Low-melting bioabsorbable polymers, such as poly(caprolactone-co-lactide) (PCLA), hold significant promise for biomedical applications. However, achieving high-precision micro- and nanotopographical functionalization remains a formidable challenge due to the material’s susceptibility to thermal deformation during conventional thermal molding processes. In this study, functional microstructured PCLA coatings were engineered via low-temperature nanoimprint lithography utilizing a TiO₂–SiO₂ gas-permeable mold. These molds were synthesized via a sol–gel method utilizing titanium dioxide and silicon precursors. The gas-permeable nature of the mold facilitated the efficient evacuation of trapped air and volatiles during the imprinting process, enabling the high-fidelity replication of microstructures (1.3 μm height, 3 μm pitch) and nanostructured PCLA coatings featuring linewidths as narrow as 600 nm. The resultant microstructured PCLA coatings demonstrated modulated surface wettability, evidenced by an increase in water contact angles from 70.1° to 91.4°, and exhibited enhanced FD4 elution kinetics. These results confirm morphology-driven functionalities, specifically hydrophobicity and controlled release capabilities. Collectively, these findings underscore the efficacy of this microfabrication approach for polycaprolactone-based materials and highlight its potential to catalyze the development of high-value-added biomaterials for advanced medical and life science applications. This study establishes a foundational framework for the practical deployment of next-generation bioabsorbable materials and is anticipated to drive innovation in precision medical manufacturing.

The rapid advancement of medical science in China has made teaching pharmacology increasingly challenging. Traditional teaching methods, mainly relying on didactic lectures and experimental sessions, are no longer sufficient to meet the diverse learning needs of modern students or to keep pace with newly developed drugs. Educators are required to continuously update their knowledge and adopt innovative teaching strategies such as problem-based learning (PBL), team-based learning (TBL), and flipped classrooms (FC). These approaches have been shown to improve student engagement, attendance, academic performance, and overall satisfaction. However, language barriers remain a major challenge, as pharmacological terminology is largely derived from Greek and Latin. To address this issue, strategies such as breaking complex terms into smaller components and implementing flipped classroom models are recommended. Pharmacology plays a vital role in medical education by linking drug mechanisms with clinical application. This paper highlights innovative teaching methods, technology-based tools, collaborative learning, and bilingual support to enhance pharmacology education in China.