumor boundaries is expected to improve the results of surgery. The developed demonstrator is composed of two hyperspectral cameras covering a spectral range of 400–1700 nm. Furthermore, a hardware accelerator connected to a control unit is used to speed up the hyperspectral brain cancer detection algorithm to achieve processing during the time of surgery. A labeled dataset comprised of more than 300,000 spectral signatures is used as the training dataset for the supervised stage of the classification algorithm. In this preliminary study, thematic maps obtained from a validation database of seven hyperspectral images of in vivo brain tissue captured and processed during neurosurgical operations demonstrate that the system is able to discriminate between normal and tumor tissue in the brain. The results can be provided during the surgical procedure (~1 min), making it a practical system for neurosurgeons to use in the near future to improve excision and potentially improve patient outcomes.

During the last decade, Deep Neural Networks (DNN) have progressively been integrated on all types of platforms, from data centers to embedded systems including low-power processors and, recently, FPGAs. Neural Networks (NN) are expected to become ubiquitous in IoT systems by transforming all sorts of real-world applications, including applications in the safety-critical and security-sensitive domains. However, the underlying hardware security vulnerabilities of embedded NN implementations remain unaddressed. In particular, embedded DNN implementations are vulnerable to Side-Channel Analysis (SCA) attacks, which are especially important in the IoT and edge computing contexts where an attacker can usually gain physical access to the targeted device. A research field has therefore emerged and is rapidly growing in terms of the use of SCA including timing, electromagnetic attacks and power attacks to target NN embedded implementations. Since 2018, research papers have shown that SCA enables an attacker to recover inference models architectures and parameters, to expose industrial IP and endangers data confidentiality and privacy. Without a complete review of this emerging field in the literature so far, this paper surveys state-of-the-art physical SCA attacks relative to the implementation of embedded DNNs on micro-controllers and FPGAs in order to provide a thorough analysis on the current landscape. It provides a taxonomy and a detailed classification of current attacks. It first discusses mitigation techniques and then provides insights for future research leads.

The use of hyperspectral imaging (HSI) in the medical field is an emerging approach to assist physicians in diagnostic or surgical guidance tasks. However, HSI data processing involves very high computational requirements due to the huge amount of information captured by the sensors. One of the stages with higher computational load is the K-Nearest Neighbors (KNN) filtering algorithm. The main goal of this study is to optimize and parallelize the KNN algorithm by exploiting the GPU technology to obtain real-time processing during brain cancer surgical procedures. This parallel version of the KNN performs the neighbor filtering of a classification map (obtained from a supervised classifier), evaluating the different classes simultaneously. The undertaken optimizations and the computational capabilities of the GPU device throw a speedup up to 66.18× when compared to a sequential implementation.

This paper presents an evolvable hardware system, fully contained in an FPGA, which is capable of autonomously generating digital processing circuits, implemented on an array of processing elements (PEs). Candidate circuits are generated by an embedded evolutionary algorithm and implemented by means of dynamic partial reconfiguration, enabling evaluation in the final hardware. The PE array follows a systolic approach, and PEs do not contain extra logic such as path multiplexers or unused logic, so array performance is high. Hardware evaluation in the target device and the fast reconfiguration engine used yield smaller reconfiguration than evaluation times. This means that the complete evaluation cycle is faster than software-based approaches and previous evolvable digital systems. The selected application is digital image filtering and edge detection. The evolved filters yield better quality than classic linear and nonlinear filters using mean absolute error as standard comparison metric. Results do not only show better circuit adaptation to different noise types and intensities, but also a nondegrading filtering behavior. This means they may be run iteratively to enhance filtering quality. These properties are even kept for high noise levels (40 percent). The system as a whole is a step toward fully autonomous, adaptive systems.