Titanium alloys are crucial in precision manufacturing due to their exceptional properties, but traditional machining methods lead to tool wear, deformation, and high costs. Conventional cooling fluids reduce heat but cause environmental issues, necessitating more sustainable solutions. Cryogenic Minimum Quantity Lubrication (CMQL) technology, using liquid nitrogen or carbon dioxide with minimal amounts of cutting fluid, offers an eco-friendly alternative that reduces machining temperatures and friction. This study tested the TC6 titanium alloy under conventional and CMQL conditions, focusing on tool wear, surface quality, and machining efficiency. Results showed that CMQL significantly decreased tool wear and surface roughness, with a 42% reduction in surface roughness during drilling and a 20–30% efficiency increase. The findings highlight CMQL’s potential to improve machining quality and efficiency while promoting environmentally friendly practices in the industry.