A automedicação e o uso irracional de medicamentos são práticas comuns entre a população brasileira, culminando em problemas secundários ocasionados por essa prática. As classes farmacológicas que estão envolvidas na automedicação são os denominados fármacos de venda livre de prescrição (MIPs), e vários fatores contribuem para a indução da prática de se automedicar, como fatores financeiros, culturais e sociais. Portanto, o profissional farmacêutico assume importante papel como orientador e agente sanitário, contribuindo para o uso racional de medicamentos e amenizando problemas relacionados ao uso inadequado de fármacos, beneficiando toda a população, que, de maneira geral, possui fácil acesso a esses profissionais.

Introduction: We sought to evaluate the effects of a 12-week pulmonary rehabilitation (PR) program on lung function, mechanics, as well as pulmonary and systemic inflammation in a cohort of 33 individuals with moderate to severe post-COVID-19. Material and Methods: The pulmonary rehabilitation (PR) program employed a combination of aerobic and resistance exercises. Thirty minutes of treadmill training at 75% of the maximum heart rate, combined with 30 min resistance training consisting of 75% of one maximum repetition, three times a week throughout 12 weeks. Results: PR improved the lung function, FVC (p < 0.02), FEV1 (p < 0.02), FEV1/FVC (p < 0.01), MEF25% (p < 0.006), MEF50% (p < 0.03), and MEF75% (p < 0.02). PR also positively influenced lung mechanics, reducing respiratory impedance (Z5Hz, p < 0.03), respiratory reactance (X5Hz, p < 0.01), resistance of the entire respiratory system (R5Hz, p < 0.03), central airway resistance (RCentral, p < 0.03), and peripheral airway resistance (RPeripheral, p < 0.02). Moreover, muscle strength gains were evident, with significant improvements observed in hand grip strength for both the right (p < 0.02) and left (p < 0.01) hands, as well as maximal inspiratory (p < 0.02) and expiratory (p < 0.03) pressures. Additionally, PR exhibited anti-inflammatory effects by reducing the pro-inflammatory cytokines IL-1β (p < 0.0001) and IL-6 (p < 0.0001) and increasing the anti-inflammatory IL-1RA (p < 0.0004) and IL-10 (p < 0.003) and anti-viral IFN-γ (p < 0.0002) and IFN-β (p < 0.008) cytokines in breath condensate and serum samples. Conclusions: Collectively, these findings highlight the effectiveness of PR in ameliorating COVID-19 sequel across respiratory system, skeletal muscle, and immune responses. This highlights its promising potential as a therapeutic intervention for individuals recovering from COVID-19.

Introduction: Ergospirometry is a noninvasive procedure used to assess physical performance or the capacity of an individual, through an analysis of expired gases and respiratory variables. This procedure is crucially important in sports, and makes a significant contribution to the measurement of cardiorespiratory fitness indices, such as maximal oxygen consumption (VO2 max) and the anaerobic threshold (AT). Objective: To assess aerobic capacity and potency in professional and junior soccer players, handball athletes, and women soccer players. Methods: Forty-eight athletes participated voluntarily and were divided into 4 groups. The first group consisted of 12 youth soccer players in the under-20 category, the second group was made up of 12 professional soccer players, the third group was made up of female soccer players, and the fourth group consisted of handball players. Results: We analyzed values such as peak VO2, average speed and heart rate at the anaerobic threshold as well as pulmonary ventilation. We found that the values were always greater for the group formed by professional soccer players, with the exception of mean maximum O2 consumption, in which the difference between this group and that of soccer players in the junior category was not significant. In other physical valences, there was a degree of similarity between the other groups, with special emphasis on pulmonary ventilation, which was significantly lower in the group of female soccer players. Conclusion: The particularities of each sport, such as pitch dimensions, duration, and tactical system, together with the morphology and sex of the athletes, directly influence peak VO2, AT and VE values in athletes who play different sports. Level of Evidence III; Development of diagnostic criteria in consecutive patients (with gold reference standard applied).

Avaliação do descarte adequado de medicamentos vencidos e não utilizados no município de Jacareí-SP / Analysis of the appropriate disposal of expired and non used medications in Jacareí-SP

Caracterização do perfil das intoxicações medicamentosas na população de Taubaté, São Paulo, no período de 2014 a 2018 / Characterization of the profile of drug intoxications in the population of Taubaté, São Paulo, from 2014 to 2018

A automedicação que muitas vezes é vista como uma forma de alívio rápido para alguns sintomas pode ser mais prejudicial para a saúde do que se pode imaginar. Trata-se de uma prática que resulta na ingestão de medicamentos sem o aconselhamento e acompanhamento de um profissional qualificado da saúde, ou seja, é a ingestão de medicamentos por conta e risco do indivíduo. Nesse sentido objetivou-se determinar a quantidade de universitários do curso de biomedicina em uma universidade no município de São José dos Campos, que realizam a automedicação, e os principais fatores indutores dessa prática. O estudo foi realizado por meio de questionário com múltiplas escolhas, abordando o conhecimento e as consequências da automedicação. Foram entrevistados 50 universitários voluntários, de ambos os sexos, e após a coleta de dados, as informações obtidas foram processadas estatisticamente. Observou-se que 100% dos entrevistados afirmaram que já praticaram pelo menos uma vez a automedicação e 96% alegaram que compraram o medicamento com facilidade. Foi observado também que a classe dos analgésicos foi a mais relatada. Com isso pode-se perceber que os estudantes da área da saúde especificamente alunos de biomedicina mesmo com conhecimento sobre o assunto e sobre os riscos, realizam essa prática com frequência. Behavior of College of biomedicine course at the realization of self-medication practice Abstract: Self-medication is often seen as a form of quick relief for some symptoms may be more harmful to health than you can imagine. It is a practice that results in drug intake without the advice and assistance of a qualified health professional. In this sense it was aimed to determine the amount of Biomedicine course students at a university in São José dos Campos, who perform self-medication, and the main factors that induce this practice. The study was conducted through a questionnaire with multiple choice, addressing the knowledge and self-medication consequences. They interviewed 50 college volunteers of both sexes, and after data collection, information obtained were processed statistically. It was observed that 100 % of respondents said they have already practiced at least once to self-medication, and 96 % claimed they bought the product easily. It was also observed that the class of analgesics was further reported. It can be seen that the students in the health area specifically biomedicine students even with knowledge of the subject and the risks, carry out this practice frequently.