Under the action of cement hydration heat, the construction environment, thermal insulation measures, and pipe cooling systems, a mass concrete pile cap is subject to a complex internal temperature field, which makes it difficult to control its internal surface temperature difference (T_ISTD), the internal adiabatic temperature rise (T_IATR), and the surface temperature (T_ST). In this study, a mass concrete pile cap of a very large bridge (the length, width, and height were 26.40 m, 20.90 m, and 5.00 m, respectively, and the central-pier pile cap was constructed with C40 concrete) was taken as the research object. The control factors affecting the temperature field of the pile cap were determined by comparing the field temperature measurements with the values calculated with finite element software simulation analysis. By using Midas Civil (2022 v1.2) and Midas FEA (NX 2022) finite element software, these factors (the concrete mold temperature, the concrete surface convection coefficient, the ambient temperature, the pipe cooling system parameters, etc.) were numerically analyzed, and their influence laws and degrees were determined.